scholarly journals A nanoparticulate injectable hydrogel as a tissue engineering scaffold for multiple growth factor delivery for bone regeneration

2012 ◽  
pp. 47 ◽  
Author(s):  
Dyondi ◽  
Webster ◽  
R Banerjee
Keyword(s):  
Tissue Engineering ◽  
Growth Factor ◽  
Bone Regeneration ◽  
Tissue Engineering Scaffold ◽  
Growth Factor Delivery ◽  
Injectable Hydrogel

scholarly journals Double-layered microsphere based dual growth factor delivery system for guided bone regeneration

RSC Advances ◽  
2018 ◽  
Vol 8 (30) ◽  
pp. 16503-16512 ◽  
Author(s):  
Chun Xu ◽  
Jia Xu ◽  
Lan Xiao ◽  
Zhihao Li ◽  
Yin Xiao ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Growth Factor ◽  
Bone Regeneration ◽  
Delivery System ◽  
Drug Delivery Systems ◽  
Guided Bone Regeneration ◽  
Delivery Systems ◽  
Growth Factor Delivery ◽  
Dual Growth Factor Delivery

Microsphere based drug delivery systems show great advantages for tissue engineering.

scholarly journals Mesoporous bioactive glasses: structure characteristics, drug/growth factor delivery and bone regeneration application

2012 ◽  
Vol 2 (3) ◽  
pp. 292-306 ◽  
Author(s):  
Chengtie Wu ◽  
Jiang Chang
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Growth Factor ◽  
Bone Tissue Engineering ◽  
Bone Regeneration ◽  
Bone Tissue ◽  
Growth Factor Delivery ◽  
Bioactive Glasses ◽  
The Past

The impact of bone diseases and trauma in the whole world has increased significantly in the past decades. Bioactive glasses are regarded as an important bone regeneration material owing to their generally excellent osteoconductivity and osteostimulativity. A new class of bioactive glass, referred to as mesoporous bioglass (MBG), was developed 7 years ago, which possess a highly ordered mesoporous channel structure and a highly specific surface area. The study of MBG for drug/growth factor delivery and bone tissue engineering has grown significantly in the past several years. In this article, we review the recent advances of MBG materials, including the preparation of different forms of MBG, composition–structure relationship, efficient drug/growth factor delivery and bone tissue engineering application. By summarizing our recent research, the interaction of MBG scaffolds with bone-forming cells, the effect of drug/growth factor delivery on proliferation and differentiation of tissue cells and the in vivo osteogenesis of MBG scaffolds are highlighted. The advantages and limitations of MBG for drug delivery and bone tissue engineering have been compared with microsize bioactive glasses and nanosize bioactive glasses. The future perspective of MBG is discussed for bone regeneration application by combining drug delivery with bone tissue engineering and investigating the in vivo osteogenesis mechanism in large animal models.

scholarly journals Advances in Growth Factor Delivery for Bone Tissue Engineering

2021 ◽  
Vol 22 (2) ◽  
pp. 903
Author(s):  
Érica Resende Oliveira ◽  
Lei Nie ◽  
Daria Podstawczyk ◽  
Ahmad Allahbakhsh ◽  
Jithendra Ratnayake ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Extracellular Matrix ◽  
Growth Factors ◽  
Growth Factor ◽  
Bone Tissue Engineering ◽  
Bone Regeneration ◽  
Bone Tissue ◽  
Bone Repair ◽  
Bone Diseases ◽  
Growth Factor Delivery

Shortcomings related to the treatment of bone diseases and consequent tissue regeneration such as transplants have been addressed to some extent by tissue engineering and regenerative medicine. Tissue engineering has promoted structures that can simulate the extracellular matrix and are capable of guiding natural bone repair using signaling molecules to promote osteoinduction and angiogenesis essential in the formation of new bone tissues. Although recent studies on developing novel growth factor delivery systems for bone repair have attracted great attention, taking into account the complexity of the extracellular matrix, scaffolding and growth factors should not be explored independently. Consequently, systems that combine both concepts have great potential to promote the effectiveness of bone regeneration methods. In this review, recent developments in bone regeneration that simultaneously consider scaffolding and growth factors are covered in detail. The main emphasis in this overview is on delivery strategies that employ polymer-based scaffolds for spatiotemporal-controlled delivery of both single and multiple growth factors in bone-regeneration approaches. From clinical applications to creating alternative structural materials, bone tissue engineering has been advancing constantly, and it is relevant to regularly update related topics.

Triple Growth Factor Delivery Promotes Functional Bone Regeneration Following Composite Musculoskeletal Trauma

2021 ◽  
Author(s):  
Ramesh Subbiah ◽  
Marissa A. Ruehle ◽  
Brett S. Klosterhoff ◽  
Angela S.P. Lin ◽  
Marian H. Hettiaratchi ◽  
...  
Keyword(s):  
Growth Factor ◽  
Bone Regeneration ◽  
Growth Factor Delivery ◽  
Musculoskeletal Trauma

Extracellular matrix-inspired growth factor delivery systems for bone regeneration

2015 ◽  
Vol 94 ◽  
pp. 41-52 ◽  
Author(s):  
Mikaël M. Martino ◽  
Priscilla S. Briquez ◽  
Kenta Maruyama ◽  
Jeffrey A. Hubbell
Keyword(s):  
Extracellular Matrix ◽  
Growth Factor ◽  
Bone Regeneration ◽  
Delivery Systems ◽  
Growth Factor Delivery

scholarly journals AnIn VitroInvestigation of Platelet-Rich Plasma-Gel as a Cell and Growth Factor Delivery Vehicle for Tissue Engineering

2016 ◽  
Vol 22 (1) ◽  
pp. 49-58 ◽  
Author(s):  
Jagoda M. Jalowiec ◽  
Matteo D'Este ◽  
Jennifer Jane Bara ◽  
Jessica Denom ◽  
Ursula Menzel ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Growth Factor ◽  
Platelet Rich Plasma ◽  
Growth Factor Delivery ◽  
Delivery Vehicle ◽  
A Cell
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