scholarly journals Nanoemulsion loaded with lycobetaine–oleic acid ionic complex: physicochemical characteristics, in vitro, in vivo evaluation, and antitumor activity

2013 ◽  
pp. 1959 ◽  
Author(s):  
Hui Zhao ◽  
Lu ◽  
Tao Gong ◽  
zhirong zhang
Keyword(s):  
Oleic Acid ◽  
Antitumor Activity ◽  
Physicochemical Characteristics ◽  
Ionic Complex ◽  
In Vivo Evaluation

scholarly journals Enhanced Antitumor Activity of Monophosphate Ester Prodrugs of Gemcitabine: In Vitro and In Vivo Evaluation

2016 ◽  
Vol 105 (9) ◽  
pp. 2966-2973 ◽  
Author(s):  
Huixin Qi ◽  
Jia Lu ◽  
Jiajun Li ◽  
Meiyu Wang ◽  
Yunting Xu ◽  
...  
Keyword(s):  
Antitumor Activity ◽  
In Vivo Evaluation ◽  
Ester Prodrugs

Preclinical in vitro and in vivo evaluation of antitumor activity of poly (ADP-ribose) polymerase inhibition and trastuzumab combined therapy in HER2-overexpressing breast cancer.

2014 ◽  
Vol 32 (15_suppl) ◽  
pp. 622-622
Author(s):  
Ignacio Tusquets ◽  
Jetzabel Garcia-Parra ◽  
Alba Dalmases ◽  
Beatriz Morancho ◽  
Oriol Arpi ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Antitumor Activity ◽  
Combined Therapy ◽  
In Vivo Evaluation

scholarly journals Antitumor activity of dichloroacetate on C6 glioma cell: in vitro and in vivo evaluation

2013 ◽  
pp. 189 ◽  
Author(s):  
Xuan Zhang ◽  
Duan ◽  
Zhao ◽  
Ren ◽  
Wang ◽  
...  
Keyword(s):  
Antitumor Activity ◽  
Glioma Cell ◽  
C6 Glioma ◽  
In Vivo Evaluation ◽  
C6 Glioma Cell

scholarly journals In Vitro and In Vivo Antitumor Activity of Indolo[2,3-b] Quinolines, Natural Product Analogs from Neocryptolepine Alkaloid

Molecules ◽  
2021 ◽  
Vol 26 (3) ◽  
pp. 754
Author(s):  
Najla Altwaijry ◽  
Samah El-Ghlban ◽  
Ibrahim E.-T. El Sayed ◽  
Mohamed El-Bahnsawye ◽  
Asmaa I. Bayomi ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Antitumor Activity ◽  
Apoptotic Cell ◽  
Ehrlich Ascites Carcinoma ◽  
Immunological Study ◽  
In Vivo Evaluation ◽  
Reference Drug ◽  
Dpph Method

Neocryptolepine (5-methyl-5H-indolo[2,3-b] quinoline) analogs were synthesized and evaluated in vitro and in vivo for their effect versus Ehrlich ascites carcinoma (EAC). The analogs showed stronger cytotoxic activity against EAC cells than the reference drug. The in vivo evaluation of the target compounds against EAC-induced solid tumor in the female albino Swiss mice revealed a remarkable decrease in the tumor volume (TV) and hepatic lipid peroxidation. A noticeable increase of both superoxide dismutase (SOD) and catalase (CAT) levels was reported (p < 0.001), which set-forth proof of their antioxidant effect. In addition, the in vitro antioxidant activity of the neocryptolepine analogs was screened out using the DPPH method and showed promising activities activity. The histopathological investigations affirmed that the tested analogs have a remarkable curative effect on solid tumors with minimal side-effect on the liver. The study also includes illustrated mechanism of the antitumor activity at the cell level by flow cytometry. The cell cycle analysis showed that the neocryptolepine analogs extensively increase the aggregation of tumor cells in three phases of the cell cycle (G0/G1, S and G2/M) with the emergence of a hypo-diploid DNA content peak (sub-G1) in the cell cycle experiments, which is a clear-cut for the apoptotic cell population. Furthermore, the immunological study manifested a significant elevation in splenic lymphocyte count (p < 0.001) with the elevation of the responsiveness of lymphocytes to phytohemagglutinin (PHA). These results indicate that these naturally-based neocryptolepine alkaloids exhibit marked antitumor activity in vivo and represent an important lead in the development of natural-based anticancer drugs.

scholarly journals EVALUASI IN VITRO-IN VIVO FILM TRANDERMAL DILTIAZEM HCL DENGAN PENINGKAT PENETRASI PEG 400 SEBAGAI ANTIHIPERTENSI

2019 ◽  
Vol 16 (01) ◽  
pp. 1
Author(s):  
Yulias Ninik Windriyati ◽  
Risha Fillah Fithria ◽  
Fitria Dwi Kurniawati ◽  
Ulfa Risalatul Mukaromah
Keyword(s):  
Blood Pressure ◽  
Physicochemical Characteristics ◽  
Penetration Enhancer ◽  
Transdermal Patch ◽  
In Vivo Evaluation ◽  
Peg 400 ◽  
Transdermal Patches ◽  
Diltiazem Hcl

ABSTRACTDiltiazem HCL is an antihypertensive that low oral bioavailability of 40%, so developed to transdermal preparations. A matrix type of transdermal patch of diltiazem HCl was prepared using polyvinyl alcohol and ethyl cellulose with PEG 400 as penetration enhancer. In vitro-in vivo evaluation were conducted to asses drug permeation through the skin and determine the effectiveness of transdermal film as an antihypertensive drug. Transdermal patches of diltiazem HCl were evaluated for physicochemical characteristics weight variation, thickness, folding endurance, moisture uptake, and drug content. In vitro permeation study was conducted using commercial semi permeable membrane in Franz diffusion cell. In vivo activity study was evaluated on male rat Wistar that induced NaCl with CODA non-invasive blood pressure method. Transdermal patches of diltiazem HCl were found no significant differences in terms of physicochemical characteristics. The in vitro skin permeation profiles showed increased flux values with the increase of PEG 400 as a penetration enhancer. The in vivo evaluation showed a reduction in systolic and diastolic blood pressure within one hour after the drug administration. Diltiazem HCl was able penetration into skin, absorbed in blood circulation and effective as antihypertensive via transdermal route.Keywords : antihypertension, diltiazem HCl, PEG 400, transdermal patch

In Vitro and In Vivo Evaluation of Antitumor Activity of Ligustrum robustum, A Chinese Herbal Tea

2018 ◽  
Vol 25 (6) ◽  
pp. 425-430 ◽  
Author(s):  
Hao-jiang Zuo ◽  
Shan Liu ◽  
Chun Yan ◽  
Li-man Li ◽  
Xiao-fang Pei
Keyword(s):  
Antitumor Activity ◽  
Herbal Tea ◽  
In Vivo Evaluation ◽  
Chinese Herbal ◽  
Chinese Herbal Tea

In vitro and in vivo evaluation of the anti-inflammatory effects of Arzanol from Helichrysum italicum

Planta Medica ◽  
2010 ◽  
Vol 76 (12) ◽  
Author(s):  
J Bauer ◽  
F Dehm ◽  
A Koeberle ◽  
F Pollastro ◽  
G Appendino ◽  
...  
Keyword(s):  
In Vivo Evaluation ◽  
Anti Inflammatory
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