scholarly journals Novel Timosaponin AIII-Based Multifunctional Liposomal Delivery System for Synergistic Therapy Against Hepatocellular Carcinoma Cancer

2021 ◽  
Vol Volume 16 ◽  
pp. 5531-5550
Author(s):  
Lijuan Zhang ◽  
Shengan Zhang ◽  
Min Jiang ◽  
Lu Lu ◽  
Yue Ding ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Delivery System ◽  
Liposomal Delivery ◽  
Timosaponin Aiii

scholarly journals Synthesis and Characterization of Chitosan-Based Nanodelivery Systems to Enhance the Anticancer Effect of Sorafenib Drug in Hepatocellular Carcinoma and Colorectal Adenocarcinoma Cells

Nanomaterials ◽  
2021 ◽  
Vol 11 (2) ◽  
pp. 497
Author(s):  
Umme Ruman ◽  
Kalaivani Buskaran ◽  
Giorgia Pastorin ◽  
Mas Jaffri Masarudin ◽  
Sharida Fakurazi ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Drug Delivery ◽  
Cell Lines ◽  
Delivery System ◽  
Colorectal Adenocarcinoma ◽  
Dermal Fibroblast ◽  
Spherical Shape ◽  
Ht29 Cell ◽  
Normal Human Dermal Fibroblast ◽  
Cancer Management

The formation of two nanodelivery systems, Sorafenib (SF)-loaded chitosan (SF-CS) and their folate-coated (SF-CS-FA) nanoparticles (NPs), were developed to enhance SF drug delivery on human Hepatocellular Carcinoma (HepG2) and Colorectal Adenocarcinoma (HT29) cell lines. The ionic gelation method was adopted to synthesize the NPs. The characterizations were performed by DLS, FESEM, TEM, XRD, TGA, FTIR, and UV-visible spectroscopy. It was found that 83.7 ± 2.4% and 87.9 ± 1.1% of encapsulation efficiency; 18.2 ± 1.3% and 19.9 ± 1.4% of loading content; 76.3 ± 13.7 nm and 81.6 ± 12.9 nm of hydrodynamic size; 60–80 nm and 70–100 nm of TEM; and FESEM sizes of near-spherical shape were observed, respectively, for SF-CS and SF-CS-FA nanoparticles. The SF showed excellent release from the nanoparticles under pH 4.8 PBS solution, indicating a good delivery system for tumor cells. The cytotoxicity study revealed their better anticancer action towards HepG2 and HT29 cell lines compared to the free sorafenib. Moreover, both NPs systems showed negligible toxicity to normal Human Dermal Fibroblast adult cells (HDFa). This is towards an enhanced anticancer drug delivery system with sustained-release properties for better cancer management.

scholarly journals Self‐Activated Cascade‐Responsive Sorafenib and USP22 shRNA Co‐Delivery System for Synergetic Hepatocellular Carcinoma Therapy

2021 ◽  
pp. 2003042
Author(s):  
Shengjun Xu ◽  
Sunbin Ling ◽  
Qiaonan Shan ◽  
Qianwei Ye ◽  
Qifan Zhan ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Delivery System

scholarly journals Aptamer–drug conjugate: targeted delivery of doxorubicin in a HER3 aptamer-functionalized liposomal delivery system reduces cardiotoxicity

2018 ◽  
Vol Volume 13 ◽  
pp. 763-776 ◽  
Author(s):  
Xiao-qian Dou ◽  
Hua Wang ◽  
Jing Zhang ◽  
Fang Wang ◽  
Gui-li Xu ◽  
...  
Keyword(s):  
Delivery System ◽  
Targeted Delivery ◽  
Drug Conjugate ◽  
Liposomal Delivery

Multivesicular liposome: A lipid-based drug delivery system for efficient drug delivery

2021 ◽  
Vol 27 ◽  
Author(s):  
Bapi Gorain ◽  
Bandar E. Al-Dhubiab ◽  
Anroop Nair ◽  
Prashant Kesharwani ◽  
Manisha Pandey ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Sustained Release ◽  
Delivery System ◽  
Targeted Delivery ◽  
Drug Loading ◽  
Therapeutic Agents ◽  
Laboratory Research ◽  
Efficacy And Safety ◽  
Liposomal Delivery ◽  
Proteins And Peptides

: The advancement of delivery tools for therapeutic agents has brought several novel formulations with increased drug loading, sustained release, targeted delivery, and prolonged efficacy. Amongst the several novel delivery approaches, multivesicular liposome has gained potential interest because this delivery system possesses the above advantages. In addition, this multivesicular liposomal delivery prevents degradation of the entrapped drug within the physiological environment while administered. The special structure of the vesicles allowed successful entrapment of hydrophobic and hydrophilic therapeutic agents, including proteins and peptides. Furthermore, this novel formulation could maintain the desired drug concentration in the plasma for a prolonged period, which helps to reduce the dosing frequencies, improve bioavailability, and safety. This tool could also provide stability of the formulation, and finally gaining patient compliance. Several multivesicular liposomes received approval for clinical research, while others are at different stages of laboratory research. In this review, we have focused on the preparation of multivesicular liposomes along with their application in different ailments for the improvement of the performance of the entrapped drug. Moreover, the challenges of delivering multivesicular vesicles have also been emphasized. Overall, it could be inferred that multivesicular liposomal delivery is a novel platform of advanced drug delivery with improved efficacy and safety.

Liposomal delivery system for taxol

1997 ◽  
Vol 83 (1) ◽  
pp. 87-90 ◽  
Author(s):  
Meng-Feng Shieh ◽  
I-Ming Chu ◽  
Chau-Jen Lee ◽  
Pei Kan ◽  
Dou-Mong Hau ◽  
...  
Keyword(s):  
Delivery System ◽  
Liposomal Delivery

An Integrated Therapeutic Delivery System for Enhanced Treatment of Hepatocellular Carcinoma

2018 ◽  
Vol 28 (18) ◽  
pp. 1706600 ◽  
Author(s):  
Zhou Ye ◽  
Wen-Rui Wu ◽  
Yu-Fei Qin ◽  
Jing Hu ◽  
Chao Liu ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Delivery System ◽  
Therapeutic Delivery
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