scholarly journals Neoplastic cannibalism and a suggestion for changes in terminology of selected epithelial tumors

2018 ◽  
Vol 74 (1) ◽  
pp. 6040-2018
Author(s):  
Janusz A. Madej
Keyword(s):  
Nervous System ◽  
Malignant Melanoma ◽  
Blood Vessel ◽  
Tumour Cells ◽  
Lymphatic Endothelium ◽  
Neoplastic Cells ◽  
Epithelial Tumors ◽  
Clonogenic Potential ◽  
Epithelial Neoplasms ◽  
Melanoma Malignum

The types of cell cannibalism (entosis) are described (Fig. 1 and 2), including heterocannibalism and homocannibalism (autocannibalism), in which neoplastic cells can undergo incomplete heterophagocytosis, complete heterophagocytosis, pseudocannibalism, degradation to granular bodies, transformation of benign neoplastic cells into malignant ones, reduction in clonogenic potential or the progression of malignancy of tumour cells. The author also suggests changes in the nomenclature of some epithelial neoplasms, (Fig. 3) including tumours originating from blood vessel and lymphatic endothelium (from haemangioendothelioma to carcinoma haemangioendotheliae vel carcinoma lymphangiotheliale), tumours originating from the peritoneum and pleura (from mesothelioma to carcinoma mesotheliale), malignant melanoma (from melanoma malignum to melanocarcinoma, carcinoma melanogenes), thymoma (from thymomata to carcinoma thymi) and nervous system ependymoma (from ependymoma to carcinoma ependymale). .

scholarly journals Primary Intracranial Malignant Melanoma Mimicking Meningioma—Report of Two Cases

2021 ◽  
Author(s):  
Laxmikant Bhople ◽  
Hrushikesh U. Kharosekar ◽  
Harish Naik ◽  
V. Velho
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Differential Diagnosis ◽  
Malignant Melanoma ◽  
Radiological Patterns

AbstractPrimary intracranial melanoma is uncommon and accounts for only approximately 1% of all cases of melanoma. This is interesting to neuro-oncologists and neurosurgeons because the clinical and radiological patterns of these tumors can mimic the presence of meningioma. Primary central nervous system melanomas have rarely been reported with less than 25 cases reported till date. We report two cases of the primary intracranial melanoma that even though very rare should be kept as a differential diagnosis when meningioma is suspected.

A possible role for cysteine proteinase and its inhibitors in motility of malignant melanoma and other tumour cells

1992 ◽  
Vol 1 (5) ◽  
pp. 333-340 ◽  
Author(s):  
G. Boike ◽  
T. Lah ◽  
B. F. Sloane ◽  
J. Rozhin ◽  
K. Honn ◽  
...  
Keyword(s):  
Malignant Melanoma ◽  
Cysteine Proteinase ◽  
Tumour Cells

Central nervous system metastases in malignant melanoma

Neurosurgery ◽  
1981 ◽  
Vol 8 (1) ◽  
pp. 26???30 ◽  
Author(s):  
D E Bullard ◽  
E B Cox ◽  
H F Seigler
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Malignant Melanoma ◽  
Central Nervous System Metastases

A Newly Developed Mouse Monoclonal SOX10 Antibody Is a Highly Sensitive and Specific Marker for Malignant Melanoma, Including Spindle Cell and Desmoplastic Melanomas

2014 ◽  
Vol 139 (4) ◽  
pp. 530-536 ◽  
Author(s):  
David Tacha ◽  
Weimin Qi ◽  
Seong Ra ◽  
Ryan Bremer ◽  
Charlie Yu ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Malignant Melanoma ◽  
Peripheral Nerve ◽  
Immunohistochemical Staining ◽  
Spindle Cell ◽  
Breast Carcinomas ◽  
Peripheral Nerve Sheath Tumors ◽  
Highly Sensitive ◽  
Wide Range

