scholarly journals Albumin-Coated Single-Core Iron Oxide Nanoparticles for Enhanced Molecular Magnetic Imaging (MRI/MPI)

2021 ◽  
Vol 22 (12) ◽  
pp. 6235
Author(s):  
Abdulkader Baki ◽  
Amani Remmo ◽  
Norbert Löwa ◽  
Frank Wiekhorst ◽  
Regina Bleul
Keyword(s):  
Iron Oxide ◽  
Magnetic Resonance ◽  
Contrast Agents ◽  
Iron Oxide Nanoparticles ◽  
Magnetic Particle ◽  
Colloidal Stability ◽  
Simple Procedure ◽  
Oxide Nanoparticles ◽  
Core Size ◽  
Magnetic Iron Oxide Nanoparticles

Colloidal stability of magnetic iron oxide nanoparticles (MNP) in physiological environments is crucial for their (bio)medical application. MNP are potential contrast agents for different imaging modalities such as magnetic resonance imaging (MRI) and magnetic particle imaging (MPI). Applied as a hybrid method (MRI/MPI), these are valuable tools for molecular imaging. Continuously synthesized and in-situ stabilized single-core MNP were further modified by albumin coating. Synthesizing and coating of MNP were carried out in aqueous media without using any organic solvent in a simple procedure. The additional steric stabilization with the biocompatible protein, namely bovine serum albumin (BSA), led to potential contrast agents suitable for multimodal (MRI/MPI) imaging. The colloidal stability of BSA-coated MNP was investigated in different sodium chloride concentrations (50 to 150 mM) in short- and long-term incubation (from two hours to one week) using physiochemical characterization techniques such as transmission electron microscopy (TEM) for core size and differential centrifugal sedimentation (DCS) for hydrodynamic size. Magnetic characterization such as magnetic particle spectroscopy (MPS) and nuclear magnetic resonance (NMR) measurements confirmed the successful surface modification as well as exceptional colloidal stability of the relatively large single-core MNP. For comparison, two commercially available MNP systems were investigated, MNP-clusters, the former liver contrast agent (Resovist), and single-core MNP (SHP-30) manufactured by thermal decomposition. The tailored core size, colloidal stability in a physiological environment, and magnetic performance of our MNP indicate their ability to be used as molecular magnetic contrast agents for MPI and MRI.

Magnetic iron oxide nanoparticles asT1contrast agents for magnetic resonance imaging

2018 ◽  
Vol 6 (6) ◽  
pp. 1280-1290 ◽  
Author(s):  
Y. Bao ◽  
J. A. Sherwood ◽  
Z. Sun
Keyword(s):  
Magnetic Resonance Imaging ◽  
Iron Oxide ◽  
Magnetic Nanoparticles ◽  
Magnetic Resonance ◽  
Contrast Agents ◽  
Iron Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Resonance Imaging ◽  
Magnetic Iron Oxide Nanoparticles ◽  
Synthesis Parameters

This review discusses several aspects regarding ultrasmall magnetic nanoparticles asT1contrast agents, including synthesis, parameters affectingT1, and applications.

Magnetic Iron Oxide Nanoparticles as Contrast Agents: Hydrothermal Synthesis, Characterization and Properties

2015 ◽  
Vol 232 ◽  
pp. 111-145 ◽  
Author(s):  
Tokeer Ahmad ◽  
Ruby Phul
Keyword(s):  
Magnetic Properties ◽  
Surface Modification ◽  
Iron Oxide ◽  
Hydrothermal Synthesis ◽  
Contrast Agents ◽  
Iron Oxide Nanoparticles ◽  
Surface Coating ◽  
Colloidal Stability ◽  
Oxide Nanoparticles ◽  
Magnetic Iron Oxide Nanoparticles

Superparamagnetic Iron oxide nanoparticles (SPIONs) have fascinated researchers due to their vast applications in biomedical fields such as magnetic resonance imaging, cell sorting, hyperthermia, drug delivery etc. The special properties of SPIONs depend on the method of synthesis and surface modification. Among various synthetic protocols, hydrothermal method has attracted much attention due to simplicity, uniformity and excellent magnetic properties of iron oxide nanoparticles. Magnetic properties of SPIONs could be tuned by controlling the size and shape of the particles as well as by the surface modification. Low colloidal stability and high hydrophobic nature of SPIONs result in aggregation of the particles which could be avoided by surface modification of the SPIONs using various capping agents. The size, shape and surface environment of SPIONs can also be controlled by the surface coating. SPIONs are promising contrast agents due to their non-poisonous nature, biocompatibility and large surface area. The biocompatibility of SPIONs is enhanced by the surface coating/modification. The present review focuses on the hydrothermal synthesis of SPIONs and their characterization using various techniques and the applications of SPIONs in the MRI.Table of Contents

scholarly journals The Effect of Surface Coating of Iron Oxide Nanoparticles on Magnetic Resonance Imaging Relaxivity

2021 ◽  
Vol 3 ◽  
Author(s):  
Fatemeh Ahmadpoor ◽  
Atif Masood ◽  
Neus Feliu ◽  
Wolfgang J. Parak ◽  
Seyed Abbas Shojaosadati
Keyword(s):  
Magnetic Resonance Imaging ◽  
Iron Oxide ◽  
Magnetic Resonance ◽  
Contrast Agents ◽  
Iron Oxide Nanoparticles ◽  
Surface Coating ◽  
Colloidal Stability ◽  
Oxide Nanoparticles ◽  
Resonance Imaging ◽  
Ligand Shell

