Olive leaf extract attenuates adriamycin‐induced focal segmental glomerulosclerosis in spontaneously hypertensive rats via suppression of oxidative stress, hyperlipidemia, and fibrosis

2020 ◽  
Author(s):  
Danijela Karanovic ◽  
Nevena Mihailovic‐Stanojevic ◽  
Zoran Miloradovic ◽  
Milan Ivanov ◽  
Una‐Jovana Vajic ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Focal Segmental Glomerulosclerosis ◽  
Spontaneously Hypertensive Rats ◽  
Leaf Extract ◽  
Olive Leaf ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive ◽  
Olive Leaf Extract ◽  
Segmental Glomerulosclerosis

Antihypertensive effects of oleuropein-enriched olive leaf extract in spontaneously hypertensive rats

2016 ◽  
Vol 7 (1) ◽  
pp. 584-593 ◽  
Author(s):  
M. Romero ◽  
M. Toral ◽  
M. Gómez-Guzmán ◽  
R. Jiménez ◽  
P. Galindo ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Endothelial Function ◽  
Spontaneously Hypertensive Rats ◽  
Leaf Extract ◽  
Olive Leaf ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive ◽  
Olive Leaf Extract ◽  
Inflammatory Status

The effects of chronic consumption of oleuropein-enriched (15% w/w) olive leaf extract (OLE) on blood pressure, endothelial function, and vascular oxidative and inflammatory status in spontaneously hypertensive rats (SHR) were evaluated.

scholarly journals Effects of high dose olive leaf extract on haemodynamic and oxidative stress parameters in normotensive and spontaneously hypertensive rats

2014 ◽  
Vol 79 (9) ◽  
pp. 1085-1097 ◽  
Author(s):  
Dragana Dekanski ◽  
Nevena Mihailovic-Stanojevic ◽  
Grujic Milanovic ◽  
Djurdjica Jovovic ◽  
Zoran Miloradovic
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Glutathione Reductase ◽  
Spontaneously Hypertensive Rats ◽  
Leaf Extract ◽  
High Dose ◽  
Olive Leaf ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive ◽  
Olive Leaf Extract

Antihypertensive activity of natural antioxidant, olive leaf extract (OLE) is known, but its influence on cardiovascular system when administered in a high dose has not been investigated yet. Our aim was to determine the acute effects of excessive intake of standardized OLE on blood pressure, heart rate and oxidative status in both spontaneously hypertensive rats and normotensive Wistar rats. Systolic arterial pressure and heart rate were measured using a tail-cuff, pneumatic pulse detector, before, 60 and 120 minutes after intragastric OLE administration. Activities of catalase, glutathione peroxidase, superoxide dismutase (SOD) and glutathione reductase in erythrocytes, as well as lipid peroxidation in plasma (pTBARS) were measured at the same time points, spectrophotometrically. High-dose OLE did not influence blood pressure, heart rate and pTBARS in normotensive rats, while SOD, catalase, and glutathione reductase activities significantly increased. The same dose significantly decreased blood pressure in hypertensive rats, but increased pTBARS and SOD activity. Excessive oral intake of OLE induced moderate hypotensive effects in spontaneously hypertensive rats only, suggesting absence of harmful haemodynamic effects after oral overdose in both rats strain. However, its prooxidative role when given in high dose in hypertensive organism should not be neglected.

Urtica dioica L. leaf extract modulates blood pressure and oxidative stress in spontaneously hypertensive rats

Phytomedicine ◽  
2018 ◽  
Vol 46 ◽  
pp. 39-45 ◽  
Author(s):  
Una-Jovana Vajic ◽  
Jelica Grujic-Milanovic ◽  
Zoran Miloradovic ◽  
Djurdjica Jovovic ◽  
Milan Ivanov ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Blood Pressure ◽  
Spontaneously Hypertensive Rats ◽  
Leaf Extract ◽  
Urtica Dioica ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive ◽  
And Oxidative Stress

In Vivo Evidence for Microvascular Oxidative Stress in Spontaneously Hypertensive Rats

Hypertension ◽  
1995 ◽  
Vol 25 (5) ◽  
pp. 1083-1089 ◽  
Author(s):  
Hidekazu Suzuki ◽  
Allen Swei ◽  
Benjamin W. Zweifach ◽  
Geert W. Schmid-Schönbein
Keyword(s):  
Oxidative Stress ◽  
Spontaneously Hypertensive Rats ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive

scholarly journals Immunohistochemical Analysis of 4-HNE, NGAL, and HO-1 Tissue Expression after Apocynin Treatment and HBO Preconditioning in Postischemic Acute Kidney Injury Induced in Spontaneously Hypertensive Rats

Antioxidants ◽  
2021 ◽  
Vol 10 (8) ◽  
pp. 1163
Author(s):  
Sanjin Kovacevic ◽  
Milan Ivanov ◽  
Maja Zivotic ◽  
Predrag Brkic ◽  
Zoran Miloradovic ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Acute Kidney Injury ◽  
Spontaneously Hypertensive Rats ◽  
Kidney Injury ◽  
Immunohistochemical Analysis ◽  
Tissue Expression ◽  
Pure Oxygen ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive ◽  
Renal Expression

Oxidative stress has been considered as a central aggravating factor in the development of postischemic acute kidney injury (AKI). The aim of this study was to perform the immunohistochemical analysis of 4-hydroxynonenal (4-HNE), neutrophil gelatinase-associated lipocalin (NGAL), and heme oxygenase-1 (HO-1) tissue expression after apocynin (APO) treatment and hyperbaric oxygenation (HBO) preconditioning, applied as single or combined protocol, in postischemic acute kidney injury induced in spontaneously hypertensive rats (SHR). Twenty-four hours before AKI induction, HBO preconditioning was carried out by exposing to pure oxygen (2.026 bar) twice a day, for 60 min in two consecutive days. Acute kidney injury was induced by removal of the right kidney while the left renal artery was occluded for 45 min by atraumatic clamp. Apocynin was applied in a dose of 40 mg/kg body weight, intravenously, 5 min before reperfusion. We showed increased 4-HNE renal expression in postischemic AKI compared to Sham-operated (SHAM) group. Apocynin treatment, with or without HBO preconditioning, improved creatinine and phosphate clearances, in postischemic AKI. This improvement in renal function was accompanied with decreased 4-HNE, while HO-1 kidney expression restored close to the control group level. NGAL renal expression was also decreased after apocynin treatment, and HBO preconditioning, with or without APO treatment. Considering our results, we can say that 4-HNE tissue expression can be used as a marker of oxidative stress in postischemic AKI. On the other hand, apocynin treatment and HBO preconditioning reduced oxidative damage, and this protective effect might be expected even in experimental hypertensive condition.

scholarly journals Diabetes mellitus activates fetal gene program and intensifies cardiac remodeling and oxidative stress in aged spontaneously hypertensive rats

2013 ◽  
Vol 12 (1) ◽  
pp. 152 ◽  
Author(s):  
Camila Rosa ◽  
Natasha Xavier ◽  
Dijon Henrique Campos ◽  
Ana Angélica Fernandes ◽  
Marcelo Diarcadia Cezar ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Diabetes Mellitus ◽  
Cardiac Remodeling ◽  
Spontaneously Hypertensive Rats ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive ◽  
And Oxidative Stress
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