scholarly journals Genetic polymorphisms in the telomere length-related gene ACYP2 are associated with the risk of colorectal cancer in a Chinese Han population

Oncotarget ◽  
2016 ◽  
Vol 8 (6) ◽  
pp. 9849-9857 ◽  
Author(s):  
Fang Liu ◽  
Zhongguo Zhang ◽  
Yong Zhang ◽  
Yue Chen ◽  
Xiaoyu Yang ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Telomere Length ◽  
Genetic Polymorphisms ◽  
Chinese Han Population ◽  
Related Gene ◽  
Chinese Han ◽  
Han Population

scholarly journals Relationship between the TERT, TNIP1 and OBFC1 genetic polymorphisms and susceptibility to colorectal cancer in Chinese Han population

Oncotarget ◽  
2017 ◽  
Vol 8 (34) ◽  
pp. 56932-56941 ◽  
Author(s):  
Chuang Li ◽  
Zixuan Zhao ◽  
Jun Zhou ◽  
Ying Liu ◽  
Hao Wang ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Genetic Polymorphisms ◽  
Chinese Han Population ◽  
Chinese Han ◽  
Han Population

Association between the IFN-γ and IL-1 genetic polymorphisms and colorectal cancer in the Chinese Han population

2014 ◽  
Vol 93 (1) ◽  
pp. 235-239 ◽  
Author(s):  
BAO-YING FEI ◽  
HUO-XIANG LV ◽  
YONG-WEI CHENG ◽  
JIANG-MING YANG
Keyword(s):  
Colorectal Cancer ◽  
Genetic Polymorphisms ◽  
Chinese Han Population ◽  
Chinese Han ◽  
Han Population ◽  
Ifn Γ

scholarly journals Association analysis of telomere length related gene ACYP2 with the gastric cancer risk in the northwest Chinese Han population

Oncotarget ◽  
2017 ◽  
Vol 8 (19) ◽  
pp. 31144-31152 ◽  
Author(s):  
Jianhui Li ◽  
Gang Ma ◽  
Xulong Zhu ◽  
Tianbo Jin ◽  
Jianxiong Wang ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Risk ◽  
Telomere Length ◽  
Association Analysis ◽  
Chinese Han Population ◽  
Related Gene ◽  
Gastric Cancer Risk ◽  
Chinese Han ◽  
Han Population

Association of KIF21B genetic polymorphisms with ankylosing spondylitis in a Chinese Han population of Shandong Province

2014 ◽  
Vol 34 (10) ◽  
pp. 1729-1736 ◽  
Author(s):  
Xinglin Yang ◽  
Ming Li ◽  
Liya Wang ◽  
Zhongdan Hu ◽  
Yuanchao Zhang ◽  
...  
Keyword(s):  
Ankylosing Spondylitis ◽  
Genetic Polymorphisms ◽  
Shandong Province ◽  
Chinese Han Population ◽  
Chinese Han ◽  
Han Population

scholarly journals Impact of polymorphisms in DNA repair genes XPD, hOGG1 and XRCC4 on colorectal cancer risk in a Chinese Han Population

2019 ◽  
Vol 39 (1) ◽  
Author(s):  
Dexi Jin ◽  
Min Zhang ◽  
Hongjun Hua
Keyword(s):  
Colorectal Cancer ◽  
Gene Polymorphisms ◽  
Colorectal Carcinogenesis ◽  
Chinese Han Population ◽  
Control Group ◽  
Chinese Han ◽  
Han Population ◽  
Increased Risk ◽  
Hogg1 Gene ◽  
Repair Genes

Abstract Background: This research aimed to study the associations between XPD (G751A, rs13181), hOGG1 (C326G, rs1052133) and XRCC4 (G1394T, rs6869366) gene polymorphisms and the risk of colorectal cancer (CRC) in a Chinese Han population. Method: A total of 225 Chinese Han patients with CRC were selected as the study group, and 200 healthy subjects were recruited as the control group. The polymorphisms of XPD G751A, hOGG1 C326G and XRCC4 G1394T loci were detected by the RFLP-PCR technique in the peripheral blood of all subjects. Results: Compared with individuals carrying the XPD751 GG allele, the A allele carriers (GA/AA) had a significantly increased risk of CRC (adjusted OR = 2.109, 95%CI = 1.352–3.287, P=0.003). Similarly, the G allele (CG/GG) of hOGG1 C326G locus conferred increased susceptibility to CRC (adjusted OR = 2.654, 95%CI = 1.915–3.685, P<0.001). In addition, the T allele carriers (GT/TT) of the XRCC4 G1394T locus have an increased risk of developing CRC (adjusted OR = 4.512, 95%CI = 2.785–7.402, P<0.001). The risk of CRC was significantly increased in individuals with both the XPD locus A allele and the hOGG1 locus G allele (adjusted OR = 1.543, 95%CI = 1.302–2.542, P=0.002). Furthermore, individuals with both the hOGG1 locus G allele and the XRCC4 locus T allele were predisposed to CRC development (adjusted OR = 3.854, 95%CI = 1.924–7.123, P<0.001). The risks of CRC in XPD gene A allele carriers (GA/AA) (adjusted OR = 1.570, 95%CI = 1.201–1.976, P=0.001), hOGG1 gene G allele carriers (CG/GG) (adjusted OR = 3.031, 95%CI = 2.184–4.225, P<0.001) and XRCC4 gene T allele carriers (GT/TT) (adjusted OR = 2.793, 95%CI = 2.235–3.222, P<0.001) were significantly higher in patients who smoked ≥16 packs/year. Conclusion: Our results suggest that XPD G751A, hOGG1 C326G and XRCC4 G1394T gene polymorphisms might play an important role in colorectal carcinogenesis and increase the risk of developing CRC in the Chinese Han population. The interaction between smoking and these gene polymorphisms would increase the risk of CRC.

Genetic polymorphisms of 20 STR loci in Chinese Han population in Tianjin, North China

2013 ◽  
Vol 4 (1) ◽  
pp. e192-e193 ◽  
Author(s):  
Bin Wang ◽  
Jinzhi Kuang ◽  
Yan Ma ◽  
Guimin Wang ◽  
Wei Zhu ◽  
...  
Keyword(s):  
Genetic Polymorphisms ◽  
North China ◽  
Chinese Han Population ◽  
Chinese Han ◽  
Han Population ◽  
Str Loci

XRCC1 R399Q polymorphism and colorectal cancer risk in the Chinese Han population: a meta-analysis

Tumor Biology ◽  
2015 ◽  
Vol 36 (2) ◽  
pp. 461-466 ◽  
Author(s):  
Chang-Jiang Qin ◽  
Kai-Wu Xu ◽  
Zhi-Hui Chen ◽  
Er-Tao Zhai ◽  
Yu-Long He ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Risk ◽  
Meta Analysis ◽  
Colorectal Cancer Risk ◽  
Chinese Han Population ◽  
Chinese Han ◽  
Han Population

Telomere length-related geneACYP2polymorphism is associated with the risk of HAPE in Chinese Han population

2016 ◽  
Vol 18 (9) ◽  
pp. 244-249 ◽  
Author(s):  
Yongjun He ◽  
Xiyang Zhang ◽  
Xun Li ◽  
Jieli Du ◽  
Xue He ◽  
...  
Keyword(s):  
Telomere Length ◽  
Chinese Han Population ◽  
Chinese Han ◽  
Han Population
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