scholarly journals Nanoparticle-Mediated Drug Delivery for the Treatment of Cardiovascular Diseases

2020 ◽  
Vol Volume 15 ◽  
pp. 3741-3769 ◽  
Author(s):  
Rajasekharreddy Pala ◽  
VT Anju ◽  
Madhu Dyavaiah ◽  
Siddhardha Busi ◽  
Surya M Nauli
Keyword(s):  
Drug Delivery ◽  
Cardiovascular Diseases

scholarly journals Targeting Inflammation With Nanosized Drug Delivery Platforms in Cardiovascular Diseases: Immune Cell Modulation in Atherosclerosis

2018 ◽  
Vol 6 ◽  
Author(s):  
Antonio Cervadoro ◽  
Roberto Palomba ◽  
Giuseppe Vergaro ◽  
Roberta Cecchi ◽  
Luca Menichetti ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cardiovascular Diseases ◽  
Immune Cell

scholarly journals A combined low-frequency electromagnetic and fluidic stimulation for a controlled drug release from superparamagnetic calcium phosphate nanoparticles: potential application for cardiovascular diseases

2018 ◽  
Vol 15 (144) ◽  
pp. 20180236 ◽  
Author(s):  
Alessandra Marrella ◽  
Michele Iafisco ◽  
Alessio Adamiano ◽  
Stefano Rossi ◽  
Maurizio Aiello ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Animal Model ◽  
Cardiovascular Diseases ◽  
Drug Release ◽  
Biological Effects ◽  
Low Frequency ◽  
Controlled Drug Release ◽  
Drug Dose

Alternative drug delivery approaches to treat cardiovascular diseases are currently under intense investigation. In this domain, the possibility to target the heart and tailor the amount of drug dose by using a combination of magnetic nanoparticles (NPs) and electromagnetic devices is a fascinating approach. Here, an electromagnetic device based on Helmholtz coils was generated for the application of low-frequency magnetic stimulations to manage drug release from biocompatible superparamagnetic Fe-hydroxyapatite NPs (FeHAs). Integrated with a fluidic circuit mimicking the flow of the cardiovascular environment, the device was efficient to trigger the release of a model drug (ibuprofen) from FeHAs as a function of the applied frequencies. Furthermore, the biological effects on the cardiac system of the identified electromagnetic exposure were assessed in vitro and in vivo by acute stimulation of isolated adult cardiomyocytes and in an animal model. The cardio-compatibility of FeHAs was also assessed in vitro and in an animal model. No alterations of cardiac electrophysiological properties were observed in both cases, providing the evidence that the combination of low-frequency magnetic stimulations and FeHAs might represent a promising strategy for controlled drug delivery to the failing heart.

Prospective of Natural Gum Nanoparticulate Against Cardiovascular Disorders

2019 ◽  
Vol 13 (3) ◽  
pp. 197-211
Author(s):  
Aakash Deep ◽  
Neeraj Rani ◽  
Ashok Kumar ◽  
Rimmy Nandal ◽  
Prabodh C. Sharma ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cardiovascular Diseases ◽  
Drug Release ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Natural Polymers ◽  
Stabilizing Agents ◽  
Synthetic Materials ◽  
Materials Used ◽  
Cellular Components

Background: Objective: Various natural gums can be synergistically used in nanoparticulate drug delivery systems to treat cardiovascular diseases. Nanotechnology has been integrated into healthcare in terms of theranostics. In this review, we consider various natural gums that can be used for the preparation of nanoparticles and their role to treat cardiovascular disease. Methods: Nanoparticles can carry drugs at nanoscales and deliver them to the targeted sites with the desired pattern of drug release. They have specialized uptake mechanisms (e.g. - absorptive endocytosis) which improve the bioavailability of drugs. Results: By considering cardiovascular diseases at the molecular level, it is possible to modify the materials with nanotechnology and apply nano-formulations efficiently as compared with conventional preparations, due to the fact that the extracellular matrix (ECM) comprises components at the nanoscale range. The interactions of ECM components with cellular components occur at the nanoscale, therefore the nanomaterials have the potential to maintain the nanoscale properties of cells. The synthetic materials used to develop the nanoparticulate drug delivery system may cause toxicity. Conclusion: This problem can be overcome by using natural polymers. Natural gums can be used in nanoparticulate drug delivery systems as reducing and stabilizing agents and in some cases; they may directly or indirectly influence the rate of drug release and absorption from the preparation.

scholarly journals Extracellular Vesicles in Cardiovascular Diseases: Alternative Biomarker Sources, Therapeutic Agents, and Drug Delivery Carriers

2019 ◽  
Vol 20 (13) ◽  
pp. 3272 ◽  
Author(s):  
Suet Yen Chong ◽  
Choon Keong Lee ◽  
Chenyuan Huang ◽  
Yi Hsuan Ou ◽  
Christopher J. Charles ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cardiovascular Diseases ◽  
Extracellular Vesicles ◽  
Biological Fluids ◽  
Therapeutic Agents ◽  
Bioactive Molecules ◽  
Intrinsic Activity ◽  
Diagnostic Tools ◽  
Alternative Source ◽  
Technological Advantage