Context Recent immunohistochemical studies have demonstrated Sry-related HMG-Box gene 10 (SOX10) expression in malignant melanomas, malignant peripheral nerve sheath tumors, a subset of breast carcinomas, and gliomas. SOX10 has shown important clinical utility in its ability to detect desmoplastic and spindle cell melanomas. To date, most publications have employed a research use–only goat polyclonal SOX10 antibody for immunohistochemical staining. Objective To describe the development of a new mouse monoclonal SOX10 antibody (BC34) and evaluate its immunohistochemical staining profile in a wide range of normal and neoplastic tissues, with an emphasis on melanoma. Design SOX10 antibody was optimized for staining using a polymer detection system and visualization with diaminobenzidine. Results In normal tissues, SOX10 was expressed in skin melanocytes and eccrine cells, breast myoepithelial and lobular epithelial cells, salivary gland myoepithelial cells, peripheral nerve Schwann cells, and central nervous system glial cells. SOX10 was expressed in 238 of 257 melanomas (92.6%), including 50 of 51 of both spindle cell and desmoplastic melanomas (98%). SOX10 was expressed in 100% of nevi (20 of 20) and schwannomas (28 of 28). In other neoplasms, SOX10 was expressed in 18 of 109 invasive ductal breast carcinomas (16.5%). All other carcinomas were negative for SOX10. SOX10 was identified in 25 of 52 central nervous system neoplasms, primarily in astrocytomas (22 of 41; 53.7%), and in 4 of 99 various sarcomas examined (4.0%). Conclusions The newly developed mouse monoclonal SOX10 antibody BC34 is highly sensitive and specific for malignant melanoma, including desmoplastic and spindle cell variants, and appears highly suitable for clinical use.

scholarly journals Evaluation of Melanogenesis in A-375 Cells in the Presence of DMSO and Analysis of Pyrolytic Profile of Isolated Melanin

2012 ◽  
Vol 2012 ◽  
pp. 1-7 ◽  
Author(s):  
Ewa Chodurek ◽  
Arkadiusz Orchel ◽  
Joanna Orchel ◽  
Sławomir Kurkiewicz ◽  
Natalia Gawlik ◽  
...  
Keyword(s):  
Malignant Melanoma ◽  
Transcriptional Activity ◽  
Chemical Compounds ◽  
Melanoma Cells ◽  
Human Melanoma ◽  
Gas Chromatography Mass Spectrometry ◽  
Pyrolysis Gas ◽  
Tyrosinase Gene ◽  
Melanoma Malignum ◽  
Morbidity Risk

The increase of a skin malignant melanoma (melanoma malignum) incidence in the world has been observed in recent years. The tumour, especially in advanced stadium with metastases, is highly resistant to conventional treatment. One of the strategies is to modulate melanogenesis using chemical compounds. In this study, the processes of differentiation and melanogenesis induced by dimethylsulfoxide (DMSO) in human melanoma cells (A-375) were investigated. Natural melanin isolated from A-375 melanoma cell line treated with 0.3% DMSO was analyzed by pyrolysis-gas chromatography-mass spectrometry (Py-GC/MS) method. The products derived from pheomelanin have not been stated in the pyrolytic profile of analyzed melanin. Within all products derived from eumelanins, 1,2-benzenediol has been predominated. It has been shown that in the melanoma cells stimulated with 0.3% and 1% DMSO, the increase of transcriptional activity of the tyrosinase gene took place. It was accompanied by the rise of tyrosinase activity and an accumulation of melanin in the cells. The better knowledge about the structure of melanins can contribute to establish the uniform criteria of malignant melanoma morbidity risk.

scholarly journals Primary malignant melanoma of the central nervous system: A diagnostic challenge

2015 ◽  
Vol 83 (2) ◽  
pp. 129-134
Author(s):  
Javier Quillo-Olvera ◽  
Juan Salvador Uribe-Olalde ◽  
Leopoldo Alberto Alcántara-Gómez ◽  
Jorge Dax Rejón-Pérez ◽  
Héctor Guillermo Palomera-Gómez
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Malignant Melanoma ◽  
Primary Malignant Melanoma ◽  
Diagnostic Challenge ◽  
System A ◽  
The Central Nervous System

Primary malignant melanoma of the central nervous system

1972 ◽  
Vol 26 (2-3) ◽  
pp. 139-149 ◽  
Author(s):  
L. Bergdahl ◽  
L. Boquist ◽  
B. Liliequist ◽  
C. -A. Thulin ◽  
D. Tovi
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Malignant Melanoma ◽  
Primary Malignant Melanoma ◽  
The Central Nervous System

scholarly journals Incidental Detection of Primary Spinal Malignant Melanoma before Central Nervous System Dissemination

2014 ◽  
Vol 1 (1) ◽  
pp. 24-27 ◽  
Author(s):  
Yoshifumi Kawanabe ◽  
Shigeo Ueda ◽  
Nobuhiro Sasaki ◽  
Minoru Hoshimaru
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Malignant Melanoma

scholarly journals Circulating tumour cells in disseminated malignant melanoma

2012 ◽  
Vol 156 (6) ◽  
pp. 692-692
Author(s):  
Chandramouli Nagarajan ◽  
Antonia Barbieri ◽  
Sajjan Mittal
Keyword(s):  
Malignant Melanoma ◽  
Tumour Cells ◽  
Circulating Tumour Cells
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