scholarly journals From regenerative dentistry to regenerative medicine: progress, challenges, and potential applications of oral stem cells

2014 ◽  
pp. 89 ◽  
Author(s):  
Li Xiao ◽  
Masanori Nasu
Keyword(s):  
Stem Cells ◽  
Regenerative Medicine ◽  
Regenerative Dentistry ◽  
Potential Applications ◽  
Oral Stem Cells

Morpholino-functionalized phosphorus dendrimers for precision regenerative medicine: osteogenic differentiation of mesenchymal stem cells

Nanoscale ◽  
2019 ◽  
Vol 11 (37) ◽  
pp. 17230-17234
Author(s):  
Aijun Li ◽  
Yu Fan ◽  
Xueyan Cao ◽  
Liang Chen ◽  
Le Wang ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Regenerative Medicine ◽  
Bone Regeneration ◽  
Osteogenic Differentiation ◽  
Potential Applications

Morpholino-functionalized phosphorus dendrimers strongly promote the transformation of mesenchymal stem cells into osteoblasts for potential applications in bone regeneration.

scholarly journals Generation and Applications of Induced Pluripotent Stem Cell-Derived Mesenchymal Stem Cells

2018 ◽  
Vol 2018 ◽  
pp. 1-8 ◽  
Author(s):  
Chengzhu Zhao ◽  
Makoto Ikeya
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Regenerative Medicine ◽  
Pluripotent Stem Cells ◽  
Adult Stem Cells ◽  
Disease Modeling ◽  
Induced Pluripotent Stem Cell ◽  
Potential Applications ◽  
Induced Pluripotent ◽  
Number Of Publications

Mesenchymal stem cells (MSCs) are adult stem cells with fibroblast-like morphology and isolated from the bone marrow via plastic adhesion. Their multipotency and immunoregulatory properties make MSCs possible therapeutic agents, and an increasing number of publications and clinical trials have highlighted their potential in regenerative medicine. However, the finite proliferative capacity of MSCs limits their scalability and global dissemination as a standardized therapeutic product. Furthermore, adult tissue provenance could constrain accessibility, impinge on cellular potency, and incur greater exposure to disease-causing pathogens based on the donor. These issues could be circumvented by the derivation of MSCs from pluripotent stem cells. In this paper, we review methods that induce and characterize MSCs derived from induced pluripotent stem cells (iPSCs) and introduce MSC applications to disease modeling, pathogenic mechanisms, and drug discovery. We also discuss the potential applications of MSCs in regenerative medicine including cell-based therapies and issues that should be overcome before iPSC-derived MSC therapy will be applied in the clinic.

scholarly journals Innovative Dental Stem Cell-Based Research Approaches: The Future of Dentistry

2016 ◽  
Vol 2016 ◽  
pp. 1-7 ◽  
Author(s):  
Shayee Miran ◽  
Thimios A. Mitsiadis ◽  
Pierfrancesco Pagella
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Cell Biology ◽  
Adult Stem Cell ◽  
Cell Types ◽  
Dental Tissues ◽  
Periodontal Tissues ◽  
Tissue Repair And Regeneration ◽  
Regenerative Dentistry ◽  
Potential Applications

Over the past decade, the dental field has benefited from recent findings in stem cell biology and tissue engineering that led to the elaboration of novel ideas and concepts for the regeneration of dental tissues or entire new teeth. In particular, stem cell-based regenerative approaches are extremely promising since they aim at the full restoration of lost or damaged tissues, ensuring thus their functionality. These therapeutic approaches are already applied with success in clinics for the regeneration of other organs and consist of manipulation of stem cells and their administration to patients. Stem cells have the potential to self-renew and to give rise to a variety of cell types that ensure tissue repair and regeneration throughout life. During the last decades, several adult stem cell populations have been isolated from dental and periodontal tissues, characterized, and tested for their potential applications in regenerative dentistry. Here we briefly present the various stem cell-based treatment approaches and strategies that could be translated in dental practice and revolutionize dentistry.

scholarly journals Induced Pluripotent Stem Cells in Dental and Nondental Tissue Regeneration: A Review of an Unexploited Potential

2020 ◽  
Vol 2020 ◽  
pp. 1-24 ◽  
Author(s):  
Israa Ahmed Radwan ◽  
Dina Rady ◽  
Marwa M. S. Abbass ◽  
Sara El Moshy ◽  
Nermeen AbuBakr ◽  
...  
Keyword(s):  
Stem Cells ◽  
Regenerative Medicine ◽  
Induced Pluripotent Stem Cells ◽  
Tissue Regeneration ◽  
Pluripotent Stem Cells ◽  
Disease Modeling ◽  
Potential Applications ◽  
Induced Pluripotent

