Aetiology and clinical characteristics of patients with bronchiectasis in a Chinese Han population: A prospective study

Respirology ◽  
2015 ◽  
Vol 20 (6) ◽  
pp. 917-924 ◽  
Author(s):  
Qian Qi ◽  
Wen Wang ◽  
Tao Li ◽  
Yan Zhang ◽  
Yu Li
Keyword(s):  
Prospective Study ◽  
Clinical Characteristics ◽  
Chinese Han Population ◽  
Chinese Han ◽  
Han Population ◽  
A Prospective Study

scholarly journals Prediction of gastric cancer risk: association between ZBTB20 genetic variance and gastric cancer risk in Chinese Han population

2020 ◽  
Vol 40 (9) ◽  
Author(s):  
Fei Bai ◽  
Ke Xiao
Keyword(s):  
Gastric Cancer ◽  
Cancer Risk ◽  
Clinical Characteristics ◽  
Protective Factor ◽  
Univariate Analysis ◽  
Genetic Models ◽  
Chinese Han Population ◽  
Gastric Cancer Risk ◽  
Chinese Han ◽  
Han Population

Abstract Background: Gastric cancer (GC) is a complex multifactorial disease. Previous studies have revealed genetic variations associated with the risk of gastric cancer. The purpose of the present study was to determine the correlation between single-nucleotide polymorphisms (SNPs) of ZBTB20 and the risk of gastric cancer in Chinese Han population. Methods: We conducted a ‘case–control’ study involving 509 GC patients and 507 healthy individuals. We selected four SNPs of ZBTB20 (10934270 T/C, rs9288999 G/A, rs9841504 G/C and rs73230612 C/T), and used logistic regression to analyze the relationship between those SNPs and GC risk under different genetic models; multi-factor dimensionality reduction (MDR) was used to analyze the interaction of “SNP–SNP” in gastric cancer risk; ANOVA and univariate analysis were used to analyze the differences in clinical characteristics among different genotypes. Results: Our results showed that ZBTB20 rs9288999 is a protective factor for the risk of gastric cancer in multiple genetic models, of which the homozygous model is the most significant (OR = 0.48, P=0.0003); we also found that rs9288999 showed a significant correlation with reducing the risk of gastric cancer in different subgroups (BMI; age; gender; smoking or drinking status; adenocarcinoma); rs9841504 is associated with increased GC risk in the participants with BMI>24 kg/m2; rs9841504 and rs73230612 are certainly associated with clinical characteristics of platelet and carbohydrate antigen 242, respectively. Conclusion: Our results suggest that ZBTB20 rs9288999 may be important for reducing the risk of GC in the Chinese Han population.

Socio-demographic and clinical characteristics of heavy and non-heavy smokers among schizophrenia inpatients in a Chinese Han population

2013 ◽  
Vol 231 (1) ◽  
pp. 305-314 ◽  
Author(s):  
Xiang Yang Zhang ◽  
Da Chun Chen ◽  
Yun Long Tan ◽  
Mei Hong Xiu ◽  
Jingyi Cui ◽  
...  
Keyword(s):  
Clinical Characteristics ◽  
Chinese Han Population ◽  
Chinese Han ◽  
Han Population ◽  
Heavy Smokers

scholarly journals Clinical Characteristics of SARS-CoV-2 Pneumonia Compared to Controls in Chinese Han Population

2020 ◽  
Author(s):  
Yang Xu ◽  
Yi-rong Li ◽  
Qiang Zeng ◽  
Zhi-bing Lu ◽  
Yong-zhe Li ◽  
...  
Keyword(s):  
Mechanical Ventilation ◽  
Clinical Characteristics ◽  
Invasive Mechanical Ventilation ◽  
Case Series ◽  
Hospitalized Patients ◽  
Chinese Han Population ◽  
Common Symptom ◽  
Chinese Han ◽  
Han Population ◽  
Normal Controls

