scholarly journals Association of MDM4 Gene rs4245739 Polymorphism with the Risk and Clinical Characteristics of Colorectal Cancer in a Chinese Han Population

2020 ◽  
Vol Volume 13 ◽  
pp. 673-678
Author(s):  
De-Ming Zhao ◽  
Yu-E Diao ◽  
Qing Xu
Keyword(s):  
Colorectal Cancer ◽  
Clinical Characteristics ◽  
Chinese Han Population ◽  
Chinese Han ◽  
Han Population ◽  
Em Gene

scholarly journals Impact of polymorphisms in DNA repair genes XPD, hOGG1 and XRCC4 on colorectal cancer risk in a Chinese Han Population

2019 ◽  
Vol 39 (1) ◽  
Author(s):  
Dexi Jin ◽  
Min Zhang ◽  
Hongjun Hua
Keyword(s):  
Colorectal Cancer ◽  
Gene Polymorphisms ◽  
Colorectal Carcinogenesis ◽  
Chinese Han Population ◽  
Control Group ◽  
Chinese Han ◽  
Han Population ◽  
Increased Risk ◽  
Hogg1 Gene ◽  
Repair Genes

Abstract Background: This research aimed to study the associations between XPD (G751A, rs13181), hOGG1 (C326G, rs1052133) and XRCC4 (G1394T, rs6869366) gene polymorphisms and the risk of colorectal cancer (CRC) in a Chinese Han population. Method: A total of 225 Chinese Han patients with CRC were selected as the study group, and 200 healthy subjects were recruited as the control group. The polymorphisms of XPD G751A, hOGG1 C326G and XRCC4 G1394T loci were detected by the RFLP-PCR technique in the peripheral blood of all subjects. Results: Compared with individuals carrying the XPD751 GG allele, the A allele carriers (GA/AA) had a significantly increased risk of CRC (adjusted OR = 2.109, 95%CI = 1.352–3.287, P=0.003). Similarly, the G allele (CG/GG) of hOGG1 C326G locus conferred increased susceptibility to CRC (adjusted OR = 2.654, 95%CI = 1.915–3.685, P<0.001). In addition, the T allele carriers (GT/TT) of the XRCC4 G1394T locus have an increased risk of developing CRC (adjusted OR = 4.512, 95%CI = 2.785–7.402, P<0.001). The risk of CRC was significantly increased in individuals with both the XPD locus A allele and the hOGG1 locus G allele (adjusted OR = 1.543, 95%CI = 1.302–2.542, P=0.002). Furthermore, individuals with both the hOGG1 locus G allele and the XRCC4 locus T allele were predisposed to CRC development (adjusted OR = 3.854, 95%CI = 1.924–7.123, P<0.001). The risks of CRC in XPD gene A allele carriers (GA/AA) (adjusted OR = 1.570, 95%CI = 1.201–1.976, P=0.001), hOGG1 gene G allele carriers (CG/GG) (adjusted OR = 3.031, 95%CI = 2.184–4.225, P<0.001) and XRCC4 gene T allele carriers (GT/TT) (adjusted OR = 2.793, 95%CI = 2.235–3.222, P<0.001) were significantly higher in patients who smoked ≥16 packs/year. Conclusion: Our results suggest that XPD G751A, hOGG1 C326G and XRCC4 G1394T gene polymorphisms might play an important role in colorectal carcinogenesis and increase the risk of developing CRC in the Chinese Han population. The interaction between smoking and these gene polymorphisms would increase the risk of CRC.

scholarly journals Prediction of gastric cancer risk: association between ZBTB20 genetic variance and gastric cancer risk in Chinese Han population

2020 ◽  
Vol 40 (9) ◽  
Author(s):  
Fei Bai ◽  
Ke Xiao
Keyword(s):  
Gastric Cancer ◽  
Cancer Risk ◽  
Clinical Characteristics ◽  
Protective Factor ◽  
Univariate Analysis ◽  
Genetic Models ◽  
Chinese Han Population ◽  
Gastric Cancer Risk ◽  
Chinese Han ◽  
Han Population