Cell-based therapies currently represent the state of art for tissue regenerative treatment approaches for various diseases and disorders. Induced pluripotent stem cells (iPSCs), reprogrammed from adult somatic cells, using vectors carrying definite transcription factors, have manifested a breakthrough in regenerative medicine, relying on their pluripotent nature and ease of generation in large amounts from various dental and nondental tissues. In addition to their potential applications in regenerative medicine and dentistry, iPSCs can also be used in disease modeling and drug testing for personalized medicine. The current review discusses various techniques for the production of iPSC-derived osteogenic and odontogenic progenitors, the therapeutic applications of iPSCs, and their regenerative potential in vivo and in vitro. Through the present review, we aim to explore the potential applications of iPSCs in dental and nondental tissue regeneration and to highlight different protocols used for the generation of different tissues and cell lines from iPSCs.

scholarly journals Pharmacological Regulation of Oxidative Stress in Stem Cells

2018 ◽  
Vol 2018 ◽  
pp. 1-13 ◽  
Author(s):  
Jungwoon Lee ◽  
Yee Sook Cho ◽  
Haiyoung Jung ◽  
Inpyo Choi
Keyword(s):  
Oxidative Stress ◽  
Stem Cells ◽  
Stem Cell ◽  
Regenerative Medicine ◽  
Defense Mechanisms ◽  
Stem Cell Differentiation ◽  
Self Renewal ◽  
Hematopoietic Stem ◽  
Potential Applications ◽  
Cellular Oxidation

Oxidative stress results from an imbalance between reactive oxygen species (ROS) production and antioxidant defense mechanisms. The regulation of stem cell self-renewal and differentiation is crucial for early development and tissue homeostasis. Recent reports have suggested that the balance between self-renewal and differentiation is regulated by the cellular oxidation-reduction (redox) state; therefore, the study of ROS regulation in regenerative medicine has emerged to develop protocols for regulating appropriate stem cell differentiation and maintenance for clinical applications. In this review, we introduce the defined roles of oxidative stress in pluripotent stem cells (PSCs) and hematopoietic stem cells (HSCs) and discuss the potential applications of pharmacological approaches for regulating oxidative stress in regenerative medicine.

scholarly journals МЕЗЕНХІМАЛЬНІ СТОВБУРОВІ КЛІТИНИ ОДОНТОГЕННОГО ПОХОДЖЕННЯ: ПЕРСПЕКТИВИ ТА МОЖЛИВОСТІ РЕГЕНЕРАТИВНОЇ МЕДИЦИНИ

2021 ◽  
Vol 116 (3) ◽  
pp. 33-40
Author(s):  
О.І. Годованець ◽  
К.Л. Гальчук ◽  
Т.І. Муринюк ◽  
Е.О. Саука
Keyword(s):  
Tissue Engineering ◽  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Stem Cell ◽  
Regenerative Medicine ◽  
Cell Therapy ◽  
Stem Cell Therapy ◽  
Web Of Science ◽  
Regenerative Dentistry

Мета: Провести аналіз літературних джерел у напрямку науково-теоретичних та клінічних аспек- тів щодо можливостей використання мезенхімаль- них стовбурових клітин, отриманих з різних джерел щелепно-лицевої ділянки. Матеріали і методи: Під час дослідження викорис- тано бібліосемантичний метод та структурно-логіч- ний аналіз. Для пошуку сучасної наукової літератури були використані електронні бази даних PubMed, MEDLINE, Scopus, Web of Science та EMBASE за клю- човими словами «regenerative medicine», «regenerative dentistry», «stem cells», «dental mesenchymal stem cells», «stem cell therapy», «tissue engineering». Висновки: На основі проведеного аналізу літера- тури прослідковується неабиякий інтерес науковців до стовбурових клітин одонтогенного походження та їх використання у регенеративній практиці не лише стоматологічного спрямування, але і для ліку- вання соматичних хвороб різного генезу. Це пов’язано із неінвазивним та більш простим методом забору матеріалу, порівняно із кістковим мозком людини чи ембріональними тканинами. Стовбурові клітини різ- няться за походженням, диференційною активністю та джерелом їх отримання, а також мають ваго- мий потенціал до диференціації за напрямком різних клітинних ліній залежно від впливу факторів росту та живильного середовища. При одержанні нових чистих культур вдається встановити їх походження шляхом ідентифікації експресії маркерів, характерних для стовбурових клітин. Тим не менш, незважаючи на високі очікування від подальшого розвитку реге- неративної терапії, науковцям необхідно детальніше вивчити можливості використання цих клітин на етапах клінічного випробування, дослідити імуноло- гічну поведінку стовбурових клітин одонтогенного походження в тому чи іншому середовищі.

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