Derivatives of Imidazole. I. Synthesis and Reactions of Imidazo[1,2-α]pyridines with Analgesic, Antiinflammatory, Antipyretic, and Anticonvulsant Activity

1965 ◽  
Vol 8 (3) ◽  
pp. 305-312 ◽  
Author(s):  
Luigi Almirante ◽  
Luigi Polo ◽  
Alfonso Mugnaini ◽  
Ercolina Provinciali ◽  
Pierluigi Rugarli ◽  
...  
Keyword(s):  
Anticonvulsant Activity ◽  
Derivatives Of

Anticonvulsant Activity and 5-HT1A/5-HT7 Receptors Affinity of Piperazine Derivatives of 3,3-Diphenyl- and 3,3-Dimethyl-succinimides

2012 ◽  
Vol 10 (2) ◽  
pp. 173-182 ◽  
Author(s):  
Jolanta Obniska ◽  
Iwona Chlebek ◽  
Krzysztof Kaminski ◽  
Andrzej J.Bojarski ◽  
Grzegorz Satala
Keyword(s):  
Anticonvulsant Activity ◽  
Piperazine Derivatives ◽  
Derivatives Of

scholarly journals Synthesis and anticonvulsant activity of 6-methyl-2-((2-oxo-2-arylethyl)thio)pyrimidin-4(3 H)-one derivatives and products of their cyclization

Pharmacia ◽  
2019 ◽  
Vol 66 (3) ◽  
pp. 141-146
Author(s):  
Hanna Severina ◽  
Olga O. Skupa ◽  
Natalya I. Voloshchuk ◽  
Marharyta M. Suleiman ◽  
Victoriya A. Georgiyants
Keyword(s):  
Sulphuric Acid ◽  
Anticonvulsant Activity ◽  
Sodium Methoxide ◽  
Structure Activity ◽  
Phenacyl Bromides ◽  
Pharmacological Screening ◽  
High Yields ◽  
Derivatives Of

The alkylation of 6-methyl-2-thioxo-2,3-dihydro-1H-pyrimidine-4-one phenacyl bromides under different conditions was investigated. It was found that during the reaction in the medium of DMF/K2CO3 a mixture of 2-(2-aryl-2-oxoethyl)thio-6-methyl-pyrimidine-4(3H)-one and 3-hydroxy-3-aryl-7-methyl-2,3-dihydro-5H-thiazolo[3,2-a]pyrimidine-5-one was formed. The holding of the resulting mixture in the concentrated sulphuric acid leads to the formation of cyclization products - derivatives of 3-aryl-7-methyl-5H-thiazolo[3,2-a]pyrimidin-5-one with high yields. Individual S-alkylated derivatives – 2-(2-aryl-2-oxoethyl)thio-6-methyl-pyrimidine-4(3H)-one - were obtained by reacting in methanol in the presence of sodium methoxide. Pharmacological screening of synthesized compounds for anticonvulsant activity on the model of pentylenetetrazole seizures in rats was carried out and some regularity “structure-activity” was established.

ChemInform Abstract: SYNTHESIS AND PROPERTIES OF NEW CYCLIC DERIVATIVES OF SUCCINIC ACID WITH ANTICONVULSANT ACTIVITY

1977 ◽  
Vol 8 (28) ◽  
pp. no-no
Author(s):  
J. LANGE ◽  
S. RUMP ◽  
E. GALECKA ◽  
L. ILCZUK ◽  
M. LECHOWSKA-POSTEK ◽  
...  
Keyword(s):  
Succinic Acid ◽  
Anticonvulsant Activity ◽  
Derivatives Of

Design, synthesis, and anticonvulsant activity of some derivatives of xanthone with aminoalkanol moieties

2016 ◽  
Vol 89 (3) ◽  
pp. 339-352 ◽  
Author(s):  
Anna M. Waszkielewicz ◽  
Karolina Słoczyńska ◽  
Elżbieta Pękala ◽  
Paweł Żmudzki ◽  
Agata Siwek ◽  
...  
Keyword(s):  
Anticonvulsant Activity ◽  
Design Synthesis ◽  
Derivatives Of

ChemInform Abstract: SYNTHESIS AND PROPERTIES OF CYCLIC DERIVATIVES OF SUCCINIC ACID WITH ANTICONVULSANT ACTIVITY. PART 4

1984 ◽  
Vol 15 (41) ◽  
Author(s):  
J. LANGE ◽  
S. RUMP ◽  
G. BORKOWSKA ◽  
M. KOWALCZYK ◽  
J. LAPSZEWICZ ◽  
...  
Keyword(s):  
Succinic Acid ◽  
Anticonvulsant Activity ◽  
Derivatives Of

Synthesis and Anticonvulsant Activity of Derivatives of Pyrano[4′,3′:4,5]pyrido[2,3-b]furo[3,2-d]pyrimidine and Pyrano[4′,3′:4,5]pyrido[2,3-b]furo[3,2-d]pyridine.

ChemInform ◽  
2003 ◽  
Vol 34 (3) ◽  
Author(s):  
E. G. Paronikyan ◽  
A. Kh. Oganisyan ◽  
A. S. Noravyan ◽  
R. G. Paronikyan ◽  
I. A. Dzhagatspanyan
Keyword(s):  
Anticonvulsant Activity ◽  
Derivatives Of

Synthesis, characterization & anticonvulsant activity of amide derivatives of 4-amino-1,2-naphthoquinone

2013 ◽  
Vol 22 (11) ◽  
pp. 5349-5355 ◽  
Author(s):  
Mukesh Bansal ◽  
Bharat Goel ◽  
Shubhanjali Shukla ◽  
Radhey Shyam Srivastava
Keyword(s):  
Anticonvulsant Activity ◽  
Amide Derivatives ◽  
Derivatives Of
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