scholarly journals Three dimensional printing of calcium sulfate and mesoporous bioactive glass scaffolds for improving bone regeneration in vitro and in vivo

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Xin Qi ◽  
Peng Pei ◽  
Min Zhu ◽  
Xiaoyu Du ◽  
Chen Xin ◽  
...  
Keyword(s):  
Bioactive Glass ◽  
Bone Regeneration ◽  
Calcium Sulfate ◽  
Three Dimensional ◽  
Three Dimensional Printing ◽  
Regeneration In Vitro ◽  
Dimensional Printing ◽  
Mesoporous Bioactive Glass

Three-dimensional printing of strontium-containing mesoporous bioactive glass scaffolds for bone regeneration

2014 ◽  
Vol 10 (5) ◽  
pp. 2269-2281 ◽  
Author(s):  
Jianhua Zhang ◽  
Shichang Zhao ◽  
Yufang Zhu ◽  
Yinjun Huang ◽  
Min Zhu ◽  
...  
Keyword(s):  
Bioactive Glass ◽  
Bone Regeneration ◽  
Three Dimensional ◽  
Three Dimensional Printing ◽  
Dimensional Printing ◽  
Mesoporous Bioactive Glass

scholarly journals Biocompatibility of Bespoke 3D-Printed Titanium Alloy Plates for Treating Acetabular Fractures

2018 ◽  
Vol 2018 ◽  
pp. 1-12 ◽  
Author(s):  
Xuezhi Lin ◽  
Xingling Xiao ◽  
Yimeng Wang ◽  
Cheng Gu ◽  
Canbin Wang ◽  
...  
Keyword(s):  
Titanium Alloy ◽  
Culture Medium ◽  
Three Dimensional ◽  
Acetabular Fractures ◽  
Three Dimensional Printing ◽  
3D Printed ◽  
Manufacturing Techniques ◽  
Dimensional Printing

Treatment of acetabular fractures is challenging, not only because of its complicated anatomy but also because of the lack of fitting plates. Personalized titanium alloy plates can be fabricated by selective laser melting (SLM) but the biocompatibility of these three-dimensional printing (3D-printed) plates remains unknown. Plates were manufactured by SLM and their cytocompatibility was assessed by observing the metabolism of L929 fibroblasts incubated with culture medium extracts using a CCK-8 assay and their morphology by light microscopy. Allergenicity was tested using a guinea pig maximization test. In addition, acute systemic toxicity of the 3D-printed plates was determined by injecting extracts from the implants into the tail veins of mice. Finally, the histocompatibility of the plates was investigated by implanting them into the dorsal muscles of rabbits. The in vitro results suggested that cytocompatibility of the 3D-printed plates was similar to that of conventional plates. The in vivo data also demonstrated histocompatibility that was comparable between the two manufacturing techniques. In conclusion, both in vivo and in vitro experiments suggested favorable biocompatibility of 3D-printed titanium alloy plates, indicating that it is a promising option for treatment of acetabular fractures.

Injectable chitosan/gelatin/bioactive glass nanocomposite hydrogels for potential bone regeneration: In vitro and in vivo analyses

2019 ◽  
Vol 132 ◽  
pp. 811-821 ◽  
Author(s):  
Cheisy D.F. Moreira ◽  
Sandhra M. Carvalho ◽  
Rodrigo M. Florentino ◽  
Andressa França ◽  
Bárbara S. Okano ◽  
...  
Keyword(s):  
Bioactive Glass ◽  
Bone Regeneration ◽  
Nanocomposite Hydrogels ◽  
Regeneration In Vitro

scholarly journals Development of 3D-Printed, Liquisolid and Directly Compressed Glimepiride Tablets, Loaded with Black Seed Oil Self-Nanoemulsifying Drug Delivery System: In Vitro and In Vivo Characterization

2022 ◽  
Vol 15 (1) ◽  
pp. 68
Author(s):  
Tarek A. Ahmed ◽  
Hanadi A. Alotaibi ◽  
Waleed S. Alharbi ◽  
Martin K. Safo ◽  
Khalid M. El-Say
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Seed Oil ◽  
Three Dimensional ◽  
Three Dimensional Printing ◽  
Black Seed Oil ◽  
Compression Characteristics ◽  
Dimensional Printing

