scholarly journals Mitoxantrone-preloaded water-responsive phospholipid-amorphous calcium carbonate hybrid nanoparticles for targeted and effective cancer therapy

2019 ◽  
Vol Volume 14 ◽  
pp. 1503-1517 ◽  
Author(s):  
Cheng Wang ◽  
Min Han ◽  
Xuerong Liu ◽  
Shaoqing Chen ◽  
Fuqiang Hu ◽  
...  
Keyword(s):  
Calcium Carbonate ◽  
Cancer Therapy ◽  
Hybrid Nanoparticles ◽  
Amorphous Calcium Carbonate ◽  
Effective Cancer Therapy

scholarly journals Correction: Facile preparation of phospholipid–amorphous calcium carbonate hybrid nanoparticles: toward controllable burst drug release and enhanced tumor penetration

2020 ◽  
Vol 56 (73) ◽  
pp. 10768-10769
Author(s):  
Cheng Wang ◽  
Xuerong Liu ◽  
Shaoqing Chen ◽  
Fuqiang Hu ◽  
Jihong Sun ◽  
...  
Keyword(s):  
Calcium Carbonate ◽  
Drug Release ◽  
Hybrid Nanoparticles ◽  
Amorphous Calcium Carbonate ◽  
Tumor Penetration ◽  
Facile Preparation

Correction for ‘Facile preparation of phospholipid–amorphous calcium carbonate hybrid nanoparticles: toward controllable burst drug release and enhanced tumor penetration’ by Cheng Wang et al., Chem. Commun., 2018, 54, 13080–13083, DOI: 10.1039/C8CC07694D.

Facile preparation of phospholipid–amorphous calcium carbonate hybrid nanoparticles: toward controllable burst drug release and enhanced tumor penetration

2018 ◽  
Vol 54 (93) ◽  
pp. 13080-13083 ◽  
Author(s):  
Cheng Wang ◽  
Xuerong Liu ◽  
Shaoqing Chen ◽  
Fuqiang Hu ◽  
Jihong Sun ◽  
...  
Keyword(s):  
Calcium Carbonate ◽  
Drug Release ◽  
Hybrid System ◽  
Hybrid Nanoparticles ◽  
Drug Penetration ◽  
Amorphous Calcium Carbonate ◽  
Tumor Penetration ◽  
Tumor Tissues ◽  
Facile Preparation

A hybrid system able to specifically realize water-responsive burst drug release and potentiate drug penetration into deep tumor tissues has been developed.

scholarly journals EGFR-mutant NSCLC presenting with stroke and massive systemic embolization as the first manifestation: case report

BMC Neurology ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Zheng Wang ◽  
Jiangyong Miao ◽  
Lina Wang ◽  
Ying Liu ◽  
Hui Ji ◽  
...  
Keyword(s):  
Risk Factors ◽  
Ischemic Stroke ◽  
Cancer Therapy ◽  
Acute Ischemic Stroke ◽  
Oral Anticoagulants ◽  
Initial Manifestation ◽  
Arterial Thromboembolism ◽  
Systemic Embolization ◽  
Effective Cancer Therapy

Abstract Background Presentation with massive systemic embolization as the initial manifestation of occult malignancy is infrequent. The standard management of cancer-related arterial thromboembolism has not yet been established. Case presentation We described a case of Trousseau’s syndrome resulting in acute ischemic stroke concomitant with multiple embolizations in the spleen and kidney during oral administration of dabigatran for pulmonary embolism preceding the diagnosis of a malignant tumor. A cancer-related hypercoagulable state was suspected because the patient was admitted to the neurology department due to acute ischemic stroke with three territory infarcts on diffusion-weighted imaging (DWI) in the absence of identifiable conventional risk factors and brain vessel narrowing. The patient was subsequently diagnosed with epidermal growth factor receptor (EGFR) mutation–positive non-small-cell lung cancer (NSCLC) (stage IV) with pleural metastasis. Administration of low-molecular-weight heparin followed by long-term dabigatran under effective cancer therapy comprising gefitinib and subsequent chemotherapy did not cause stroke relapse during the 1-year follow-up. Conclusions This case suggests that cancer-related hypercoagulability should be considered an important etiology for stroke patients who develop unexplained disseminated acute cerebral infarction without conventional stroke risk factors, especially concomitant with multiple organ embolization. Novel oral anticoagulants may be an alternative therapy for the long-term management of cancer-related arterial thromboembolism under effective cancer therapy.