AbstractBackgroundIn December 2019, novel coronavirus (SARS-CoV-2) infected pneumonia occurred in Wuhan, China. The number of cases has increased rapidly but information on the clinical characteristics of SARS-CoV-2 pneumonia without comorbidities compared to normal controls in Chinese Han population is limited. Our objective is to describe the epidemiological and clinical characteristics of SARS-CoV-2 pneumonia without comorbidities compared to normal controls in the Chinese Han population.MethodsRetrospective, multi-center case series of the 69 consecutive hospitalized patients with confirmed SARS-CoV-2 pneumonia, from February 7 to February 28, 2020; final date of follow-up was February 29, 2020.ResultsThe study population included 69 hospitalized patients with confirmed SARS-CoV-2 pneumonia without comorbidities and 14,117 normal controls. 50.7% patients were male and 49.3% were female; 1.5% patients were asymptomatic cases, 63.8% patients were mild cases, and 36.2% patients were severe or critical cases. Compared with mild patients (n=44), severe or critical patients (n=25) were significantly older (median age, 67 years [IQR, 58-79] vs. 49 years [IQR, 36-60]; p<0.01). Fever was present in 98.6% of the patients. The second most common symptom was cough (62.3%), fatigue (58.0%), sputum (39.1%), and headache (33.3%). The median incubation period was 4 days (IQR, 2 to 7). Leukocyte count was 74.1% of normal controls and lymphocyte count was 45.9% of normal controls. The phenomenon of lymphocyte depletion (PLD) observed in severe or critical cases in 100%. Levels of lactate dehydrogenase, D-dimer, procalcitonin, and interleukin-6 were showed significant differences between mild and severe or critical cases. Chest computed tomographic scans showed bilateral patchy patterns (49.3%), local patchy shadowing (29.0%), and ground glass opacity (21.7%). 7.3% patients were diagnosed ARDS, 7.3% patients were diagnosed acute cardiac injury (troponin I >28 pg/mL) and 4.4% patients were diagnosed fungal infections or shock. 4.3% patients have been discharged; 1.5% patient had died; 1.5% patient had recovery.ConclusionsIn this multicenter case series of 69 patients without comorbidities, the full spectrum of asymptomatic, mild, severe, and critical cases is described. 50.7% patients were male and 49.3% were female; 1.5% patients were asymptomatic cases, 63.8% patients were mild cases, and 36.2% patients were severe or critical cases. 4.3% patients have been discharged; 1.5% patient had died; 1.5% patient had recovery. Among the 25 patients with severe or critical disease, 12.0% patients were underwent non-invasive mechanical ventilation, 8.0% patients underwent invasive mechanical ventilation, and 4.0% patients died.

scholarly journals The Association between NOS3 Gene Polymorphisms and Hypoxic-Ischemic Encephalopathy Susceptibility and Symptoms in Chinese Han Population

2016 ◽  
Vol 2016 ◽  
pp. 1-7 ◽  
Author(s):  
Yongqin Wu ◽  
Zhiling Zhu ◽  
Xiaoxia Fang ◽  
Ling Yin ◽  
Yuxia Liu ◽  
...  
Keyword(s):  
Gene Polymorphisms ◽  
Clinical Characteristics ◽  
Chinese Han Population ◽  
Hypoxic Ischemic Encephalopathy ◽  
Genotype Distribution ◽  
Chinese Han ◽  
Apgar Scores ◽  
Han Population ◽  
Nos3 Gene ◽  
Ischemic Encephalopathy

Endothelial NOS (NOS3) has a potential role in the prevention of neuronal injury in hypoxic-ischemic encephalopathy (HIE). Thus, we aimed to explore the association between NOS3 gene polymorphisms and HIE susceptibility and symptoms in a Chinese Han population. Three single nucleotide polymorphisms (SNPs) in the NOS3 gene, rs1800783, rs1800779, and rs2070744, were detected in 226 children with HIE and 212 healthy children in a Chinese Han population. Apgar scores and magnetic resonance image scans were used to estimate the symptoms and brain damage. The association analyses were conducted by using SNPStats and SPSS 18.0 software. The genotype and allele distributions of rs1800779 and rs1799983 displayed no significant differences between the patients and the controls, while the rs2070744 allele distribution was significantly different (correctedP=0.009). For clinical characteristics, the rs2070744 genotype distribution was significantly different in patients with different Apgar scores (≤5, TT/TC/CC = 6/7/5; 6~7, TT/TC/CC = 17/0/0; 8~9, TT/TC/CC = 6/2/0; 10, TT/TC/CC = 7/1/0; correctedP=0.006) in the 1001 to 1449 g birth weight subgroup. The haplotype test did not show any associations with the risk and clinical characteristics of HIE. The results suggest that NOS3 gene SNP rs2070744 was significantly associated with HIE susceptibility and symptom expression in Chinese Han population.

scholarly journals Impact of diabetes-related gene polymorphisms on the clinical characteristics of type 2 diabetes Chinese Han population

Oncotarget ◽  
2016 ◽  
Vol 7 (51) ◽  
pp. 85464-85471 ◽  
Author(s):  
Jing Li ◽  
Jiachen Wei ◽  
Pengcheng Xu ◽  
Mengdan Yan ◽  
Jingjie Li ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Gene Polymorphisms ◽  
Clinical Characteristics ◽  
Chinese Han Population ◽  
Related Gene ◽  
Chinese Han ◽  
Han Population
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