Nitric oxide-releasing platinum(iv) prodrug efficiently inhibits proliferation and metastasis of cancer cells

2020 ◽  
Vol 56 (90) ◽  
pp. 14051-14054
Author(s):  
Yi Dai ◽  
Yang Zhu ◽  
Junjie Cheng ◽  
Juan Shen ◽  
Hai Huang ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Cancer Cells ◽  
Cell Apoptosis ◽  
Tumor Metastasis ◽  
Dual Function ◽  
Signaling Molecule ◽  
Proliferation And Metastasis ◽  
Induce Cell Apoptosis ◽  
Nitric Oxide Releasing ◽  
Inhibit Tumor Metastasis

Pt–furoxan, a nitric oxide-releasing platinum(iv) prodrug, exhibits a dual function by releasing cytotoxic cisplatin to induce cell apoptosis, and signaling molecule NO to inhibit tumor metastasis.

scholarly journals Statins induce cell apoptosis through a modulation of AKT/FOXO1 pathway in prostate cancer cells

2019 ◽  
Vol Volume 11 ◽  
pp. 7231-7242 ◽  
Author(s):  
Jun-Li Deng ◽  
Rui Zhang ◽  
Ying Zeng ◽  
Yuan-Shan Zhu ◽  
Guo Wang
Keyword(s):  
Prostate Cancer ◽  
Cancer Cells ◽  
Cell Apoptosis ◽  
Prostate Cancer Cells ◽  
Induce Cell Apoptosis

808 nm-light-excited upconversion nanoprobe based on LRET for the ratiometric detection of nitric oxide in living cancer cells

Nanoscale ◽  
2018 ◽  
Vol 10 (22) ◽  
pp. 10641-10649 ◽  
Author(s):  
Han Wang ◽  
Yi Liu ◽  
Zhaohui Wang ◽  
Man Yang ◽  
Yueqing Gu
Keyword(s):  
Nitric Oxide ◽  
Tumor Cell ◽  
Cancer Cells ◽  
Cell Apoptosis ◽  
Tumor Cell Apoptosis ◽  
Low Concentrations ◽  
Ratiometric Detection ◽  
High Concentrations ◽  
Dual Functions

NO (nitric oxide) has dual functions in cancer, promoting carcinogenesis in low concentrations and inducing tumor cell apoptosis at high concentrations.

scholarly journals Nitric Oxide-Releasing Aspirin Suppresses NF-κB Signaling in Estrogen Receptor Negative Breast Cancer Cells in Vitro and in Vivo

Molecules ◽  
2015 ◽  
Vol 20 (7) ◽  
pp. 12481-12499 ◽  
Author(s):  
Niharika Nath ◽  
Mitali Chattopadhyay ◽  
Deborah Rodes ◽  
Anna Nazarenko ◽  
Ravinder Kodela ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Nitric Oxide ◽  
Estrogen Receptor ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Nitric Oxide Releasing ◽  
Estrogen Receptor Negative

scholarly journals AnnexinA5 Might Suppress the Phenotype of Human Gastric Cancer Cells via ERK Pathway

2021 ◽  
Vol 11 ◽  
Author(s):  
Xiaojie Wang ◽  
Yarui Dai ◽  
Yina Zhao ◽  
Meichuan Li ◽  
Jialu Zhang ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Cells ◽  
Cell Apoptosis ◽  
Signal Pathway ◽  
Human Gastric Cancer ◽  
Gastric Cancer Cells ◽  
Proliferation And Metastasis ◽  
Erk Signal Pathway ◽  
Apoptosis And Necrosis ◽  
Cell Proliferation And Metastasis

Gastric cancer is one of the most fatal diseases around the world. However, the mechanism of the development of gastric cancer is still not clarified. In addition, the anticancer drugs have cytotoxicity with different degrees. AnnexinA5, a member of the annexin family, has a great binding ability with the membrane phospholipid in a calcium dependent manner and is involved in the development of various cancers. This study aims to explore the influence of annexinA5 on human gastric cancer cells and whether it has the potential to be an auxiliary treatment to gastric cancer. In this study, the role of annexinA5 was detected from both the endogenous and the exogenous aspects on the gastric cancer cell lines MGC-803 and MKN-45. The cells were divided into a knockdown group in which RNA interference technique was used to suppress annexinA5 expression and a protein-supplementing group in which annexinA5 protein was added in the culture supernatant. After the suppression ratio of RNA interference was determined and the IC50 of annexinA5 protein was decided respectively, the cells’ proliferation was detected by MTT assay, colony formation assay, and the expression of PCNA. FCM assay and PI staining methods were applied to test cell apoptosis and necrosis. To investigate whether ANXA5 influence cell metastasis, wound healing assay and transwell assay were employed. To further detect the mechanism of annexinA5 action, the signal pathway was examined with Western Blot method. When ANXA5 gene was knocked down, cell proliferation and metastasis were promoted, while cell apoptosis was suppressed. On the other hand, after the annexinA5 protein was applied to the gastric cancer cells, cell proliferation and metastasis were inhibited, while cell apoptosis and necrosis were promoted. AnnexinA5 played its role via ERK signal pathway. ANXA5 acted as tumor suppressor gene in the gastric cancer by suppressing ERK signal pathway and has the potentiality to be an auxiliary anticancer agent.

