scholarly journals The antitumor activity of a doxorubicin loaded, iRGD-modified sterically-stabilized liposome on B16-F10 melanoma cells: in vitro and in vivo evaluation

2013 ◽  
pp. 2473 ◽  
Author(s):  
Xuan Zhang ◽  
Yu ◽  
Wei-Qiang Zhang ◽  
Li-Min Luo ◽  
Song ◽  
...  
Keyword(s):  
Antitumor Activity ◽  
Melanoma Cells ◽  
In Vivo Evaluation

In vitro and in vivo Enhancement of Vincristine Antitumor Activity on B16 Melanoma Cells by Calcium Antagonist Flunarizine

Oncology ◽  
1987 ◽  
Vol 44 (1) ◽  
pp. 17-23 ◽  
Author(s):  
Alberto Bellelli ◽  
Claudia Camboni ◽  
Giovanna de Luca ◽  
Mario Materazzi ◽  
Manlio Mattioni ◽  
...  
Keyword(s):  
Calcium Antagonist ◽  
Antitumor Activity ◽  
Melanoma Cells ◽  
B16 Melanoma ◽  
B16 Melanoma Cells

scholarly journals Enhanced Antitumor Activity of Monophosphate Ester Prodrugs of Gemcitabine: In Vitro and In Vivo Evaluation

2016 ◽  
Vol 105 (9) ◽  
pp. 2966-2973 ◽  
Author(s):  
Huixin Qi ◽  
Jia Lu ◽  
Jiajun Li ◽  
Meiyu Wang ◽  
Yunting Xu ◽  
...  
Keyword(s):  
Antitumor Activity ◽  
In Vivo Evaluation ◽  
Ester Prodrugs

The PI3K inhibitor BKM120 has potent antitumor activity in melanoma brain metastases in vitro and in vivo.

2013 ◽  
Vol 31 (15_suppl) ◽  
pp. e20050-e20050 ◽  
Author(s):  
Friedegund Elke Meier ◽  
Heike Niessner ◽  
Jennifer Schmitz ◽  
Andreas Schmid ◽  
Carsten Calaminus ◽  
...  
Keyword(s):  
Antitumor Activity ◽  
Brain Metastases ◽  
Metastatic Melanoma ◽  
Conditioned Medium ◽  
Melanoma Cells ◽  
Pi3k Inhibitor ◽  
Survival Pathway ◽  
Melanoma Brain Metastases

e20050 Background: In melanoma, the RAF-MEK-ERK and PI3K-AKT signaling pathways play a major role in melanoma progression and drug resistance. On the basis of significant improvement in overall survival, the BRAF inhibitor vemurafenib gained FDA approval for the treatment of patients with metastatic BRAFV600E mutated melanoma. However, vemurafenib appears to be less effective in melanoma brain metastases, and brain metastases are the most common cause of death in patients with metastatic melanoma. In our previous study we reported that the AKT survival pathway is hyperactivated in melanoma brain metastases. Methods: The current study aims to investigate the mechanisms of AKT hyperactivation and the antitumor activity of the PI3K inhibitor BKM120 in melanoma brain metastases in vitro and in vivo. Results: To simulate the tumor environment of brain metastases and extracerebral metastases, brain and matched extracerebral metastatic melanoma cells were stimulated by astrocyte- and fibroblast-conditioned medium, respectively. Both brain and extracerebral metastatic melanoma cells stimulated by astrocyte-conditioned medium showed higher AKT activation and invasiveness in a transwell matrigel invasion assay than cells stimulated by fibroblast-conditioned medium. The PI3K inhibitor BKM120 inhibited the phosphorylation of AKT and the growth of >10 newly isolated cell lines derived from melanoma brain metastases achieving growth inhibition rates of up to 80%. These effects did not depend on BRAF, NRAS or KIT mutation status. Furthermore, BKM120 potently induced apoptosis in brain metastatic melanoma cells and significantly inhibited the tumor growth of human brain metastatic melanoma cells in the brain of nude mice as shown by MRI scans. Conclusions: Brain-derived factors induce hyperactivation of the AKT survival pathway and promote invasiveness and drug resistance of melanoma cells in the brain. The PI3K inhibitor BKM120 inhibits activation of the AKT survival pathway and demonstrates potent antitumor activity in melanoma brain metastases in vitro and in vivo.