Glimepiride is characterized by an inconsistent dissolution and absorption profile due to its limited aqueous solubility. The aim of this study was to develop glimepiride tablets using three different manufacturing techniques, as well as to study their quality attributes and pharmacokinetics behavior. Black seed oil based self-nanoemulsifying drug delivery system (SNEDDS) formulation was developed and characterized. Glimepiride liquisolid and directly compressed tablets were prepared and their pre-compression and post-compression characteristics were evaluated. Semi-solid pastes loaded with SNEDDS were prepared and used to develop three-dimensional printing tablets utilizing the extrusion technique. In vivo comparative pharmacokinetics study was conducted on Male Wistar rats using a single dose one-period parallel design. The developed SNEDDS formulation showed a particle size of 45.607 ± 4.404 nm, and a glimepiride solubility of 25.002 ± 0.273 mg/mL. All the studied tablet formulations showed acceptable pre-compression and post-compression characteristics and a difference in their in vitro drug release behavior. The surface of the liquisolid and directly compressed tablets was smooth and non-porous, while the three-dimensional printing tablets showed a few porous surfaces. The inner structure of the liquisolid tablets showed some cracks and voids between the incorporated tablet ingredients while that of the three-dimensional printing tablets displayed some tortuosity and a gel porous-like structure. Most of the computed pharmacokinetic parameters improved with the liquisolid and three-dimensional printed tablets. The relative bioavailabilities of the three-dimensional printed and liquisolid tablets compared to commercial product were 121.68% and 113.86%, respectively. Therefore, the liquisolid and three-dimensional printed tablets are promising techniques for modifying glimepiride release and improving in vivo performance but more clinical investigations are required.

Three-dimensional printing of tricalcium silicate/mesoporous bioactive glass cement scaffolds for bone regeneration

2016 ◽  
Vol 4 (46) ◽  
pp. 7452-7463 ◽  
Author(s):  
Peng Pei ◽  
Xin Qi ◽  
Xiaoyu Du ◽  
Min Zhu ◽  
Shichang Zhao ◽  
...  
Keyword(s):  
3D Printing ◽  
Bioactive Glass ◽  
Biological Property ◽  
Three Dimensional ◽  
Tricalcium Silicate ◽  
Curing Process ◽  
Three Dimensional Printing ◽  
First Time ◽  
Dimensional Printing ◽  
Mesoporous Bioactive Glass

Tricalcium silicate/mesoporous bioactive glass (C3S/MBG) cement scaffolds were successfully fabricated for the first time by 3D printing with a curing process, which combined the hydraulicity of C3S with the excellent biological property of MBG together.

scholarly journals Three-Dimensional Zirconia-Based Scaffolds for Load-Bearing Bone-Regeneration Applications: Prospects and Challenges

Materials ◽  
2021 ◽  
Vol 14 (12) ◽  
pp. 3207
Author(s):  
Kumaresan Sakthiabirami ◽  
Vaiyapuri Soundharrajan ◽  
Jin-Ho Kang ◽  
Yunzhi Peter Yang ◽  
Sang-Won Park
Keyword(s):  
Bone Regeneration ◽  
Biological Activities ◽  
Three Dimensional ◽  
In Vivo Studies ◽  
High Mechanical Strength ◽  
Real World Applications ◽  
3D Fabrication ◽  
Dental Applications

The design of zirconia-based scaffolds using conventional techniques for bone-regeneration applications has been studied extensively. Similar to dental applications, the use of three-dimensional (3D) zirconia-based ceramics for bone tissue engineering (BTE) has recently attracted considerable attention because of their high mechanical strength and biocompatibility. However, techniques to fabricate zirconia-based scaffolds for bone regeneration are in a stage of infancy. Hence, the biological activities of zirconia-based ceramics for bone-regeneration applications have not been fully investigated, in contrast to the well-established calcium phosphate-based ceramics for bone-regeneration applications. This paper outlines recent research developments and challenges concerning numerous three-dimensional (3D) zirconia-based scaffolds and reviews the associated fundamental fabrication techniques, key 3D fabrication developments and practical encounters to identify the optimal 3D fabrication technique for obtaining 3D zirconia-based scaffolds suitable for real-world applications. This review mainly summarized the articles that focused on in vitro and in vivo studies along with the fundamental mechanical characterizations on the 3D zirconia-based scaffolds.

scholarly journals In Vitro and In Vivo Evaluation of a Three-Dimensional Porous Multi-Walled Carbon Nanotube Scaffold for Bone Regeneration

Nanomaterials ◽  
2017 ◽  
Vol 7 (2) ◽  
pp. 46 ◽  
Author(s):  
Manabu Tanaka ◽  
Yoshinori Sato ◽  
Mei Zhang ◽  
Hisao Haniu ◽  
Masanori Okamoto ◽  
...  
Keyword(s):  
Carbon Nanotube ◽  
Bone Regeneration ◽  
Three Dimensional ◽  
In Vivo Evaluation ◽  
Multi Walled Carbon Nanotube
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