Synthesis and biological evaluation of nitric oxide-releasing hybrids from gemcitabine and phenylsulfonyl furoxans as anti-tumor agents

MedChemComm ◽  
2015 ◽  
Vol 6 (6) ◽  
pp. 1130-1136 ◽  
Author(s):  
Xianghua Li ◽  
Xuemin Wang ◽  
Chenjun Xu ◽  
Junkai Huang ◽  
Chengniu Wang ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Tumor Cells ◽  
Biological Evaluation ◽  
Nucleoside Transporter ◽  
Antitumor Activities ◽  
Induce Cell Apoptosis ◽  
Nitric Oxide Releasing ◽  
Related Proteins ◽  
Synthesis And Biological Evaluation

Novel furoxan/gemcitabine hybrids displayed significant antitumor activities, in particular 10e, which could be independent of the nucleoside transporter, release high levels of NO, and induce cell apoptosis by regulating apoptotic related proteins in tumor cells in vitro.

Mitochondria-targeting cyclometalated iridium(iii) complexes for tumor hypoxic imaging and therapy

2019 ◽  
Vol 6 (4) ◽  
pp. 1003-1010 ◽  
Author(s):  
Jia Li ◽  
Hongmin Chen ◽  
Leli Zeng ◽  
Thomas W. Rees ◽  
Kai Xiong ◽  
...  
Keyword(s):  
Mitochondrial Dysfunction ◽  
Cancer Cells ◽  
Hela Cells ◽  
Cell Apoptosis ◽  
Caspase 3 ◽  
Turn On ◽  
Induce Cell Apoptosis ◽  
Theranostic Agents ◽  
Mitochondria Targeting

The organometallic anthraquinone iridium(iii) complexes display an efficient turn-on phosphorescence response to hypoxia. The complexes can induce cell apoptosis in HeLa cells via mitochondrial dysfunction and caspase-3 activation making them excellent candidates as theranostic agents for hypoxic cancer cells.

Combating metastasis of breast cancer cells with a carboplatin analogue containing an all-trans retinoic acid ligand

2020 ◽  
Vol 49 (16) ◽  
pp. 5039-5043
Author(s):  
Yi Dai ◽  
Hai Huang ◽  
Yang Zhu ◽  
Junjie Cheng ◽  
Ai-Zong Shen ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Retinoic Acid ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Tumor Metastasis ◽  
Click Reaction ◽  
Dual Function ◽  
Acid Ligand ◽  
Trans Retinoic Acid ◽  
All Trans Retinoic Acid

Pt-ATRA, a carboplatin analogue containing an all-trans retinoic acid (ATRA) derivative ligand, was synthesized via a click reaction. Pt-ATRA demonstrates dual function by inducing cell apoptosis and inhibiting tumor metastasis.

scholarly journals Long Noncoding RNA Urothelial Carcinoma-Associated 1 Promotes the Proliferation and Metastasis of Human Lung Tumor Cells by Regulating MicroRNA-144

2018 ◽  
Vol 26 (4) ◽  
pp. 537-546 ◽  
Author(s):  
Dagang Li ◽  
Huizong Li ◽  
Yuping Yang ◽  
Le Kang
Keyword(s):  
Lung Cancer ◽  
Cell Cycle ◽  
Cell Viability ◽  
Cancer Cells ◽  
A549 Cell ◽  
Cell Apoptosis ◽  
Long Noncoding Rna ◽  
Noncoding Rna ◽  
Human Lung ◽  
Proliferation And Metastasis

Long noncoding RNA urothelial carcinoma-associated 1 (lncRNA UCA1) has gained more attention in recent years due to its oncogenic roles in various cancers. MicroRNA-144 (miR-144) participates in the regulation of the growth of many cancer cells. This study investigated the interaction between lncRNA UCA1 and miR-144 in lung cancer cells. The potential downstream protein of miR-144 was also assessed. Our results found that lncRNA UCA1 was highly expressed in human lung cancer A549, H517, H4006, H1299, and H1650 cells compared to normal embryonic lung WI-38 and HEL-1 cells. Knockdown of lncRNA UCA1 significantly inhibited lung cancer A549 cell viability, migration, invasion, and cell cycle progression, but promoted cell apoptosis. Besides, we found that lncRNA UCA1 was bound to miR-144. miR-144 participated in the regulation effects of lncRNA UCA1 on A549 cell viability, migration, invasion, cell cycle transition, and cell apoptosis. In addition, Pre-B-cell leukemia homeobox 3 (PBX3) was found to be a direct target gene of miR-144. Overexpression of PBX3 promoted A549 cell proliferation and metastasis. Suppression of PBX3 had an opposite effect.

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