Streptozotocin‐Induced Oxidative Stress in Rats: The Protective Role of Olive Leaf Extract

2020 ◽  
Author(s):  
Ahmet Gökhan Ağgül ◽  
Fatma Gür ◽  
Mine Gülaboğlu
Keyword(s):  
Oxidative Stress ◽  
Leaf Extract ◽  
Protective Role ◽  
Olive Leaf ◽  
Olive Leaf Extract

Olive leaf extract decreases age-induced oxidative stress in major organs of aged rats

2014 ◽  
Vol 14 (4) ◽  
pp. 996-1002 ◽  
Author(s):  
Jale Çoban ◽  
Serdar Öztezcan ◽  
Semra Doğru-Abbasoğlu ◽  
Ilknur Bingül ◽  
Kübra Yeşil-Mizrak ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Leaf Extract ◽  
Aged Rats ◽  
Olive Leaf ◽  
Olive Leaf Extract

Effect of Tunisian Olive Leaf Extract on oxidative stress and lung fibrosis in rats

2020 ◽  
Author(s):  
Sana Bahri ◽  
Raed Abdennabi ◽  
Afef Nahdi ◽  
Ridha Ben Ali ◽  
Mona Mlika ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Lung Fibrosis ◽  
Leaf Extract ◽  
Olive Leaf ◽  
Olive Leaf Extract

Antioxidant and anti-inflammatory effect of olive leaf extract treatment in diabetic rat brain

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Mehmet Berköz ◽  
Tahir Kahraman ◽  
Zwain Nozad Shamsulddin ◽  
Mirosław Krośniak
Keyword(s):  
Oxidative Stress ◽  
Fatty Acid Composition ◽  
Fatty Acid ◽  
Proinflammatory Cytokines ◽  
Leaf Extract ◽  
Glycated Hemoglobin ◽  
Density Lipoprotein ◽  
Diabetic Rats ◽  
Olive Leaf ◽  
Olive Leaf Extract

Abstract Objectives Olive (Olea europaea L.) plays a promising role in pharmaceutical, nutraceutical, and cosmetic production. On the other hand, olive leaf is widely used in folk medicine due to its antihyperglycemic activity. For this aim, possible effects of olive leaf extract (OLE) in the brain tissue of streptozotocin-induced diabetic rats were investigated. Methods A total of 28 male rats were divided into four equal groups as control, diabetic (single dose of 45 mg/kg streptozotocin, i.p.), OLE (500 mg/kg/day), and diabetic + OLE groups. The study was terminated 21 days after the diabetes model was formed. At the end of the study, all the animals were sacrificed and blood and brain tissues were isolated. Relative brain weights, complete blood count, blood glycated hemoglobin, serum glucose, total protein, total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, triglycerides, insulin, gonadal hormone levels, production and messenger ribonucleic acid (mRNA) levels of proinflammatory cytokines and mediators, total thiol, total oxidative stress, and total antioxidant status levels and fatty acid composition in brain tissue were measured in all study groups. Results In diabetic rats, relative brain weight and serum insulin level decreased, glycated hemoglobin, oxidative stress, production and mRNA level of proinflammatory cytokines and mediators increased, hyperglycemia, hypercholesterolemia and hypertriglyceridemia, degraded fatty acid composition, anemia, leukopenia, and thrombocytopenia occurred. After OLE treatment, a remarkable improvement in most of these parameters, except gonadal hormones, has been observed in diabetic rats. Conclusions This study suggests that olive leaf can be a precious neuroprotective agent in diabetes.

scholarly journals Protective Role of Glutathione in the Hippocampus after Brain Ischemia

2021 ◽  
Vol 22 (15) ◽  
pp. 7765
Author(s):  
Youichirou Higashi ◽  
Takaaki Aratake ◽  
Takahiro Shimizu ◽  
Shogo Shimizu ◽  
Motoaki Saito
Keyword(s):  
Oxidative Stress ◽  
Neuronal Death ◽  
Excitatory Amino Acid ◽  
Ischemia Reperfusion ◽  
Thiol Group ◽  
Protective Role ◽  
Key Factor ◽  
Rate Limiting ◽  
Cysteine Uptake

Stroke is a major cause of death worldwide, leading to serious disability. Post-ischemic injury, especially in the cerebral ischemia-prone hippocampus, is a serious problem, as it contributes to vascular dementia. Many studies have shown that in the hippocampus, ischemia/reperfusion induces neuronal death through oxidative stress and neuronal zinc (Zn2+) dyshomeostasis. Glutathione (GSH) plays an important role in protecting neurons against oxidative stress as a major intracellular antioxidant. In addition, the thiol group of GSH can function as a principal Zn2+ chelator for the maintenance of Zn2+ homeostasis in neurons. These lines of evidence suggest that neuronal GSH levels could be a key factor in post-stroke neuronal survival. In neurons, excitatory amino acid carrier 1 (EAAC1) is involved in the influx of cysteine, and intracellular cysteine is the rate-limiting substrate for the synthesis of GSH. Recently, several studies have indicated that cysteine uptake through EAAC1 suppresses ischemia-induced neuronal death via the promotion of hippocampal GSH synthesis in ischemic animal models. In this article, we aimed to review and describe the role of GSH in hippocampal neuroprotection after ischemia/reperfusion, focusing on EAAC1.

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