scholarly journals A pH-Sensitive Prodrug Nanocarrier Based on Diosgenin for Doxorubicin Delivery to Efficiently Inhibit Tumor Metastasis

2020 ◽  
Vol Volume 15 ◽  
pp. 6545-6560 ◽  
Author(s):  
Zeliang Wei ◽  
Haibo Wang ◽  
Guang Xin ◽  
Zhi Zeng ◽  
Shiyi Li ◽  
...  
Keyword(s):  
Tumor Metastasis ◽  
Ph Sensitive ◽  
Doxorubicin Delivery ◽  
Inhibit Tumor Metastasis

Selenium nanoparticles inhibit tumor metastasis in prostate cancer through upregulated miR-155-5p-related pathway

2021 ◽  
Vol 85 (2) ◽  
pp. 287-296
Author(s):  
Guolong Liao ◽  
He Ma ◽  
Yamei Li ◽  
Yiyu Sheng ◽  
Chujie Chen
Keyword(s):  
Prostate Cancer ◽  
Tumor Metastasis ◽  
Selenium Nanoparticles ◽  
Migration And Invasion ◽  
Related Protein ◽  
Iκb Kinase ◽  
Antitumor Potential ◽  
Xenograft Mice ◽  
Inhibit Tumor Metastasis ◽  
Related Pathway

ABSTRACT Prostate cancer are the most common, malignant and lethal tumors in men, and the complexity of prostate cancer (CaP) is also due to the diverse metastasis profile. Selenium nanoparticles (SeNPs) have been reported to have potent antitumor activity, but whether it impacted the tumor metastasis is not fully clear. Here, we confirmed that SeNPs could inhibit the CaP cell migrations and invasions. Combined with our previous findings, we identified a series of microRNAs that could be upregulated significantly under SeNP treatment, among which miR-155-5p acts as a key component in mediating the SeNP-inhibited migration and invasion of CaP cells, through directly targeting IκB kinase ɛ and Sma- and Mad-related protein 2. The cell-based results were proved in xenograft mice modeling. These results have evidently signified the antitumor potential of SeNPs in the treatment of prostate cancer.

scholarly journals Development of a pH-responsive polymersome inducing endoplasmic reticulum stress and autophagy blockade

2020 ◽  
Vol 6 (31) ◽  
pp. eabb8725 ◽  
Author(s):  
Funeng Xu ◽  
Xilin Li ◽  
Xuehui Huang ◽  
Jingmei Pan ◽  
Yi Wang ◽  
...  
Keyword(s):  
Endoplasmic Reticulum ◽  
Er Stress ◽  
Tumor Metastasis ◽  
Focal Adhesions ◽  
Matrix Metalloproteinase 2 ◽  
Autophagic Flux ◽  
Ph Responsive ◽  
Ph Response ◽  
Function Mechanism ◽  
Inhibit Tumor Metastasis

Autophagy is involved in the occurrence and development of tumors. Here, a pH-responsive polymersome codelivering hydroxychloroquine (HCQ) and tunicamycin (Tuni) drugs is developed to simultaneously induce endoplasmic reticulum (ER) stress and autophagic flux blockade for achieving an antitumor effect and inhibiting tumor metastasis. The pH response of poly(β-amino ester) and HCQ synergistically deacidifies the lysosomes, thereby blocking the fusion of autophagosomes and lysosomes and lastly blocking autophagic flux. The function mechanism of regulating autophagy was systematically investigated on orthotopic luciferase gene–transfected, 4T1 tumor–bearing BALB/c mice through Western blot and immunohistochemistry analyses. The Tuni triggers ER stress to regulate the PERK/Akt signaling pathway to increase the autophagic level. The “autophagic stress” generated by triggering ER stress–induced autophagy and blocking autophagic flux is effective against tumors. The reduced expression of matrix metalloproteinase-2 due to ER stress and reduced focal adhesions turnover due to the blockade of autophagic flux synergistically inhibit tumor metastasis.

pH-sensitive deoxycholic acid dimer for improving doxorubicin delivery and antitumor activity in vivso

2020 ◽  
Vol 196 ◽  
pp. 111319
Author(s):  
Jiaxi Xu ◽  
Qin Fang ◽  
Longshun Yang ◽  
Jialu Gao ◽  
Yanbing Xue ◽  
...  
Keyword(s):  
Antitumor Activity ◽  
Deoxycholic Acid ◽  
Ph Sensitive ◽  
Doxorubicin Delivery

scholarly journals Bacteria-triggered tumor-specific thrombosis to enable potent photothermal immunotherapy of cancer

