scholarly journals Antidopaminergic medication in healthy subjects provokes subjective and objective mental impairments tightly correlated with perturbation of biogenic monoamine metabolism and prolactin secretion

2018 ◽  
Vol Volume 14 ◽  
pp. 1125-1138
Author(s):  
Tanja Veselinovic ◽  
Ingo Vernaleken ◽  
Paul Cumming ◽  
Uwe Henning ◽  
Lina Winkler ◽  
...  
Keyword(s):  
Healthy Subjects ◽  
Prolactin Secretion ◽  
Monoamine Metabolism ◽  
Biogenic Monoamine

Coitus-induced orgasm stimulates prolactin secretion in healthy subjects

2001 ◽  
Vol 26 (3) ◽  
pp. 287-294 ◽  
Author(s):  
Michael S. Exton ◽  
Tillmann H.C. Krüger ◽  
Markus Koch ◽  
Erika Paulson ◽  
Wolfram Knapp ◽  
...  
Keyword(s):  
Healthy Subjects ◽  
Prolactin Secretion

Changes in the Dopaminergic Control of Prolactin Secretion and in Ovarian Steroids in Migraine

Cephalalgia ◽  
1986 ◽  
Vol 6 (1) ◽  
pp. 43-49 ◽  
Author(s):  
Giovanni Murialdo ◽  
Emilia Martignoni ◽  
Andrea De Maria ◽  
Maria Luisa Bonura ◽  
Grazia Sances ◽  
...  
Keyword(s):  
Luteal Phase ◽  
Healthy Subjects ◽  
Inhibitory Effect ◽  
Prolactin Secretion ◽  
Follicular Phase ◽  
Ovarian Steroids ◽  
Da Receptors ◽  
Dopaminergic Supersensitivity ◽  
Responses To Dopamine ◽  
Dopaminergic Control

Prolactin (PRL) responses to dopamine (DA) blockers and to direct and indirect DA agonists have been studied in 23 healthy women, 17 women with catamenial migraine and 17 with non-catamenial migraine in both their follicular and luteal phases. PRL responses to the DA blockers were greater in the follicular phase of both migraine groups than in controls. The inhibitory effect of nomifensine on PRL secretion was dampened in the follicular phase of both migraine groups. These findings demonstrate an increased PRL reserve in migraine and suggest the existence of a dopaminergic supersensitivity of the lactotrophic postsynaptic DA receptors. The impaired inhibitory effect of nomifensine on PRL secretion hints at a decrease of the presynaptic DA content in tuberoinfundibular DA neurons. In migrainous women 17-β-oestradiol levels are higher in both ovarian phases, whereas progesterone concentrations and the progesterone to oestradiol ratio are lower than in healthy subjects in the luteal phase. These data suggest the existence of a change in the oestrogen-dependent modulation of pituitary DA receptors.

Reflex Responses in Upper Limb Muscles to Cutaneous Stimuli

1993 ◽  
Vol 20 (04) ◽  
pp. 271-278 ◽  
Author(s):  
R. Chen
Keyword(s):  
Stimulus Intensity ◽  
Upper Limb ◽  
Healthy Subjects ◽  
Voluntary Contraction ◽  
Cutaneous Reflexes ◽  
Focal Lesions ◽  
Normal Ranges ◽  
Conduction Velocities ◽  
Limb Muscles ◽  
Biphasic Responses

ABSTRACT:Cutaneous reflexes in the upper limb were elicited by stimulating digital nerves and recorded by averaging rectified EMG from proximal and distal upper limb muscles during voluntary contraction. Distal muscles often showed a triphasic response: an inhibition with onset about 50 ms (Il) followed by a facilitation with onset about 60 ms (E2) followed by another inhibition with onset about 80 ms (12). Proximal muscles generally showed biphasic responses beginning with facilitation or inhibition with onset at about 40 ms. Normal ranges for the amplitude of these components were established from recordings on 22 arms of 11 healthy subjects. An attempt was made to determine the alterent fibers responsible for the various components by varying the stimulus intensity, by causing ischemic block of larger fibers and by estimating the afferent conduction velocities. The central pathways mediating these reflexes were examined by estimating central delays and by studying patients with focal lesions

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