Abstract Background: Gastric cancer (GC) is a complex multifactorial disease. Previous studies have revealed genetic variations associated with the risk of gastric cancer. The purpose of the present study was to determine the correlation between single-nucleotide polymorphisms (SNPs) of ZBTB20 and the risk of gastric cancer in Chinese Han population. Methods: We conducted a ‘case–control’ study involving 509 GC patients and 507 healthy individuals. We selected four SNPs of ZBTB20 (10934270 T/C, rs9288999 G/A, rs9841504 G/C and rs73230612 C/T), and used logistic regression to analyze the relationship between those SNPs and GC risk under different genetic models; multi-factor dimensionality reduction (MDR) was used to analyze the interaction of “SNP–SNP” in gastric cancer risk; ANOVA and univariate analysis were used to analyze the differences in clinical characteristics among different genotypes. Results: Our results showed that ZBTB20 rs9288999 is a protective factor for the risk of gastric cancer in multiple genetic models, of which the homozygous model is the most significant (OR = 0.48, P=0.0003); we also found that rs9288999 showed a significant correlation with reducing the risk of gastric cancer in different subgroups (BMI; age; gender; smoking or drinking status; adenocarcinoma); rs9841504 is associated with increased GC risk in the participants with BMI&gt;24 kg/m2; rs9841504 and rs73230612 are certainly associated with clinical characteristics of platelet and carbohydrate antigen 242, respectively. Conclusion: Our results suggest that ZBTB20 rs9288999 may be important for reducing the risk of GC in the Chinese Han population.

XRCC1 R399Q polymorphism and colorectal cancer risk in the Chinese Han population: a meta-analysis

Tumor Biology ◽  
2015 ◽  
Vol 36 (2) ◽  
pp. 461-466 ◽  
Author(s):  
Chang-Jiang Qin ◽  
Kai-Wu Xu ◽  
Zhi-Hui Chen ◽  
Er-Tao Zhai ◽  
Yu-Long He ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Risk ◽  
Meta Analysis ◽  
Colorectal Cancer Risk ◽  
Chinese Han Population ◽  
Chinese Han ◽  
Han Population

FOXP3 rs2280883 polymorphism confers susceptibility to colorectal cancer in a Chinese Han population

Gene ◽  
2020 ◽  
Vol 734 ◽  
pp. 144395
Author(s):  
Ying Lou ◽  
Minhui Fan ◽  
Renya Shuai ◽  
Cheng Yao
Keyword(s):  
Colorectal Cancer ◽  
Chinese Han Population ◽  
Chinese Han ◽  
Han Population

scholarly journals Genetic polymorphisms in the telomere length-related gene ACYP2 are associated with the risk of colorectal cancer in a Chinese Han population

Oncotarget ◽  
2016 ◽  
Vol 8 (6) ◽  
pp. 9849-9857 ◽  
Author(s):  
Fang Liu ◽  
Zhongguo Zhang ◽  
Yong Zhang ◽  
Yue Chen ◽  
Xiaoyu Yang ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Telomere Length ◽  
Genetic Polymorphisms ◽  
Chinese Han Population ◽  
Related Gene ◽  
Chinese Han ◽  
Han Population

scholarly journals Association between ADORA2A gene polymorphisms and schizophrenia in the North Chinese Han population

2019 ◽  
Vol Volume 15 ◽  
pp. 2451-2458
Author(s):  
Junxiao Miao ◽  
Lu Liu ◽  
Ci Yan ◽  
Xiaotong Zhu ◽  
Mengqi Fan ◽  
...  
Keyword(s):  
Gene Polymorphisms ◽  
Chinese Han Population ◽  
Chinese Han ◽  
Han Population ◽  
The North ◽  
Em Gene

6025 POSTER Association Between ESR1 and ESR2 Polymorphisms and Risk of Colorectal Cancer in Chinese Han Population

2011 ◽  
Vol 47 ◽  
pp. S399
Author(s):  
H.L. Wu ◽  
X.L. Yuan ◽  
H.H. Xiong ◽  
G.Y. Hu ◽  
J. Cai ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Chinese Han Population ◽  
Chinese Han ◽  
Han Population
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