scholarly journals In vivo experimental study on bone regeneration in critical bone defects using PIB nanogels/boron-containing mesoporous bioactive glass composite scaffold

2015 ◽  
pp. 839 ◽  
Author(s):  
Yufeng Zhang ◽  
Xiaohui Chen ◽  
Richard Miron ◽  
Yanbing Zhao ◽  
Qiao Zhang ◽  
...  
Keyword(s):  
Experimental Study ◽  
Bioactive Glass ◽  
Bone Regeneration ◽  
Composite Scaffold ◽  
Bone Defects ◽  
Glass Composite ◽  
Critical Bone Defects ◽  
Mesoporous Bioactive Glass

In vivo experimental study on bone regeneration in critical bone defects using an injectable biodegradable PLA/PGA copolymer

2005 ◽  
Vol 99 (2) ◽  
pp. 148-154 ◽  
Author(s):  
Lia Rimondini ◽  
Nicolò Nicoli-Aldini ◽  
Milena Fini ◽  
Gaetano Guzzardella ◽  
Matilde Tschon ◽  
...  
Keyword(s):  
Experimental Study ◽  
Bone Regeneration ◽  
Bone Defects ◽  
Critical Bone Defects

3D printing Cu-doped bioactive glass composite scaffold promote bone regeneration through activating HIF-1α and TNF-α pathway of hUVECs

2021 ◽  
Author(s):  
Qiyuan Dai ◽  
Qingtao Li ◽  
Huichang Gao ◽  
Longtao Yao ◽  
Zefeng Lin ◽  
...  
Keyword(s):  
3D Printing ◽  
Bioactive Glass ◽  
Bone Regeneration ◽  
Structural Component ◽  
Composite Scaffold ◽  
Glass Composite ◽  
Cellular Processes ◽  
Tnf Α

The increasing insight of molecular and cellular processes within angiogenic cascade enhances the survival and integration of engineered bone constructs. Cu-doped bioactive glass (Cu-BG) now is a potential structural component...

Potential of growth factor incorporated mesoporous bioactive glass for in vivo bone regeneration

2019 ◽  
Vol 91 ◽  
pp. 182-192 ◽  
Author(s):  
V. Lalzawmliana ◽  
Akrity Anand ◽  
Vinod Kumar ◽  
Piyali Das ◽  
K. Bavya Devi ◽  
...  
Keyword(s):  
Growth Factor ◽  
Bioactive Glass ◽  
Bone Regeneration ◽  
Mesoporous Bioactive Glass

Effect of soft laser and bioactive glass on bone regeneration in the treatment of bone defects (an experimental study)

2008 ◽  
Vol 24 (4) ◽  
pp. 527-533 ◽  
Author(s):  
Nayer S. AboElsaad ◽  
Mena Soory ◽  
Laila M. A. Gadalla ◽  
Laila I. Ragab ◽  
Stephen Dunne ◽  
...  
Keyword(s):  
Experimental Study ◽  
Bioactive Glass ◽  
Bone Regeneration ◽  
Bone Defects

Strontium folate loaded biohybrid scaffolds seeded with dental pulp stem cells induce in vivo bone regeneration in critical sized defects

2016 ◽  
Vol 4 (11) ◽  
pp. 1596-1604 ◽  
Author(s):  
Marcela Martin-del-Campo ◽  
Raul Rosales-Ibañez ◽  
Keila Alvarado ◽  
Jose G. Sampedro ◽  
Christian A. Garcia-Sepulveda ◽  
...  
Keyword(s):  
Stem Cells ◽  
Bone Regeneration ◽  
Dental Pulp ◽  
Bone Defects ◽  
Dental Pulp Stem Cells ◽  
Critical Bone Defects ◽  
Complete Regeneration

Strontium folate loaded biohybrid scaffolds enhance dental pulp stem cells replication and differentiation, promoting complete regeneration of critical bone defects.

Strontium-incorporated mesoporous bioactive glass scaffolds stimulating in vitro proliferation and differentiation of bone marrow stromal cells and in vivo regeneration of osteoporotic bone defects

2013 ◽  
Vol 1 (41) ◽  
pp. 5711-5722 ◽  
Author(s):  
Yufeng Zhang ◽  
Lingfei Wei ◽  
Jiang Chang ◽  
Richard J. Miron ◽  
Bin Shi ◽  
...  
Keyword(s):  
Bioactive Glass ◽  
Stromal Cells ◽  
Bone Marrow Stromal Cells ◽  
Bone Defects ◽  
Osteoporotic Bone ◽  
In Vitro Proliferation ◽  
Proliferation And Differentiation ◽  
Mesoporous Bioactive Glass

Sr-containing mesoporous bioactive glass scaffolds significantly enhanced the regeneration of osteoporotic bone defects.

scholarly journals In Vivo Investigation of Polymer-Ceramic PCL/HA and PCL/β-TCP 3D Composite Scaffolds and Electrical Stimulation for Bone Regeneration

Polymers ◽  
2021 ◽  
Vol 14 (1) ◽  
pp. 65
Author(s):  
Júlia Venturini Helaehil ◽  
Carina Basqueira Lourenço ◽  
Boyang Huang ◽  
Luiza Venturini Helaehil ◽  
Isaque Xavier de Camargo ◽  
...  
Keyword(s):  
Gene Expression ◽  
Electrical Stimulation ◽  
Bone Regeneration ◽  
Bone Defects ◽  
Composite Scaffolds ◽  
Electrical Therapy ◽  
Biological Recognition ◽  
3D Composite ◽  
Critical Bone Defects

