scholarly journals Targeting Inflammation With Nanosized Drug Delivery Platforms in Cardiovascular Diseases: Immune Cell Modulation in Atherosclerosis

2018 ◽  
Vol 6 ◽  
Author(s):  
Antonio Cervadoro ◽  
Roberto Palomba ◽  
Giuseppe Vergaro ◽  
Roberta Cecchi ◽  
Luca Menichetti ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cardiovascular Diseases ◽  
Immune Cell

scholarly journals Drug Delivery: Immune Cell-Mediated Biodegradable Theranostic Nanoparticles for Melanoma Targeting and Drug Delivery (Small 10/2017)

Small ◽  
2017 ◽  
Vol 13 (10) ◽  
Author(s):  
Zhiwei Xie ◽  
Yixue Su ◽  
Gloria B. Kim ◽  
Erhan Selvi ◽  
Chuying Ma ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Immune Cell ◽  
Theranostic Nanoparticles

scholarly journals A combined low-frequency electromagnetic and fluidic stimulation for a controlled drug release from superparamagnetic calcium phosphate nanoparticles: potential application for cardiovascular diseases

2018 ◽  
Vol 15 (144) ◽  
pp. 20180236 ◽  
Author(s):  
Alessandra Marrella ◽  
Michele Iafisco ◽  
Alessio Adamiano ◽  
Stefano Rossi ◽  
Maurizio Aiello ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Animal Model ◽  
Cardiovascular Diseases ◽  
Drug Release ◽  
Biological Effects ◽  
Low Frequency ◽  
Controlled Drug Release ◽  
Drug Dose

Alternative drug delivery approaches to treat cardiovascular diseases are currently under intense investigation. In this domain, the possibility to target the heart and tailor the amount of drug dose by using a combination of magnetic nanoparticles (NPs) and electromagnetic devices is a fascinating approach. Here, an electromagnetic device based on Helmholtz coils was generated for the application of low-frequency magnetic stimulations to manage drug release from biocompatible superparamagnetic Fe-hydroxyapatite NPs (FeHAs). Integrated with a fluidic circuit mimicking the flow of the cardiovascular environment, the device was efficient to trigger the release of a model drug (ibuprofen) from FeHAs as a function of the applied frequencies. Furthermore, the biological effects on the cardiac system of the identified electromagnetic exposure were assessed in vitro and in vivo by acute stimulation of isolated adult cardiomyocytes and in an animal model. The cardio-compatibility of FeHAs was also assessed in vitro and in an animal model. No alterations of cardiac electrophysiological properties were observed in both cases, providing the evidence that the combination of low-frequency magnetic stimulations and FeHAs might represent a promising strategy for controlled drug delivery to the failing heart.

scholarly journals Nanoparticle-Mediated Drug Delivery for the Treatment of Cardiovascular Diseases

2020 ◽  
Vol Volume 15 ◽  
pp. 3741-3769 ◽  
Author(s):  
Rajasekharreddy Pala ◽  
VT Anju ◽  
Madhu Dyavaiah ◽  
Siddhardha Busi ◽  
Surya M Nauli
Keyword(s):  
Drug Delivery ◽  
Cardiovascular Diseases

scholarly journals Abstract 35: 3D in vitro system for immuno-oncology: Real-time imaging of drug delivery, tumoroids, and immune cell activity

2019 ◽  
Author(s):  
Eric O. McGhee ◽  
Alex J. McGhee ◽  
Derek L. Hood ◽  
Kylie E. Van Meter ◽  
Juan M. Urueña ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Real Time ◽  
Immune Cell ◽  
Cell Activity ◽  
In Vitro System ◽  
Real Time Imaging

scholarly journals Adipose tissue immune cells in obesity, type 2 diabetes mellitus and cardiovascular diseases

2021 ◽  
Author(s):  
Anna Cinkajzlová ◽  
Milos Mraz ◽  
Martin Haluzik
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Adipose Tissue ◽  
Cardiovascular Diseases ◽  
Immune Cells ◽  
Immune Cell ◽  
Current Knowledge ◽  
Systemic Circulation

Immune cells are an inseparable component of adipose tissue intimately involved in most of its functions. Physiologically, they regulate adipose tissue homeostasis, while in case of adipose tissue stress immune cells are able to change their phenotype, enhance their count and subsequently contribute to the development and maintenance of local adipose tissue inflammation. Immune cells are an important source of inflammatory cytokines and other pro-inflammatory products that further influence not only surrounding tissues, but via systemic circulation also the whole organism being thus one of the main factors responsible for the transition from simple obesity to associated metabolic and cardiovascular complications. The purpose of this review is to summarize current knowledge on different adipose tissue immune cell subsets and their role in the development of obesity, type 2 diabetes mellitus and cardiovascular diseases.

scholarly journals Blockade of the CD93 pathway normalizes tumor vasculature to facilitate drug delivery and immunotherapy

