Levels of chlorpromazine and its active metabolites in rat brain and the relationship to central monoamine metabolism and prolactin secretion

1977 ◽  
Vol 53 (1) ◽  
pp. 13-18 ◽  
Author(s):  
Gunnel Alfredsson ◽  
Frits-Axel Wiesel ◽  
Paul Skett
Keyword(s):  
Rat Brain ◽  
Prolactin Secretion ◽  
Active Metabolites ◽  
Monoamine Metabolism ◽  
Central Monoamine ◽  
The Relationship

Measurement of hydraulic conductivity in isolated arterioles of rat brain cortex

1993 ◽  
Vol 264 (6) ◽  
pp. H1788-H1797 ◽  
Author(s):  
M. Kimura ◽  
H. H. Dietrich ◽  
V. H. Huxley ◽  
D. R. Reichner ◽  
R. G. Dacey
Keyword(s):  
Hydraulic Conductivity ◽  
Rat Brain ◽  
Room Temperature ◽  
Applied Pressure ◽  
Unit Surface Area ◽  
Ph Change ◽  
Brain Vessels ◽  
Spontaneous Tone ◽  
Cerebral Arterioles ◽  
The Relationship

We have developed a new method for quantification of arteriolar hydraulic conductivity (Lp) from isolated rat brain vessels. The volume flux of water per unit surface area across the arteriole wall (Jv/S) was assessed from measurements of silicon oil drop movement within an occluded vessel at two to three pressures (between 20 and 70 mmHg); the Lp was derived from the slope of the relationship between Jv/S and applied pressure. Lp was measured in isolated cerebral arterioles 1) at room temperature (22 degrees C) without spontaneous vessel tone (control Lp; n = 11), 2) at room temperature with 10(-4) M adenosine (n = 5), and 3) at 37 degrees C with vessels dilated submaximally with 10(-4) M adenosine (n = 6). Lp at 22 degrees C without adenosine was 13.2 +/- 4.2 x 10(-9) (+/- SE) cm.s-1.cmH2O-1 for all vessels studied. Lp values ranged from 1.2 to 44.1 x 10(-9) cm.s-1.cmH2O-1 with a median value that was 5.9 x 10(-9) cm.s-1.cmH2O-1. Lp increased significantly (on average, 2.6-fold) with adenosine at 37 degrees C but not with adenosine at 22 degrees C. Control Lp bore no relationship to either the development of spontaneous tone or the diameter response to pH change, two recognized indicators of vessel viability.

scholarly journals Detection of active proteasome structures in brain extracts: proteasome features of August rat brain with violations in monoamine metabolism

Oncotarget ◽  
2017 ◽  
Vol 8 (41) ◽  
pp. 70941-70957 ◽  
Author(s):  
Pavel A. Erokhov ◽  
Yulia V. Lyupina ◽  
Alexandra S. Radchenko ◽  
Anna A. Kolacheva ◽  
Yulia O. Nikishina ◽  
...  
Keyword(s):  
Rat Brain ◽  
Monoamine Metabolism ◽  
Brain Extracts

scholarly journals EFFECT OF ANOXIA ON STRIATAL MONOAMINE METABOLISM IN IMMATURE RAT BRAIN COMPARED WITH THAT OF HYPOXIA : AN IN VIVO MICRODIALYSIS STUDY† 1378

1996 ◽  
Vol 39 ◽  
pp. 232-232
Author(s):  
Wako Nakajima ◽  
Akira Ishida ◽  
Hirokazu Arai ◽  
Yasushi Takahashi ◽  
Tadahiko Ito ◽  
...  
Keyword(s):  
Rat Brain ◽  
In Vivo Microdialysis ◽  
Monoamine Metabolism ◽  
Immature Rat ◽  
Microdialysis Study

Evidence for a link between tail biting and central monoamine metabolism in pigs (Sus scrofa domestica)

2015 ◽  
Vol 143 ◽  
pp. 151-157 ◽  
Author(s):  
Anna Valros ◽  
Pälvi Palander ◽  
Mari Heinonen ◽  
Camilla Munsterhjelm ◽  
Emma Brunberg ◽  
...  
Keyword(s):  
Sus Scrofa ◽  
Monoamine Metabolism ◽  
Tail Biting ◽  
Central Monoamine ◽  
Sus Scrofa Domestica

Monoamine Metabolism in the Isolated Perfused Rat Brain

1976 ◽  
Vol 4 (1) ◽  
pp. 22-26 ◽  
Author(s):  
H. F. WOODS ◽  
A. R. GREEN ◽  
M. B. H. YOUDIM ◽  
D. G. GRAHAME-SMITH
Keyword(s):  
Rat Brain ◽  
Monoamine Metabolism ◽  
Isolated Perfused Rat Brain

Monitoring plasma concentrations of psychotropic drugs

1974 ◽  
Vol 12 (2) ◽  
pp. 6-8
Keyword(s):  
Steady State ◽  
Plasma Concentration ◽  
Tissue Concentration ◽  
Plasma Concentrations ◽  
Water Concentration ◽  
Plasma Samples ◽  
Active Metabolites ◽  
The Relationship ◽  
The Brain ◽  
Reliable Methods

Techniques are now available for estimating the plasma concentration of several drugs used in psychiatry. These techniques are clearly important for research but they can hardly be expected to improve the clinical management of patients unless the estimation is sensitive, reliable and reasonably quick; the method should be specific for the particular drug but should also specifically estimate any active metabolites. Even when reliable figures have been obtained, much more information is needed before they can be interpreted. The relationship between plasma (or plasma water) concentration and relevant tissue concentration (e. g. in the brain) must be known. Plasma samples should be taken at appropriate times, e. g. after the attainment of ‘steady-state’ conditions: plasma and tissue levels will then be in equilibrium. Diagnoses must be soundly based if inferences are to be drawn. Reliable methods of assessing clinical response must be available. These requirements pose difficult problems in psychiatry.

Effects of rolipram, a novel antidepressant, on monoamine metabolism in rat brain

1985 ◽  
Vol 63 (1) ◽  
pp. 1-12 ◽  
Author(s):  
W. Kehr ◽  
Gerlinde Debus ◽  
Ruth Neumeister
Keyword(s):  
Rat Brain ◽  
Monoamine Metabolism

Developmental changes in rat brain monoamine metabolism and β-adrenoceptor subtypes after chronic prenatal exposure to propranolol

1993 ◽  
Vol 22 (6) ◽  
pp. 589-598 ◽  
Author(s):  
Erna B.H.W. Erdtsieck-Ernste ◽  
Matthijs G.P. Feenstra ◽  
Margriet H.A. Botterblom ◽  
Gerard J. Boer
Keyword(s):  
Rat Brain ◽  
Prenatal Exposure ◽  
Developmental Changes ◽  
Monoamine Metabolism ◽  
Brain Monoamine
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