scholarly journals High gene delivery efficiency of alkylated low-molecular-weight polyethylenimine through gemini surfactant-like effect

2014 ◽  
pp. 3567 ◽  
Author(s):  
Shan Liu ◽  
Wei Huang ◽  
Ming-Ji Jin ◽  
Qi-Ming Wang ◽  
Gan-Lin Zhang ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Gene Delivery ◽  
Gemini Surfactant ◽  
Low Molecular Weight ◽  
High Gene ◽  
Delivery Efficiency

scholarly journals FGF Receptor-Mediated Gene Delivery Using Ligands Coupled to PEI-β-CyD

2012 ◽  
Vol 2012 ◽  
pp. 1-7 ◽  
Author(s):  
Yiping Hu ◽  
Guping Tang ◽  
Jun Liu ◽  
Wenxiang Cheng ◽  
Ye Yue ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Gene Delivery ◽  
Human Cancer ◽  
Fibroblast Growth Factor Receptors ◽  
Fgf Receptor ◽  
Human Cancer Cells ◽  
High Gene ◽  
Targeting Ability ◽  
Delivery Efficiency

A novel vector with high gene delivery efficiency and special cell-targeting ability was developed using a good strategy that utilized low-molecular-weight polyethylenimine (PEI; molecular weight: 600 KDa [PEI600]) crosslinked toβ-cyclodextrin (β-CyD) via a facile synthetic route. Fibroblast growth factor receptors (FGFRs) are highly expressed in a variety of human cancer cells and are potential targets for cancer therapy. In this paper, CY11 peptides, which have been proven to combine especially with FGFRs on cell membranes were coupled to PEI-β-CyD usingN-succinimidyl-3-(2-pyridyldithio) propionate as a linker. The ratios of PEI600,β-CyD, and peptide were calculated based on proton integral values obtained from the1H-NMR spectra of the resulting products. Electron microscope observations showed that CY11-PEI-β-CyD can efficiently condense plasmid DNA (pDNA) into nanoparticles of about 200 nm, and MTT assays suggested the decreased toxicity of the polymer. Experiments on gene delivery efficiency in vitro showed that CY11-PEI-β-CyD/pDNA polyplexes had significantly greater transgene activities than PEI-β-CyD/pDNA in the COS-7 and HepG2 cells, which positively expressed FGFR, whereas no such effect was observed in the PC-3 cells, which negatively expressed FGFR. Our current research indicated that the synthesized nonviral vector shows improved gene delivery efficiency and targeting specificity in FGFR-positive cells.

Gene delivery with low molecular weight linear polyethylenimines

2005 ◽  
Vol 7 (10) ◽  
pp. 1287-1298 ◽  
Author(s):  
Miriam Breunig ◽  
Uta Lungwitz ◽  
Renate Liebl ◽  
Claudia Fontanari ◽  
Juergen Klar ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Gene Delivery ◽  
Low Molecular Weight

Co-liposomes of redox-active alkyl-ferrocene modified low MW branched PEI and DOPE for efficacious gene delivery in serum

2015 ◽  
Vol 3 (11) ◽  
pp. 2318-2330 ◽  
Author(s):  
Krishan Kumar ◽  
Gururaja Vulugundam ◽  
Paturu Kondaiah ◽  
Santanu Bhattacharya
Keyword(s):  
Molecular Weight ◽  
Gene Delivery ◽  
Low Molecular Weight ◽  
Redox Active ◽  
Branched Polyethylenimine

Ferrocenylated lipopolymers based on low molecular weight, branched polyethylenimine (BPEI 800 Da) for redox controlled gene delivery.