Cardiovascular diseases (CVD) represent the leading cause of morbidity and mortality globally. The emerging role of extracellular vesicles (EVs) in intercellular communication has stimulated renewed interest in exploring the potential application of EVs as tools for diagnosis, prognosis, and therapy in CVD. The ubiquitous nature of EVs in biological fluids presents a technological advantage compared to current diagnostic tools by virtue of their notable stability. EV contents, such as proteins and microRNAs, represent specific signatures of cellular activation or injury. This feature positions EVs as an alternative source of biomarkers. Furthermore, their intrinsic activity and immunomodulatory properties offer EVs unique opportunities to act as therapeutic agents per se or to serve as drug delivery carriers by acting as miniaturized vehicles incorporating bioactive molecules. In this article, we aim to review the recent advances and applications of EV-based biomarkers and therapeutics. In addition, the potential of EVs as a drug delivery and theranostic platform for CVD will also be discussed.

scholarly journals Optimization of preferential heart drug delivery targeting cardiovascular diseases

2019 ◽  
Vol 11 (2) ◽  
pp. 225
Author(s):  
C. Deflers ◽  
A.C. Le Fèvre ◽  
F. Puech ◽  
G. Pidoux ◽  
R. Fischmeister
Keyword(s):  
Drug Delivery ◽  
Cardiovascular Diseases

scholarly journals Advances in healthcare wearable devices

2021 ◽  
Vol 5 (1) ◽  
Author(s):  
Sheikh M. A. Iqbal ◽  
Imadeldin Mahgoub ◽  
E Du ◽  
Mary Ann Leavitt ◽  
Waseem Asghar
Keyword(s):  
Drug Delivery ◽  
Cardiovascular Diseases ◽  
Drug Delivery System ◽  
Healthcare System ◽  
Delivery System ◽  
Wearable Devices ◽  
Future Perspectives ◽  
Muscle Disorders ◽  
Personalized Healthcare ◽  
Different Types

AbstractWearable devices have found numerous applications in healthcare ranging from physiological diseases, such as cardiovascular diseases, hypertension and muscle disorders to neurocognitive disorders, such as Parkinson’s disease, Alzheimer’s disease and other psychological diseases. Different types of wearables are used for this purpose, for example, skin-based wearables including tattoo-based wearables, textile-based wearables, and biofluidic-based wearables. Recently, wearables have also shown encouraging improvements as a drug delivery system; therefore, enhancing its utility towards personalized healthcare. These wearables contain inherent challenges, which need to be addressed before their commercialization as a fully personalized healthcare system. This paper reviews different types of wearable devices currently being used in the healthcare field. It also highlights their efficacy in monitoring different diseases and applications of healthcare wearable devices (HWDs) for diagnostic and treatment purposes. Additionally, current challenges and limitations of these wearables in the field of healthcare along with their future perspectives are also reviewed.

scholarly journals ncRNAs in Therapeutics: Challenges and Limitations in Nucleic Acid-Based Drug Delivery

2021 ◽  
Vol 22 (21) ◽  
pp. 11596
Author(s):  
Miguel Hueso ◽  
Adrián Mallén ◽  
Marc Suñé-Pou ◽  
Josep M. Aran ◽  
Josep M. Suñé-Negre ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Clinical Practice ◽  
Cardiovascular Diseases ◽  
Side Effects ◽  
Future Trends ◽  
Biological Mechanisms ◽  
Key Issues ◽  
Non Coding Rnas ◽  
Therapeutic Tools ◽  
Target Side

Non-coding RNAs (ncRNAs) are emerging therapeutic tools but there are barriers to their translation to clinical practice. Key issues concern the specificity of the targets, the delivery of the molecules, and their stability, while avoiding “on-target” and “off-target” side effects. In this “ncRNA in therapeutics’’ issue, we collect several studies of the differential expression of ncRNAs in cardiovascular diseases, bone metabolism-related disorders, neurology, and oncology, and their potential to be used as biomarkers or therapeutic targets. Moreover, we review recent advances in the use of antisense ncRNAs in targeted therapies with a particular emphasis on their basic biological mechanisms, their translational potential, and future trends.

Biologically Responsive Nanosystems Targeting Cardiovascular Diseases Therapy

2021 ◽  
Vol 18 ◽  
Author(s):  
Zhiling Song ◽  
Kechen Song ◽  
Yi Xiao ◽  
Hui Guo ◽  
Yizhun Zhu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cardiovascular Diseases ◽  
Stimuli Responsive ◽  
Significant Progress ◽  
Mortality And Morbidity ◽  
Delivery Performance ◽  
Non Invasive ◽  
On Demand ◽  
Wide Range ◽  
Made In

: Cardiovascular Diseases (CVD) remain the leading cause of mortality and morbidity worldwide. To date, significant progress has been made in developing stimuli-responsive nanosystems that can intrinsically interact with pathological microenvironment to achieve site-specific delivery along with on-demand drug release for precise CVD treatment. Herein, this review summarizes recent advances on smart nanosystems in response to a wide range of biological cues, including pH, enzymes, ROS, shear force, ATP, etc., which can boost drug delivery performance or monitor disease progression in a non-invasive manner. The designs, compositions and main outcomes of the single and multi- responsive nanosystems for drug delivery and/or detection purposes are provided and discussed.

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