Critical bone defects are a major clinical challenge in reconstructive bone surgery. Polycaprolactone (PCL) mixed with bioceramics, such as hydroxyapatite (HA) and tricalcium phosphate (TCP), create composite scaffolds with improved biological recognition and bioactivity. Electrical stimulation (ES) aims to compensate the compromised endogenous electrical signals and to stimulate cell proliferation and differentiation. We investigated the effects of composite scaffolds (PCL with HA; and PCL with β-TCP) and the use of ES on critical bone defects in Wistar rats using eight experimental groups: untreated, ES, PCL, PCL/ES, HA, HA/ES, TCP, and TCP/ES. The investigation was based on histomorphometry, immunohistochemistry, and gene expression analysis. The vascular area was greater in the HA/ES group on days 30 and 60. Tissue mineralization was greater in the HA, HA/ES, and TCP groups at day 30, and TCP/ES at day 60. Bmp-2 gene expression was higher in the HA, TCP, and TCP/ES groups at day 30, and in the TCP/ES and PCL/ES groups at day 60. Runx-2, Osterix, and Osteopontin gene expression were also higher in the TCP/ES group at day 60. These results suggest that scaffolds printed with PCL and TCP, when paired with electrical therapy application, improve bone regeneration.

scholarly journals Incorporation of Zinc into Binary SiO2-CaO Mesoporous Bioactive Glass Nanoparticles Enhances Anti-Inflammatory and Osteogenic Activities

Pharmaceutics ◽  
2021 ◽  
Vol 13 (12) ◽  
pp. 2124
Author(s):  
Haishui Sun ◽  
Kai Zheng ◽  
Tian Zhou ◽  
Aldo R. Boccaccini
Keyword(s):  
Bioactive Glass ◽  
Bone Regeneration ◽  
Cellular Response ◽  
Culture Medium ◽  
Inflammatory Responses ◽  
Bone Defects ◽  
Bone Tissue Regeneration ◽  
Ifn Γ ◽  
Anti Inflammatory ◽  
Mesoporous Bioactive Glass

During the healing and repair of bone defects, uncontrolled inflammatory responses can compromise bone regeneration. Biomaterials with anti-inflammatory activity are favorable for bone tissue regeneration processes. In this work, multifunctional Zn-containing mesoporous bioactive glass nanoparticles (Zn-MBGs) exhibiting favorable osteogenic and anti-inflammatory activities were produced employing a sol-gel method. Zn-MBGs exhibited a mesoporous spherical shape and nanoscale particle size (100 ± 20 nm). They were degradable in cell culture medium, and could release Si, Ca, and Zn in a sustained manner. Zn-MBGs also exhibited a concentration-dependent cellular response. The extract of Zn-MBGs obtained by incubation at 0.1 mg/mL (in culture medium) for 24 h could enhance in vitro mineralization, alkaline phosphatase activity, the expression of osteogenesis-related genes, and the production of intracellular protein osteocalcin of rat bone marrow stromal cells (BMSCs). Moreover, the extract of Zn-MBGs at 0.1 mg/mL could significantly downregulate the expression of inflammatory genes and the production of inducible nitric oxide in RAW 264.7 cells, particularly under stimulation of inflammatory signals interferon-γ (IFN-γ) and lipopolysaccharide (LPS). Zn-MBGs also inhibited the pro-inflammatory M1 polarization of RAW264.7 cells induced by LPS and IFN-γ. In summary, we successfully synthesized Zn-MBGs with concentration-dependent osteogenic and anti-inflammatory activities. Zn-MBGs show their great potential in immunomodulation strategies for bone regeneration, representing a multifunctional biomaterial that can be applied to regenerate bone defects under inflammatory conditions.

Mesoporous bioactive glass scaffold delivers salvianolic acid B to promote bone regeneration in a rat cranial defect model

2020 ◽  
Vol 17 ◽  
Author(s):  
Lin Wu ◽  
Zhanying Wei ◽  
Siyu He ◽  
Yunlong Bi ◽  
Yang Cao ◽  
...  
Keyword(s):  
Bioactive Glass ◽  
Bone Regeneration ◽  
Osteogenic Differentiation ◽  
Bone Defects ◽  
Salvianolic Acid B ◽  
Fluorescence Labeling ◽  
High Dose ◽  
Alizarin Red ◽  
Salvianolic Acid ◽  
Mesoporous Bioactive Glass

Background: Mesoporous bioactive glass (MBG) has been widely studied because of its excellent histocompatibility and degradability. However, due to the lack of good osteoinductive activity, the pure MBG scaffold is not effective in repairing large-scale bone defects. Objective: To observe the repair effect of MBG scaffolds delivering salvianolic acid B (SB) on critical bone defects in rats. Method: In this study, MBG scaffolds were used as delivery vehicle. SB, a small molecular active drug with good osteogenic differentiation ability, was loaded into the MBG scaffolds at low, medium and high doses. The effect of SB released from the MBG scaffolds on osteogenic differentiation of rat bone marrow mesenchymal stem cells (rBMSCs) was investigated using alkaline phosphatase staining, alizarin red staining and real-time quantitative polymerase chain reaction. Moreover, 8 weeks after implantation of the scaffolds, the bone regeneration was evaluated by micro-CT, sequential fluorescence labeling and histological staining analysis. Results: The in vitro results showed that different doses of SB had similar release rate from scaffolds and could be released from scaffolds continuously. The middle dose (MBG/MSB) and high dose (MBG/HSB) groups significantly promoted the osteogenic differentiation of rBMSCs when compared with low dose (MBG/LSB) group. Moreover, SB produced significant increases in newly formed bone of calvarial bone defects in rats. Conclusion: It’s concluded that the use of MBG scffolds delivering SB is an effective strategy for the treatment of bone defects.

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