Polyelectrolyte Complexes of Low Molecular Weight PEI and Citric Acid as Efficient and Nontoxic Vectors for in Vitro and in Vivo Gene Delivery

2016 ◽  
Vol 27 (3) ◽  
pp. 549-561 ◽  
Author(s):  
M. Dolores Giron-Gonzalez ◽  
Rafael Salto-Gonzalez ◽  
F. Javier Lopez-Jaramillo ◽  
Alfonso Salinas-Castillo ◽  
Ana Belen Jodar-Reyes ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Citric Acid ◽  
Gene Delivery ◽  
Low Molecular Weight ◽  
Polyelectrolyte Complexes ◽  
In Vivo Gene Delivery

Zinc ion coordination significantly improved the transfection efficiency of low molecular weight polyethylenimine

2019 ◽  
Vol 7 (4) ◽  
pp. 1716-1728 ◽  
Author(s):  
Huapan Fang ◽  
Lin Lin ◽  
Jie Chen ◽  
Jiayan Wu ◽  
Huayu Tian ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Gene Delivery ◽  
Delivery System ◽  
Transfection Efficiency ◽  
Zinc Ion ◽  
Low Molecular Weight ◽  
Gene Delivery System ◽  
System P

A zinc ion coordination-contained polycationic gene delivery system.

Impact of Molecular Weight in Four-Branched Star Vectors with Narrow Molecular Weight Distribution on Gene Delivery Efficiency

2009 ◽  
Vol 20 (12) ◽  
pp. 2293-2299 ◽  
Author(s):  
Yasushi Nemoto ◽  
Alexey Borovkov ◽  
Yue-Min Zhou ◽  
Yoshiaki Takewa ◽  
Eisuke Tatsumi ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Gene Delivery ◽  
Molecular Weight Distribution ◽  
Weight Distribution ◽  
Narrow Molecular Weight Distribution ◽  
Delivery Efficiency

scholarly journals Low Molecular Weight pDMAEMA-block-pHEMA Block-Copolymers Synthesized via RAFT-Polymerization: Potential Non-Viral Gene Delivery Agents?

Polymers ◽  
2011 ◽  
Vol 3 (2) ◽  
pp. 693-718 ◽  
Author(s):  
Olga Samsonova ◽  
Christian Pfeiffer ◽  
Markus Hellmund ◽  
Olivia M. Merkel ◽  
Thomas Kissel
Keyword(s):  
Molecular Weight ◽  
Block Copolymers ◽  
Gene Delivery ◽  
Raft Polymerization ◽  
Viral Gene ◽  
Low Molecular Weight ◽  
Viral Gene Delivery

A novel nonviral gene delivery vector: Low-molecular-weight polyethylenimine-graft-ovalbumin

2009 ◽  
Vol 114 (6) ◽  
pp. 3744-3750 ◽  
Author(s):  
Dan Chen ◽  
Yang Liu ◽  
Anna Lehtinen ◽  
Qiying Jiang ◽  
Jun Liu ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Gene Delivery ◽  
Nonviral Gene Delivery ◽  
Low Molecular Weight ◽  
Gene Delivery Vector ◽  
Delivery Vector

Diol glycidyl ether-bridged low molecular weight PEI as potential gene delivery vehicles

2015 ◽  
Vol 3 (13) ◽  
pp. 2660-2670 ◽  
Author(s):  
Qian Guo ◽  
Yan-Hong Liu ◽  
Miao-Miao Xun ◽  
Ji Zhang ◽  
Zheng Huang ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Gene Delivery ◽  
Ring Opening ◽  
Transfection Efficiency ◽  
Glycidyl Ether ◽  
Ring Opening Polymerization ◽  
Low Molecular Weight ◽  
Delivery Vehicles ◽  
Gene Delivery Vehicles

PEI 600-based polymers were synthesized via ring-opening polymerization and exhibited much better transfection efficiency and biocompatibility than PEI 25 kDa.

Low Molecular Weight Polyethylenimine-graft-Tween 85 for Effective Gene Delivery: Synthesis and in Vitro Characteristics

2012 ◽  
Vol 23 (2) ◽  
pp. 222-231 ◽  
Author(s):  
Jisheng Xiao ◽  
Xiaopin Duan ◽  
Qi Yin ◽  
Lingli Chen ◽  
Zhiwen Zhang ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Gene Delivery ◽  
Low Molecular Weight
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