scholarly journals Synthesis molecular modeling and anticonvulsant activity of some hydrazone, semicarbazone, and thiosemicarbazone derivatives of benzylidene camphor

2014 ◽  
pp. 47
Author(s):  
Saurabh Agrawal ◽  
Jainedra Jain ◽  
Ankit Kumar ◽  
Pratibha Gupta ◽  
Vikas Garg
Keyword(s):  
Molecular Modeling ◽  
Anticonvulsant Activity ◽  
Derivatives Of

Anticonvulsant Activity and 5-HT1A/5-HT7 Receptors Affinity of Piperazine Derivatives of 3,3-Diphenyl- and 3,3-Dimethyl-succinimides

2012 ◽  
Vol 10 (2) ◽  
pp. 173-182 ◽  
Author(s):  
Jolanta Obniska ◽  
Iwona Chlebek ◽  
Krzysztof Kaminski ◽  
Andrzej J.Bojarski ◽  
Grzegorz Satala
Keyword(s):  
Anticonvulsant Activity ◽  
Piperazine Derivatives ◽  
Derivatives Of

Lacosamide Derivatives with Anticonvulsant Activity as Carbonic Anhydrase Inhibitors. Molecular Modeling, Docking and QSAR Analysis

2014 ◽  
Vol 10 (2) ◽  
pp. 160-167 ◽  
Author(s):  
Juan Martinez ◽  
Esteban Vega-Hissi ◽  
Matias Andrada ◽  
Pablo Duchowicz ◽  
Francisco Torrens ◽  
...  
Keyword(s):  
Molecular Modeling ◽  
Carbonic Anhydrase ◽  
Anticonvulsant Activity ◽  
Carbonic Anhydrase Inhibitors ◽  
Qsar Analysis

scholarly journals Synthesis and anticonvulsant activity of 6-methyl-2-((2-oxo-2-arylethyl)thio)pyrimidin-4(3 H)-one derivatives and products of their cyclization

Pharmacia ◽  
2019 ◽  
Vol 66 (3) ◽  
pp. 141-146
Author(s):  
Hanna Severina ◽  
Olga O. Skupa ◽  
Natalya I. Voloshchuk ◽  
Marharyta M. Suleiman ◽  
Victoriya A. Georgiyants
Keyword(s):  
Sulphuric Acid ◽  
Anticonvulsant Activity ◽  
Sodium Methoxide ◽  
Structure Activity ◽  
Phenacyl Bromides ◽  
Pharmacological Screening ◽  
High Yields ◽  
Derivatives Of

The alkylation of 6-methyl-2-thioxo-2,3-dihydro-1H-pyrimidine-4-one phenacyl bromides under different conditions was investigated. It was found that during the reaction in the medium of DMF/K2CO3 a mixture of 2-(2-aryl-2-oxoethyl)thio-6-methyl-pyrimidine-4(3H)-one and 3-hydroxy-3-aryl-7-methyl-2,3-dihydro-5H-thiazolo[3,2-a]pyrimidine-5-one was formed. The holding of the resulting mixture in the concentrated sulphuric acid leads to the formation of cyclization products - derivatives of 3-aryl-7-methyl-5H-thiazolo[3,2-a]pyrimidin-5-one with high yields. Individual S-alkylated derivatives – 2-(2-aryl-2-oxoethyl)thio-6-methyl-pyrimidine-4(3H)-one - were obtained by reacting in methanol in the presence of sodium methoxide. Pharmacological screening of synthesized compounds for anticonvulsant activity on the model of pentylenetetrazole seizures in rats was carried out and some regularity “structure-activity” was established.

ChemInform Abstract: SYNTHESIS AND PROPERTIES OF NEW CYCLIC DERIVATIVES OF SUCCINIC ACID WITH ANTICONVULSANT ACTIVITY

1977 ◽  
Vol 8 (28) ◽  
pp. no-no
Author(s):  
J. LANGE ◽  
S. RUMP ◽  
E. GALECKA ◽  
L. ILCZUK ◽  
M. LECHOWSKA-POSTEK ◽  
...  
Keyword(s):  
Succinic Acid ◽  
Anticonvulsant Activity ◽  
Derivatives Of

Design, synthesis, and anticonvulsant activity of some derivatives of xanthone with aminoalkanol moieties

2016 ◽  
Vol 89 (3) ◽  
pp. 339-352 ◽  
Author(s):  
Anna M. Waszkielewicz ◽  
Karolina Słoczyńska ◽  
Elżbieta Pękala ◽  
Paweł Żmudzki ◽  
Agata Siwek ◽  
...  
Keyword(s):  
Anticonvulsant Activity ◽  
Design Synthesis ◽  
Derivatives Of

Derivatives of Imidazole. I. Synthesis and Reactions of Imidazo[1,2-α]pyridines with Analgesic, Antiinflammatory, Antipyretic, and Anticonvulsant Activity

1965 ◽  
Vol 8 (3) ◽  
pp. 305-312 ◽  
Author(s):  
Luigi Almirante ◽  
Luigi Polo ◽  
Alfonso Mugnaini ◽  
Ercolina Provinciali ◽  
Pierluigi Rugarli ◽  
...  
Keyword(s):  
Anticonvulsant Activity ◽  
Derivatives Of
Sign in / Sign up

Export Citation Format

Share Document