scholarly journals Magnetic And pH Dual-Responsive Nanoparticles For Synergistic Drug-Resistant Breast Cancer Chemo/Photodynamic Therapy

2019 ◽  
Vol Volume 14 ◽  
pp. 7665-7679 ◽  
Author(s):  
Dan Wang ◽  
Xuefen Li ◽  
Xinfang Li ◽  
Anfeng Kang ◽  
Linhong Sun ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Photodynamic Therapy ◽  
Drug Resistant ◽  
Dual Responsive

scholarly journals pH and redox dual-responsive nanoparticles based on disulfide-containing poly(β-amino ester) for combining chemotherapy and COX-2 inhibitor to overcome drug resistance in breast cancer

2019 ◽  
Vol 17 (1) ◽  
Author(s):  
Sipei Zhang ◽  
Nan Guo ◽  
Guoyun Wan ◽  
Tao Zhang ◽  
Chunyu Li ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Drug Resistance ◽  
Synergistic Effects ◽  
Chemotherapeutic Agents ◽  
Common Mechanism ◽  
Drug Resistant ◽  
Dual Responsive ◽  
Cox 2 ◽  
Mcf 7

Abstract Background Multidrug resistance (MDR) generally leads to breast cancer treatment failure. The most common mechanism of MDR is the overexpression of ATP-binding cassette (ABC) efflux transporters such as P-glycoprotein (P-gp) that reduce the intracellular accumulation of various chemotherapeutic agents. Celecoxib (CXB), a selective COX-2 inhibitor, can dramatically enhance the cytotoxicity of doxorubicin (DOX) in breast cancer cells overexpressing P-gp. Thus it can be seen that the combination of DOX and CXB maybe obtain synergistic effects against breast cancer by overcoming drug resistance. Results In this study, we designed a pH and redox dual-responsive nanocarrier system to combine synergistic effects of DOX and CXB against drug resistant breast cancer. This nanocarrier system denoted as HPPDC nanoparticles showed good in vitro stability and significantly accelerated drug releases under the acidic and redox conditions. In drug-resistant human breast cancer MCF-7/ADR cells, HPPDC nanoparticles significantly enhanced the cellular uptake of DOX through the endocytosis mediated by CD44/HA specific binding and the down-regulated P-gp expression induced by COX-2 inhibition, and thus notably increased the cytotoxicity and apoptosis-inducing activity of DOX. In MCF-7/ADR tumor-bearing nude mice, HPPDC nanoparticles showed excellent tumor-targeting ability, remarkably enhanced tumor chemosensitivity and reduced COX-2 and P-gp expressions in tumor tissues. Conclusion All results demonstrated that HPPDC nanoparticles can efficiently overcome drug resistance in breast cancer both in vitro and in vivo by combining chemotherapy and COX-2 inhibitor. In a summary, HPPDC nanoparticles show a great potential for combination treatment of drug resistant breast cancer.

Near-infrared light and magnetic field dual-responsive porous silicon-based nanocarriers to overcome multidrug resistance in breast cancer cells with enhanced efficiency

2020 ◽  
Vol 8 (3) ◽  
pp. 546-557 ◽  
Author(s):  
Jiachen Li ◽  
Weiwei Zhang ◽  
Yan Gao ◽  
Haibei Tong ◽  
Zhenyu Chen ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Magnetic Field ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Near Infrared ◽  
Drug Carriers ◽  
Infrared Light ◽  
Drug Resistant ◽  
Dual Responsive ◽  
Silicon Based

Magnetic and photothermal PSiNPs@(Fe3O4/Au) nanocomposites as anticancer drug carriers improved combined chemo-photothermal therapeutic efficacy of drug-resistant breast cancer cells.

Nanoceria-Mediated Drug Delivery for Targeted Photodynamic Therapy on Drug-Resistant Breast Cancer

2016 ◽  
Vol 8 (46) ◽  
pp. 31510-31523 ◽  
Author(s):  
Hong Li ◽  
Cong Liu ◽  
Yi-Ping Zeng ◽  
Yu-Hui Hao ◽  
Jia-Wei Huang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Drug Delivery ◽  
Photodynamic Therapy ◽  
Drug Resistant ◽  
Targeted Photodynamic Therapy

Photodynamic therapy activities of phthalocyanine-based macromolecular photosensitizers on MCF-7 breast cancer cells

2021 ◽  
pp. 1-10
Author(s):  
Erem Ahmetali ◽  
Pinar Sen ◽  
N. Ceren Süer ◽  
Tebello Nyokong ◽  
Tarik Eren ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Photodynamic Therapy ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Mcf 7

scholarly journals Biomimetic oxygen delivery nanoparticles for enhancing photodynamic therapy in triple-negative breast cancer

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Hanyi Fang ◽  
Yongkang Gai ◽  
Sheng Wang ◽  
Qingyao Liu ◽  
Xiao Zhang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Photodynamic Therapy ◽  
Cancer Cell ◽  
Triple Negative Breast Cancer ◽  
Oxygen Delivery ◽  
Therapeutic Efficacy ◽  
Triple Negative ◽  
Oxygen Solubility ◽  
Post Injection

Abstract Background Triple-negative breast cancer (TNBC) is a kind of aggressive breast cancer with a high rate of metastasis, poor overall survival time, and a low response to targeted therapies. To improve the therapeutic efficacy and overcome the drug resistance of TNBC treatments, here we developed the cancer cell membrane-coated oxygen delivery nanoprobe, CCm–HSA–ICG–PFTBA, which can improve the hypoxia at tumor sites and enhance the therapeutic efficacy of the photodynamic therapy (PDT), resulting in relieving the tumor growth in TNBC xenografts. Results The size of the CCm–HSA–ICG–PFTBA was 131.3 ± 1.08 nm. The in vitro 1O2 and ROS concentrations of the CCm–HSA–ICG–PFTBA group were both significantly higher than those of the other groups (P < 0.001). In vivo fluorescence imaging revealed that the best time window was at 24 h post-injection of the CCm–HSA–ICG–PFTBA. Both in vivo 18F-FMISO PET imaging and ex vivo immunofluorescence staining results exhibited that the tumor hypoxia was significantly improved at 24 h post-injection of the CCm–HSA–ICG–PFTBA. For in vivo PDT treatment, the tumor volume and weight of the CCm–HSA–ICG–PFTBA with NIR group were both the smallest among all the groups and significantly decreased compared to the untreated group (P < 0.01). No obvious biotoxicity was observed by the injection of CCm–HSA–ICG–PFTBA till 14 days. Conclusions By using the high oxygen solubility of perfluorocarbon (PFC) and the homologous targeting ability of cancer cell membranes, CCm–HSA–ICG–PFTBA can target tumor tissues, mitigate the hypoxia of the tumor microenvironment, and enhance the PDT efficacy in TNBC xenografts. Furthermore, the HSA, ICG, and PFC are all FDA-approved materials, which render the nanoparticles highly biocompatible and enhance the potential for clinical translation in the treatment of TNBC patients.

Influence of the calmodulin antagonist EBB on cyclin B1 and Cdc2-p34 in human drug-resistant breast cancer MCF-7/ADR cells

2008 ◽  
Vol 5 (2) ◽  
pp. 108-112 ◽  
Author(s):  
Xu Shi ◽  
Yanhong Cheng ◽  
Linglin Zou ◽  
Dongsheng Xiong ◽  
Yuan Zhou ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cyclin B1 ◽  
Drug Resistant ◽  
Calmodulin Antagonist ◽  
Mcf 7
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