scholarly journals Pure hydroxyapatite synthesis originating from amorphous calcium carbonate

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Michika Sawada ◽  
Kandi Sridhar ◽  
Yasuharu Kanda ◽  
Shinya Yamanaka
Keyword(s):  
Calcium Carbonate ◽  
Calcium Phosphate ◽  
Room Temperature ◽  
Molar Ratio ◽  
Final Phase ◽  
Amorphous Calcium Carbonate ◽  
Phosphate Compound ◽  
Synthesis Strategy ◽  
Phosphorylation Reaction ◽  
Subsequent Calcination

AbstractWe report a synthesis strategy for pure hydroxyapatite (HAp) using an amorphous calcium carbonate (ACC) colloid as the starting source. Room-temperature phosphorylation and subsequent calcination produce pure HAp via intermediate amorphous calcium phosphate (ACP). The pre-calcined sample undergoes a competitive transformation from ACC to ACP and crystalline calcium carbonate. The water content, ACC concentration, Ca/P molar ratio, and pH during the phosphorylation reaction play crucial roles in the final phase of the crystalline phosphate compound. Pure HAp is formed after ACP is transformed from ACC at a low concentration (1 wt%) of ACC colloid (1.71 < Ca/P < 1.88), whereas Ca/P = 1.51 leads to pure β-tricalcium phosphate. The ACP phases are precursors for calcium phosphate compounds and may determine the final crystalline phase.

scholarly journals On the Relation of Amorphous Calcium Carbonate and the Macromechanical Properties of Sea Urchin Spines

2020 ◽  
Vol 22 (4) ◽  
pp. 1900922 ◽  
Author(s):  
Christoph Lauer ◽  
Sebastian Haußmann ◽  
Patrick Schmidt ◽  
Carolin Fischer ◽  
Doreen Rapp ◽  
...  
Keyword(s):  
Calcium Carbonate ◽  
Sea Urchin ◽  
Amorphous Calcium Carbonate ◽  
Sea Urchin Spines

scholarly journals Transformation mechanism of amorphous calcium carbonate into calcite in the sea urchin larval spicule

2008 ◽  
Vol 105 (45) ◽  
pp. 17362-17366 ◽  
Author(s):  
Y. Politi ◽  
R. A. Metzler ◽  
M. Abrecht ◽  
B. Gilbert ◽  
F. H. Wilt ◽  
...  
Keyword(s):  
Calcium Carbonate ◽  
Sea Urchin ◽  
Amorphous Calcium Carbonate ◽  
Transformation Mechanism

scholarly journals Amorphous calcium carbonate transforms into calcite during sea urchin larval spicule growth

1997 ◽  
Vol 264 (1380) ◽  
pp. 461-465 ◽  
Author(s):  
Elia Beniash ◽  
Joanna Aizenberg ◽  
Lia Addadi ◽  
Stephen Weiner
Keyword(s):  
Calcium Carbonate ◽  
Sea Urchin ◽  
Amorphous Calcium Carbonate

scholarly journals Transformable Peptide Nanocarriers for Expeditious Drug Release and Effective Cancer Therapy via Cancer-Associated Fibroblast Activation

2015 ◽  
Vol 128 (3) ◽  
pp. 1062-1067 ◽  
Author(s):  
Tianjiao Ji ◽  
Ying Zhao ◽  
Yanping Ding ◽  
Jing Wang ◽  
Ruifang Zhao ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Drug Release ◽  
Fibroblast Activation ◽  
Cancer Associated Fibroblast ◽  
Effective Cancer Therapy
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