scholarly journals Effects of core size and PEG coating layer of iron oxide nanoparticles on the distribution and metabolism in mice

2018 ◽  
Vol Volume 13 ◽  
pp. 5719-5731 ◽  
Author(s):  
Weiming Xue ◽  
Yanyan Liu ◽  
Na Zhang ◽  
Youdong Yao ◽  
Pei Ma ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Coating Layer ◽  
Oxide Nanoparticles ◽  
Core Size ◽  
Peg Coating

scholarly journals Multifunctional superparamagnetic iron oxide nanoparticles for combined chemotherapy and hyperthermia cancer treatment

Nanoscale ◽  
2015 ◽  
Vol 7 (29) ◽  
pp. 12728-12736 ◽  
Author(s):  
Christopher A. Quinto ◽  
Priya Mohindra ◽  
Sheng Tong ◽  
Gang Bao
Keyword(s):  
Iron Oxide ◽  
Cancer Treatment ◽  
Iron Oxide Nanoparticles ◽  
Heat Generation ◽  
Superparamagnetic Iron Oxide ◽  
Superparamagnetic Iron Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Combined Chemotherapy ◽  
Peg Coating

Superparamagnetic iron oxide nanoparticles optimized with a phospholipid-PEG coating achieve high Doxorubicin loading and heat generation for an enhanced multimodal cancer treatment.

Dextran and PEG Coating Reduced Nanoparticle Toxicity to Cells

2012 ◽  
Author(s):  
Miao Yu ◽  
Alisa Morss Clyne
Keyword(s):  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Cell Mechanics ◽  
Surface Coating ◽  
Biomedical Applications ◽  
Oxide Nanoparticles ◽  
Oxygen Species ◽  
Cell Toxicity ◽  
Peg Coating

Iron oxide nanoparticles are of interest for drug delivery, since they can be targeted using a magnetic field. However, prior to using nanoparticles in vivo, they must be shown as relatively non-toxic to cells. We and others have shown that bare iron oxide nanoparticles are readily taken up by cells, where they catalyze production of highly toxic reactive oxygen species (ROS). This oxidative stress disrupts the cell cytoskeleton and alters cell mechanics. [1] Iron oxide nanoparticles under current development for in vivo biomedical applications are often coated with a polysaccharide (eg. dextran) or a polymer (eg. polyethylene glycol, PEG). Both the size and the surface coating of nanoparticle may play an important role in cell toxicity.

scholarly journals Albumin-Coated Single-Core Iron Oxide Nanoparticles for Enhanced Molecular Magnetic Imaging (MRI/MPI)

2021 ◽  
Vol 22 (12) ◽  
pp. 6235
Author(s):  
Abdulkader Baki ◽  
Amani Remmo ◽  
Norbert Löwa ◽  
Frank Wiekhorst ◽  
Regina Bleul
Keyword(s):  
Iron Oxide ◽  
Magnetic Resonance ◽  
Contrast Agents ◽  
Iron Oxide Nanoparticles ◽  
Magnetic Particle ◽  
Colloidal Stability ◽  
Simple Procedure ◽  
Oxide Nanoparticles ◽  
Core Size ◽  
Magnetic Iron Oxide Nanoparticles

Colloidal stability of magnetic iron oxide nanoparticles (MNP) in physiological environments is crucial for their (bio)medical application. MNP are potential contrast agents for different imaging modalities such as magnetic resonance imaging (MRI) and magnetic particle imaging (MPI). Applied as a hybrid method (MRI/MPI), these are valuable tools for molecular imaging. Continuously synthesized and in-situ stabilized single-core MNP were further modified by albumin coating. Synthesizing and coating of MNP were carried out in aqueous media without using any organic solvent in a simple procedure. The additional steric stabilization with the biocompatible protein, namely bovine serum albumin (BSA), led to potential contrast agents suitable for multimodal (MRI/MPI) imaging. The colloidal stability of BSA-coated MNP was investigated in different sodium chloride concentrations (50 to 150 mM) in short- and long-term incubation (from two hours to one week) using physiochemical characterization techniques such as transmission electron microscopy (TEM) for core size and differential centrifugal sedimentation (DCS) for hydrodynamic size. Magnetic characterization such as magnetic particle spectroscopy (MPS) and nuclear magnetic resonance (NMR) measurements confirmed the successful surface modification as well as exceptional colloidal stability of the relatively large single-core MNP. For comparison, two commercially available MNP systems were investigated, MNP-clusters, the former liver contrast agent (Resovist), and single-core MNP (SHP-30) manufactured by thermal decomposition. The tailored core size, colloidal stability in a physiological environment, and magnetic performance of our MNP indicate their ability to be used as molecular magnetic contrast agents for MPI and MRI.

