Nanoceria-Mediated Drug Delivery for Targeted Photodynamic Therapy on Drug-Resistant Breast Cancer

2016 ◽  
Vol 8 (46) ◽  
pp. 31510-31523 ◽  
Author(s):  
Hong Li ◽  
Cong Liu ◽  
Yi-Ping Zeng ◽  
Yu-Hui Hao ◽  
Jia-Wei Huang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Drug Delivery ◽  
Photodynamic Therapy ◽  
Drug Resistant ◽  
Targeted Photodynamic Therapy

scholarly journals Polymeric Encapsulation of a Ru(II)-based Photosensitizer for Folate Targeted Photodynamic Therapy of Drug Resistant Cancers

2020 ◽  
Author(s):  
Johannes Karges ◽  
Mickaël Tharaud ◽  
Gilles Gasser
Keyword(s):  
Drug Delivery ◽  
Photodynamic Therapy ◽  
Side Effects ◽  
Drug Delivery Systems ◽  
High Selectivity ◽  
Drug Resistant ◽  
Multicellular Tumor Spheroids ◽  
Targeted Photodynamic Therapy ◽  
Polymeric Encapsulation ◽  
Cancerous Cells

<p>The currently used photodynamic therapy (PDT) photosensitizers (PSs) are generally associated with a poor cancer cell selectivity, which is responsible for some undesirable side effects. To overcome these problems, the use of selective drug delivery systems is currently envisioned. In this article, the encapsulation of a promising Ru(II) polypyridine complex-based PDT PS in a polymer with terminal folate groups to form nanoparticles is presented. While showing a high selectivity for cancerous cells over non-cancerous cells, the nanoparticles were found to be highly phototoxic in 2D monolayer cells as well as 3D multicellular tumor spheroids upon 480 nm or 595 nm irradiation. Promisingly, the nanoparticles were also active in drug resistant cancer cells lines, indicating that they are able to overcome drug resistances. <br></p>

scholarly journals Polymeric Encapsulation of a Ru(II)-based Photosensitizer for Folate Targeted Photodynamic Therapy of Drug Resistant Cancers

2020 ◽  
Author(s):  
Johannes Karges ◽  
Mickaël Tharaud ◽  
Gilles Gasser
Keyword(s):  
Drug Delivery ◽  
Photodynamic Therapy ◽  
Side Effects ◽  
Drug Delivery Systems ◽  
High Selectivity ◽  
Drug Resistant ◽  
Multicellular Tumor Spheroids ◽  
Targeted Photodynamic Therapy ◽  
Polymeric Encapsulation ◽  
Cancerous Cells

<p>The currently used photodynamic therapy (PDT) photosensitizers (PSs) are generally associated with a poor cancer cell selectivity, which is responsible for some undesirable side effects. To overcome these problems, the use of selective drug delivery systems is currently envisioned. In this article, the encapsulation of a promising Ru(II) polypyridine complex-based PDT PS in a polymer with terminal folate groups to form nanoparticles is presented. While showing a high selectivity for cancerous cells over non-cancerous cells, the nanoparticles were found to be highly phototoxic in 2D monolayer cells as well as 3D multicellular tumor spheroids upon 480 nm or 595 nm irradiation. Promisingly, the nanoparticles were also active in drug resistant cancer cells lines, indicating that they are able to overcome drug resistances. <br></p>

scholarly journals Magnetic And pH Dual-Responsive Nanoparticles For Synergistic Drug-Resistant Breast Cancer Chemo/Photodynamic Therapy

2019 ◽  
Vol Volume 14 ◽  
pp. 7665-7679 ◽  
Author(s):  
Dan Wang ◽  
Xuefen Li ◽  
Xinfang Li ◽  
Anfeng Kang ◽  
Linhong Sun ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Photodynamic Therapy ◽  
Drug Resistant ◽  
Dual Responsive

scholarly journals Programmable Ce6 Delivery via Cyclopamine Based Tumor Microenvironment Modulating Nano-System for Enhanced Photodynamic Therapy in Breast Cancer

2019 ◽  
Vol 7 ◽  
Author(s):  
Chan Feng ◽  
Lv Chen ◽  
Yonglin Lu ◽  
Jie Liu ◽  
Shujing Liang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Drug Delivery ◽  
Photodynamic Therapy ◽  
Tumor Microenvironment ◽  
Cancer Cell Line ◽  
Chlorin E6 ◽  
Great Promise ◽  
Tissue Destruction ◽  
Mice Model ◽  
Cell Internalization

Photodynamic therapy (PDT) has shown great promise in breast cancer treatment. However, simplex target ligand modification or stimuli release cannot meet the requirement of effective drug delivery to solid tumor tissue. To overcome continuous bio-barriers existing in the tumor microenvironment, multi-stage response drug delivery was desirable. Herein, we developed a unique tumor microenvironment tailored nanoplatform for chlorin e6 (Ce6) delivery. We chose bovine serum albumin (BSA) as “mother ships” material for effective tumor periphery resident, cyclopamine (CYC) as extracellular matrix (ECM) inhibitor and synergistic anti-tumor agent, and diselenide containing amphiphilic hyaluronic acid-chlorin e6 polymers (HA-SeSe-Ce6) synthesized as “small bombs” for internal tissue destruction. The above three distinct function compositions were integrated into an independent CYC and HA-SeSe-Ce6 co-delivery albumin nano-system (ABN@HA-SeSe-Ce6/CYC). The obtained nano-system presents good biocompatible, long circulation and effective tumor accumulation. After entering tumor microenvironment, CYC gradually releases to disrupt the ECM barrier to open the way for further penetration of HA-SeSe-Ce6. Subsequently, targeted tumor cell internalization and intracellular redox response release of Ce6 would achieve. Moreover, CYC could also make up the deficiency of Ce6 in hypoxia area, owing to its anti-tumor effect. Improved therapeutic efficacy was verified in a breast cancer cell line and tumor-bearing mice model.

scholarly journals Biocompatible Nanocarriers for Enhanced Cancer Photodynamic Therapy Applications

Pharmaceutics ◽  
2021 ◽  
Vol 13 (11) ◽  
pp. 1933
Author(s):  
Sathish Sundar Dhilip Kumar ◽  
Heidi Abrahamse
Keyword(s):  
Drug Delivery ◽  
Photodynamic Therapy ◽  
Cancer Treatment ◽  
Targeting Therapy ◽  
Potential Applications ◽  
Carrier Molecule ◽  
Novel Material ◽  
Potential Benefits ◽  
Targeted Photodynamic Therapy

In recent years, the role of nanotechnology in drug delivery has become increasingly important, and this field of research holds many potential benefits for cancer treatment, particularly, in achieving cancer cell targeting and reducing the side effects of anticancer drugs. Biocompatible and biodegradable properties have been essential for using a novel material as a carrier molecule in drug delivery applications. Biocompatible nanocarriers are easy to synthesize, and their surface chemistry often enables them to load different types of photosensitizers (PS) to use targeted photodynamic therapy (PDT) for cancer treatment. This review article explores recent studies on the use of different biocompatible nanocarriers, their potential applications in PDT, including PS-loaded biocompatible nanocarriers, and the effective targeting therapy of PS-loaded biocompatible nanocarriers in PDT for cancer treatment. Furthermore, the review briefly recaps the global clinical trials of PDT and its applications in cancer treatment.

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