2020 ◽  
Vol 6 (33) ◽  
pp. eaba3546 ◽  
Author(s):  
Xuan Yi ◽  
Hailin Zhou ◽  
Yu Chao ◽  
Saisai Xiong ◽  
Jing Zhong ◽  
...  
Keyword(s):  
Immune Responses ◽  
Photothermal Therapy ◽  
Tumor Metastasis ◽  
Near Infrared ◽  
Photoacoustic Imaging ◽  
Immune Checkpoint Blockade ◽  
Immune Memory ◽  
Immunotherapy Of Cancer ◽  
Rapid Clearance ◽  
Inhibit Tumor Metastasis

We discovered that attenuated Salmonella after intravenous injection would proliferate within various types of solid tumors but show rapid clearance in normal organs, without rendering notable toxicity. Bacteria-induced inflammation would trigger thrombosis in the infected tumors by destroying tumor blood vessels. Six types of tested tumors would all turn into darkened color with strong near-infrared absorbance, as observed by photoacoustic imaging. Under laser irradiation, those bacterial-infected tumors would be effectively ablated. Because of the immune-stimulation function, such bacteria-based photothermal therapy (PTT) would subsequently trigger antitumor immune responses, which could be further enhanced by immune checkpoint blockade to effectively suppress the growth of abscopal tumors. A robust immune memory effect to reject rechallenged tumors is also observed after bacteria-based PTT. Our work demonstrates that bacteria by themselves could act as a tumor-specific PTT agent to enable photoimmunotherapy cancer therapy to inhibit tumor metastasis and recurrence.

Nitric oxide-releasing platinum(iv) prodrug efficiently inhibits proliferation and metastasis of cancer cells

2020 ◽  
Vol 56 (90) ◽  
pp. 14051-14054
Author(s):  
Yi Dai ◽  
Yang Zhu ◽  
Junjie Cheng ◽  
Juan Shen ◽  
Hai Huang ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Cancer Cells ◽  
Cell Apoptosis ◽  
Tumor Metastasis ◽  
Dual Function ◽  
Signaling Molecule ◽  
Proliferation And Metastasis ◽  
Induce Cell Apoptosis ◽  
Nitric Oxide Releasing ◽  
Inhibit Tumor Metastasis

Pt–furoxan, a nitric oxide-releasing platinum(iv) prodrug, exhibits a dual function by releasing cytotoxic cisplatin to induce cell apoptosis, and signaling molecule NO to inhibit tumor metastasis.

Dual thermo-and pH-sensitive injectable hydrogels of chitosan/(poly(N-isopropylacrylamide-co-itaconic acid)) for doxorubicin delivery in breast cancer

2019 ◽  
Vol 128 ◽  
pp. 957-964 ◽  
Author(s):  
Marziyeh Fathi ◽  
Mitra Alami-Milani ◽  
Mohammad Hossein Geranmayeh ◽  
Jaleh Barar ◽  
Hamid Erfan-Niya ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Itaconic Acid ◽  
Ph Sensitive ◽  
Injectable Hydrogels ◽  
Doxorubicin Delivery

Enhanced radiosensitization of ternary Cu3BiSe3 nanoparticles by photo-induced hyperthermia in the second near-infrared biological window

Nanoscale ◽  
2019 ◽  
Vol 11 (15) ◽  
pp. 7157-7165 ◽  
Author(s):  
Jiangfeng Du ◽  
Xin Wang ◽  
Xinghua Dong ◽  
Chenyang Zhang ◽  
Linqiang Mei ◽  
...  
Keyword(s):  
Tumor Metastasis ◽  
Near Infrared ◽  
X Ray ◽  
Induced Hyperthermia ◽  
Inhibit Tumor Metastasis ◽  
High Absorption

PVP-Cu3BiSe3 nanoparticles with strong X-ray attenuation ability and high absorption of NIR-II light could enhance radiothermotherapy and inhibit tumor metastasis.

scholarly journals Bovine Lactoferrin and Lactoferricin, a Peptide Derived from Bovine Lactoferrin, Inhibit Tumor Metastasis in Mice

1997 ◽  
Vol 88 (2) ◽  
pp. 184-190 ◽  
Author(s):  
Yung-Choon Yoo ◽  
Shikiko Watanabe ◽  
Ryosuke Watanabe ◽  
Katsusuke Hata ◽  
Kei-ichi Shimazaki ◽  
...  
Keyword(s):  
Tumor Metastasis ◽  
Bovine Lactoferrin ◽  
Inhibit Tumor Metastasis

Polysaccharides from ginseng leaves inhibit tumor metastasis via macrophage and NK cell activation

2017 ◽  
Vol 103 ◽  
pp. 1327-1333 ◽  
Author(s):  
Myoung-Sook Shin ◽  
Su-Hyun Hwang ◽  
Taek-Joon Yoon ◽  
Sung Han Kim ◽  
Kwang-Soon Shin
Keyword(s):  
Tumor Metastasis ◽  
Cell Activation ◽  
Nk Cell ◽  
Inhibit Tumor Metastasis
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