Optimizing the alginate coating layer of doxorubicin-loaded iron oxide nanoparticles for cancer hyperthermia and chemotherapy

2018 ◽  
Vol 53 (19) ◽  
pp. 13826-13842 ◽  
Author(s):  
Thi Thu Huong Le ◽  
Thuc Quang Bui ◽  
Thi Minh Thi Ha ◽  
Mai Huong Le ◽  
Hong Nam Pham ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Coating Layer ◽  
Oxide Nanoparticles ◽  
Cancer Hyperthermia ◽  
Alginate Coating

scholarly journals Heparin length in the coating of extremely small iron oxide nanoparticles regulates in vivo theranostic applications

Nanoscale ◽  
2021 ◽  
Author(s):  
Hugo Groult ◽  
Susana Carregal-Romero ◽  
David Castejón ◽  
Mikel Azkargorta ◽  
Ana-Beatriz Miguel-Coello ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Core Size ◽  
Mri Contrast ◽  
Pharmacokinetic Properties ◽  
Theranostic Applications ◽  
Heparin Oligosaccharides

The length of heparin oligosaccharides in the coating of extremely small iron oxide nanoparticles can control core size during synthesis for optimal positive MRI contrast, endow probes with specific bioactivities and majorly impact the in vivo pharmacokinetic properties.

TARGETING CYCLIN B1 WITH ANTISENSE OLIGONUCLETOTIDES- COATED SUPERPARAMAGNETIC IRON OXIDE NANOPARTICLES

2018 ◽  
Vol 6 (10) ◽  
Author(s):  
Hosam Zaghloul ◽  
Doaa A. Shahin ◽  
Ibrahim El- Dosoky ◽  
Mahmoud E. El-awady ◽  
Fardous F. El-Senduny ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Cellular Uptake ◽  
Superparamagnetic Iron Oxide ◽  
Cyclin B1 ◽  
Superparamagnetic Iron Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Mcf7 Cells ◽  
M Phase ◽  
The Impact

Antisense oligonucleotides (ASO) represent an attractive trend as specific targeting molecules but sustain poor cellular uptake meanwhile superparamagnetic iron oxide nanoparticles (SPIONs) offer stability of ASO and improved cellular uptake. In the present work we aimed to functionalize SPIONs with ASO targeting the mRNA of Cyclin B1 which represents a potential cancer target and to explore its anticancer activity. For that purpose, four different SPIONs-ASO conjugates, S-M (1–4), were designated depending on the sequence of ASO and constructed by crosslinking carboxylated SPIONs to amino labeled ASO. The impact of S-M (1–4) on the level of Cyclin B1, cell cycle, ROS and viability of the cells were assessed by flowcytometry. The results showed that S-M3 and S-M4 reduced the level of Cyclin B1 by 35 and 36%, respectively. As a consequence to downregulation of Cyclin B1, MCF7 cells were shown to be arrested at G2/M phase (60.7%). S-M (1–4) led to the induction of ROS formation in comparison to the untreated control cells. Furthermore, S-M (1–4) resulted in an increase in dead cells compared to the untreated cells and SPIONs-treated cells. In conclusion, targeting Cyclin B1 with ASO-coated SPIONs may represent a specific biocompatible anticancer strategy.

Ferrozine Assay for Simple and Cheap Iron Analysis of Silica-Coated Iron Oxide Nanoparticles

2018 ◽  
Author(s):  
Hattie Ring ◽  
Zhe Gao ◽  
Nathan D. Klein ◽  
Michael Garwood ◽  
John C. Bischof ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Hydrofluoric Acid ◽  
Inductively Coupled Plasma ◽  
Silica Shell ◽  
Oxide Nanoparticles ◽  
Inductively Coupled ◽  
Digestion Process ◽  
Plasma Methods ◽  
Iron Analysis

The Ferrozinen assay is applied as an accurate and rapid method to quantify the iron content of iron oxide nanoparticles (IONPs) and can be used in biological matrices. The addition of ascorbic aqcid accelerates the digestion process and can penetrate an IONP core within a mesoporous and solid silica shell. This new digestion protocol avoids the need for hydrofluoric acid to digest the surrounding silica shell and provides and accessible alternative to inductively coupled plasma methods. With the updated digestion protocol, the quantitative range of the Ferrozine assay is 1 - 14 ppm. <br>

Sign in / Sign up

Export Citation Format

Share Document