scholarly journals Incidental Detection of Primary Spinal Malignant Melanoma before Central Nervous System Dissemination

2014 ◽  
Vol 1 (1) ◽  
pp. 24-27 ◽  
Author(s):  
Yoshifumi Kawanabe ◽  
Shigeo Ueda ◽  
Nobuhiro Sasaki ◽  
Minoru Hoshimaru
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Malignant Melanoma

scholarly journals Primary Intracranial Malignant Melanoma Mimicking Meningioma—Report of Two Cases

2021 ◽  
Author(s):  
Laxmikant Bhople ◽  
Hrushikesh U. Kharosekar ◽  
Harish Naik ◽  
V. Velho
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Differential Diagnosis ◽  
Malignant Melanoma ◽  
Radiological Patterns

AbstractPrimary intracranial melanoma is uncommon and accounts for only approximately 1% of all cases of melanoma. This is interesting to neuro-oncologists and neurosurgeons because the clinical and radiological patterns of these tumors can mimic the presence of meningioma. Primary central nervous system melanomas have rarely been reported with less than 25 cases reported till date. We report two cases of the primary intracranial melanoma that even though very rare should be kept as a differential diagnosis when meningioma is suspected.

Central nervous system metastases in malignant melanoma

Neurosurgery ◽  
1981 ◽  
Vol 8 (1) ◽  
pp. 26???30 ◽  
Author(s):  
D E Bullard ◽  
E B Cox ◽  
H F Seigler
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Malignant Melanoma ◽  
Central Nervous System Metastases

A Newly Developed Mouse Monoclonal SOX10 Antibody Is a Highly Sensitive and Specific Marker for Malignant Melanoma, Including Spindle Cell and Desmoplastic Melanomas

2014 ◽  
Vol 139 (4) ◽  
pp. 530-536 ◽  
Author(s):  
David Tacha ◽  
Weimin Qi ◽  
Seong Ra ◽  
Ryan Bremer ◽  
Charlie Yu ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Malignant Melanoma ◽  
Peripheral Nerve ◽  
Immunohistochemical Staining ◽  
Spindle Cell ◽  
Breast Carcinomas ◽  
Peripheral Nerve Sheath Tumors ◽  
Highly Sensitive ◽  
Wide Range

Context Recent immunohistochemical studies have demonstrated Sry-related HMG-Box gene 10 (SOX10) expression in malignant melanomas, malignant peripheral nerve sheath tumors, a subset of breast carcinomas, and gliomas. SOX10 has shown important clinical utility in its ability to detect desmoplastic and spindle cell melanomas. To date, most publications have employed a research use–only goat polyclonal SOX10 antibody for immunohistochemical staining. Objective To describe the development of a new mouse monoclonal SOX10 antibody (BC34) and evaluate its immunohistochemical staining profile in a wide range of normal and neoplastic tissues, with an emphasis on melanoma. Design SOX10 antibody was optimized for staining using a polymer detection system and visualization with diaminobenzidine. Results In normal tissues, SOX10 was expressed in skin melanocytes and eccrine cells, breast myoepithelial and lobular epithelial cells, salivary gland myoepithelial cells, peripheral nerve Schwann cells, and central nervous system glial cells. SOX10 was expressed in 238 of 257 melanomas (92.6%), including 50 of 51 of both spindle cell and desmoplastic melanomas (98%). SOX10 was expressed in 100% of nevi (20 of 20) and schwannomas (28 of 28). In other neoplasms, SOX10 was expressed in 18 of 109 invasive ductal breast carcinomas (16.5%). All other carcinomas were negative for SOX10. SOX10 was identified in 25 of 52 central nervous system neoplasms, primarily in astrocytomas (22 of 41; 53.7%), and in 4 of 99 various sarcomas examined (4.0%). Conclusions The newly developed mouse monoclonal SOX10 antibody BC34 is highly sensitive and specific for malignant melanoma, including desmoplastic and spindle cell variants, and appears highly suitable for clinical use.

scholarly journals Primary malignant melanoma of the central nervous system: A diagnostic challenge

2015 ◽  
Vol 83 (2) ◽  
pp. 129-134
Author(s):  
Javier Quillo-Olvera ◽  
Juan Salvador Uribe-Olalde ◽  
Leopoldo Alberto Alcántara-Gómez ◽  
Jorge Dax Rejón-Pérez ◽  
Héctor Guillermo Palomera-Gómez
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Malignant Melanoma ◽  
Primary Malignant Melanoma ◽  
Diagnostic Challenge ◽  
System A ◽  
The Central Nervous System

Primary malignant melanoma of the central nervous system

1972 ◽  
Vol 26 (2-3) ◽  
pp. 139-149 ◽  
Author(s):  
L. Bergdahl ◽  
L. Boquist ◽  
B. Liliequist ◽  
C. -A. Thulin ◽  
D. Tovi
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Malignant Melanoma ◽  
Primary Malignant Melanoma ◽  
The Central Nervous System

Diagnostic Difficulties in Primary Pauci-Melanotic Leptomeningeal Melanomatosis

2018 ◽  
Vol 80 (1-2) ◽  
pp. 68-70
Author(s):  
Ewa Koziorowska-Gawron ◽  
Maciej Kaczorowski ◽  
Joanna Bladowska ◽  
Sławomir Budrewicz ◽  
Magdalena Koszewicz ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Malignant Melanoma ◽  
Rare Case ◽  
Diagnostic Procedures ◽  
Postmortem Examination ◽  
Primary Malignant Melanoma ◽  
Diagnostic Difficulties ◽  
The Central Nervous System

We present a rare case of primary malignant melanoma of the central nervous system. We underline the difficulties we faced during diagnostic procedures. Finally, postmortem examination revealed the diagnosis of primary pauci-­melanotic leptomeningeal melanomatosis.

Primary central nervous system malignant melanoma with leptomeningeal melanomatosis: a case report and review of the literature

2017 ◽  
Vol 41 (1) ◽  
pp. 333-339 ◽  
Author(s):  
Kentaro Fujimori ◽  
Keiichi Sakai ◽  
Fumiko Higashiyama ◽  
Fusakazu Oya ◽  
Toshitaka Maejima ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Case Report ◽  
Malignant Melanoma ◽  
Review Of The Literature

scholarly journals Central Nervous System Metastases of Cutaneous Malignant Melanoma: A Population-based Study

1998 ◽  
Vol 37 (5) ◽  
pp. 463-470 ◽  
Author(s):  
Gabriella Cohn-Cedermark ◽  
Eva Månsson-Brahme ◽  
Lars Erik Rutqvist ◽  
Olle Larsson ◽  
Hemming Johansson ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Malignant Melanoma ◽  
Population Based ◽  
Cutaneous Malignant Melanoma ◽  
Population Based Study ◽  
Central Nervous System Metastases
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