2021 ◽  
Vol 13 (604) ◽  
pp. eabc8922
Author(s):  
Yi Sun ◽  
Wei Chen ◽  
Robert J. Torphy ◽  
Sheng Yao ◽  
Gefeng Zhu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Tumor Microenvironment ◽  
Immune Cell ◽  
Vascular Dysfunction ◽  
Tumor Hypoxia ◽  
Tumor Vasculature ◽  
Poor Response ◽  
Response To Therapy ◽  
Mouse Tumor ◽  
Programmed Death

The immature and dysfunctional vascular network within solid tumors poses a substantial obstacle to immunotherapy because it creates a hypoxic tumor microenvironment that actively limits immune cell infiltration. The molecular basis underpinning this vascular dysfunction is not fully understood. Using genome-scale receptor array technology, we showed here that insulin-like growth factor binding protein 7 (IGFBP7) interacts with its receptor CD93, and we subsequently demonstrated that this interaction contributes to abnormal tumor vasculature. Both CD93 and IGFBP7 were up-regulated in tumor-associated endothelial cells. IGFBP7 interacted with CD93 via a domain different from multimerin-2, the known ligand for CD93. In two mouse tumor models, blockade of the CD93/IGFBP7 interaction by monoclonal antibodies promoted vascular maturation to reduce leakage, leading to reduced tumor hypoxia and increased tumor perfusion. CD93 blockade in mice increased drug delivery, resulting in an improved antitumor response to gemcitabine or fluorouracil. Blockade of the CD93 pathway triggered a substantial increase in intratumoral effector T cells, thereby sensitizing mouse tumors to immune checkpoint therapy. Last, analysis of samples from patients with cancer under anti–programmed death 1/programmed death-ligand 1 treatment revealed that overexpression of the IGFBP7/CD93 pathway was associated with poor response to therapy. Thus, our study identified a molecular interaction involved in tumor vascular dysfunction and revealed an approach to promote a favorable tumor microenvironment for therapeutic intervention.

Safety assessment of a new nanoemulsion-based drug-delivery system reveals unexpected drug-free anticoagulant activity

Nanomedicine ◽  
2020 ◽  
Vol 15 (14) ◽  
pp. 1361-1373
Author(s):  
James J Hobson ◽  
Steve P Rannard ◽  
Andrew Owen ◽  
Neill J Liptrott
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Safety Assessment ◽  
Cell Function ◽  
Immune Cell ◽  
Anticoagulant Activity ◽  
Drug Free ◽  
Preclinical Safety

Aim: A preclinical safety assessment of a novel nanoemulsion drug-delivery system, initially developed to improve the posology of efavirenz (EFV), was conducted with a specific focus on possible immunological and hematological complications. Materials & methods: Assessment of common acute toxicities, such as complement activation and cytokine secretion, was performed using validated assays known to have good correlation with in vivo end points. Results & conclusion: Compared with a standard aqueous solution of EFV, the EFV nanoemulsion showed no significant effect on immune cell function or phenotype. Prolongation of activated partial thromboplastin time was observed for EFV-loaded nanoemulsions (88% at 4 μg/ml) as well as unloaded nanoemulsions (52%) highlighting the potential for drug-free anticoagulant activity and warranting further investigation of the mechanism and utility of these materials.

Prospective of Natural Gum Nanoparticulate Against Cardiovascular Disorders

2019 ◽  
Vol 13 (3) ◽  
pp. 197-211
Author(s):  
Aakash Deep ◽  
Neeraj Rani ◽  
Ashok Kumar ◽  
Rimmy Nandal ◽  
Prabodh C. Sharma ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cardiovascular Diseases ◽  
Drug Release ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Natural Polymers ◽  
Stabilizing Agents ◽  
Synthetic Materials ◽  
Materials Used ◽  
Cellular Components

Background: Objective: Various natural gums can be synergistically used in nanoparticulate drug delivery systems to treat cardiovascular diseases. Nanotechnology has been integrated into healthcare in terms of theranostics. In this review, we consider various natural gums that can be used for the preparation of nanoparticles and their role to treat cardiovascular disease. Methods: Nanoparticles can carry drugs at nanoscales and deliver them to the targeted sites with the desired pattern of drug release. They have specialized uptake mechanisms (e.g. - absorptive endocytosis) which improve the bioavailability of drugs. Results: By considering cardiovascular diseases at the molecular level, it is possible to modify the materials with nanotechnology and apply nano-formulations efficiently as compared with conventional preparations, due to the fact that the extracellular matrix (ECM) comprises components at the nanoscale range. The interactions of ECM components with cellular components occur at the nanoscale, therefore the nanomaterials have the potential to maintain the nanoscale properties of cells. The synthetic materials used to develop the nanoparticulate drug delivery system may cause toxicity. Conclusion: This problem can be overcome by using natural polymers. Natural gums can be used in nanoparticulate drug delivery systems as reducing and stabilizing agents and in some cases; they may directly or indirectly influence the rate of drug release and absorption from the preparation.

Sign in / Sign up

Export Citation Format

Share Document