Preclinical in vitro and in vivo evaluation of antitumor activity of poly (ADP-ribose) polymerase inhibition and trastuzumab combined therapy in HER2-overexpressing breast cancer.

2014 ◽  
Vol 32 (15_suppl) ◽  
pp. 622-622
Author(s):  
Ignacio Tusquets ◽  
Jetzabel Garcia-Parra ◽  
Alba Dalmases ◽  
Beatriz Morancho ◽  
Oriol Arpi ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Antitumor Activity ◽  
Combined Therapy ◽  
In Vivo Evaluation

scholarly journals Antitumor activity of dichloroacetate on C6 glioma cell: in vitro and in vivo evaluation

2013 ◽  
pp. 189 ◽  
Author(s):  
Xuan Zhang ◽  
Duan ◽  
Zhao ◽  
Ren ◽  
Wang ◽  
...  
Keyword(s):  
Antitumor Activity ◽  
Glioma Cell ◽  
C6 Glioma ◽  
In Vivo Evaluation ◽  
C6 Glioma Cell

scholarly journals In Vitro and In Vivo Antitumor Activity of Indolo[2,3-b] Quinolines, Natural Product Analogs from Neocryptolepine Alkaloid

Molecules ◽  
2021 ◽  
Vol 26 (3) ◽  
pp. 754
Author(s):  
Najla Altwaijry ◽  
Samah El-Ghlban ◽  
Ibrahim E.-T. El Sayed ◽  
Mohamed El-Bahnsawye ◽  
Asmaa I. Bayomi ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Antitumor Activity ◽  
Apoptotic Cell ◽  
Ehrlich Ascites Carcinoma ◽  
Immunological Study ◽  
In Vivo Evaluation ◽  
Reference Drug ◽  
Dpph Method

Neocryptolepine (5-methyl-5H-indolo[2,3-b] quinoline) analogs were synthesized and evaluated in vitro and in vivo for their effect versus Ehrlich ascites carcinoma (EAC). The analogs showed stronger cytotoxic activity against EAC cells than the reference drug. The in vivo evaluation of the target compounds against EAC-induced solid tumor in the female albino Swiss mice revealed a remarkable decrease in the tumor volume (TV) and hepatic lipid peroxidation. A noticeable increase of both superoxide dismutase (SOD) and catalase (CAT) levels was reported (p < 0.001), which set-forth proof of their antioxidant effect. In addition, the in vitro antioxidant activity of the neocryptolepine analogs was screened out using the DPPH method and showed promising activities activity. The histopathological investigations affirmed that the tested analogs have a remarkable curative effect on solid tumors with minimal side-effect on the liver. The study also includes illustrated mechanism of the antitumor activity at the cell level by flow cytometry. The cell cycle analysis showed that the neocryptolepine analogs extensively increase the aggregation of tumor cells in three phases of the cell cycle (G0/G1, S and G2/M) with the emergence of a hypo-diploid DNA content peak (sub-G1) in the cell cycle experiments, which is a clear-cut for the apoptotic cell population. Furthermore, the immunological study manifested a significant elevation in splenic lymphocyte count (p < 0.001) with the elevation of the responsiveness of lymphocytes to phytohemagglutinin (PHA). These results indicate that these naturally-based neocryptolepine alkaloids exhibit marked antitumor activity in vivo and represent an important lead in the development of natural-based anticancer drugs.

In Vitro and In Vivo Evaluation of Antitumor Activity of Ligustrum robustum, A Chinese Herbal Tea

2018 ◽  
Vol 25 (6) ◽  
pp. 425-430 ◽  
Author(s):  
Hao-jiang Zuo ◽  
Shan Liu ◽  
Chun Yan ◽  
Li-man Li ◽  
Xiao-fang Pei
Keyword(s):  
Antitumor Activity ◽  
Herbal Tea ◽  
In Vivo Evaluation ◽  
Chinese Herbal ◽  
Chinese Herbal Tea

In vitro and in vivo evaluation of the anti-inflammatory effects of Arzanol from Helichrysum italicum

Planta Medica ◽  
2010 ◽  
Vol 76 (12) ◽  
Author(s):  
J Bauer ◽  
F Dehm ◽  
A Koeberle ◽  
F Pollastro ◽  
G Appendino ◽  
...  
Keyword(s):  
In Vivo Evaluation ◽  
Anti Inflammatory
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