Iron oxide nanoparticles (IONPs) with acceptable biocompatibility and size-dependent magnetic properties can be used as efficient contrast agents in magnetic resonance imaging (MRI). Herein, we have investigated the impact of particle size and surface coating on the proton relaxivity of IONPs, as well as engineering of small IONPs' surface coating as a strategy for achieving gadolinium-free contrast agents. Accordingly, polymer coating using poly(isobutylene-alt-maleic anhydride) (PMA) with overcoating of the original ligands was applied for providing colloidal stability to originally oleic acid–capped IONPs in aqueous solution. In case of replacement of the original ligand shell, the polymer had been modified with dopamine. Furthermore, the colloidal stability of the polymer-coated IONPs was evaluated in NaCl and bovine serum albumin (BSA) solutions. The results indicate that the polymer-coated IONPs which involved replacement of the original ligands exhibited considerably better colloidal stability and higher proton relaxivity in comparison to polymer-coated IONPs with maintained ligand shell. The highest r2/r1 we obtained was around 300.

The Evolution of Iron Oxide Nanoparticles as MRI Contrast Agents

MRS Advances ◽  
2020 ◽  
Vol 5 (42) ◽  
pp. 2157-2168
Author(s):  
Aileen O'Shea ◽  
Anushri Parakh ◽  
Rita Maria Lahoud ◽  
Sandeep Hedgire ◽  
Mukesh G Harisinghani
Keyword(s):  
Iron Oxide ◽  
Magnetic Resonance ◽  
Contrast Agents ◽  
Iron Oxide Nanoparticles ◽  
Imaging Techniques ◽  
Mri Contrast Agents ◽  
Oxide Nanoparticles ◽  
Clinical Imaging ◽  
Iron Storage ◽  
Inflammatory Conditions

AbstractWhile the use of iron oxide nanoparticles as magnetic resonance contrast agents for clinical imaging is established, they are more recently experiencing renewed interest as alternatives to gadolinium-based contrast agents. Ultra-small iron oxide nanoparticles have unique pharmacokinetics, metabolic and imaging properties. These properties have led to improved techniques for imaging a variety of vascular, oncologic and inflammatory conditions with iron oxide nanoparticles. Current research efforts are aimed at harnessing the characteristics of these nanoparticles to advance magnetic resonance imaging techniques and explore new therapeutic potentials. While there are some limitations to the use of iron oxide nanoparticles, including allergies to parenteral iron and iron storage disorders, the practicable applications for these agents will continue to expand. The purpose of this review is to provide a brief overview of the history and synthesis of iron oxide nanoparticles, their current applications in clinical imaging and their prospective clinical applications.

scholarly journals Toxicity of dimercaptosuccinate-coated and un-functionalized magnetic iron oxide nanoparticles towards aquatic organisms

2016 ◽  
Vol 3 (4) ◽  
pp. 754-767 ◽  
Author(s):  
Ya-Qi Zhang ◽  
Ralf Dringen ◽  
Charlotte Petters ◽  
Wiebke Rastedt ◽  
Jan Köser ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Colloidal Stability ◽  
Aquatic Organisms ◽  
Oxide Nanoparticles ◽  
Magnetic Iron Oxide Nanoparticles ◽  
Magnetic Iron Oxide ◽  
Ecotoxicological Effects

Investigations on colloidal stability and ecotoxicological effects of DMSA-coated and uncoated IONP with Raphidocelis, Daphnia and Lemna.

scholarly journals Iron Oxide Nanoparticles: An Alternative for Positive Contrast in Magnetic Resonance Imaging

Inorganics ◽  
2020 ◽  
Vol 8 (4) ◽  
pp. 28 ◽  
Author(s):  
Irene Fernández-Barahona ◽  
María Muñoz-Hernando ◽  
Jesus Ruiz-Cabello ◽  
Fernando Herranz ◽  
Juan Pellico
Keyword(s):  
Magnetic Resonance Imaging ◽  
Iron Oxide ◽  
Magnetic Resonance ◽  
Contrast Agents ◽  
Iron Oxide Nanoparticles ◽  
Positive Contrast ◽  
Oxide Nanoparticles ◽  
Resonance Imaging ◽  
The Past ◽  
T1 Contrast

Iron oxide nanoparticles have been extensively utilised as negative (T2) contrast agents in magnetic resonance imaging. In the past few years, researchers have also exploited their application as positive (T1) contrast agents to overcome the limitation of traditional Gd3+ contrast agents. To provide T1 contrast, these particles must present certain physicochemical properties with control over the size, morphology and surface of the particles. In this review, we summarise the reported T1 iron oxide nanoparticles and critically revise their properties, synthetic protocols and application, not only in MRI but also in multimodal imaging. In addition, we briefly summarise the most important nanoparticulate Gd and Mn agents to evaluate whether T1 iron oxide nanoparticles can reach Gd/Mn contrast capabilities.

COLLOIDAL STABILITY AND MONODISPERSIBLE MAGNETIC IRON OXIDE NANOPARTICLES IN BIOTECHNOLOGY APPLICATION

2013 ◽  
Vol 12 (06) ◽  
pp. 1330002 ◽  
Author(s):  
K. SHAMILI ◽  
E. M. RAJESH ◽  
R. RAJENDRAN ◽  
S. R. MADHAN SHANKAR ◽  
M. ELANGO ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Biomedical Applications ◽  
Colloidal Stability ◽  
Oxide Nanoparticles ◽  
Magnetic Iron Oxide Nanoparticles ◽  
Magnetic Fluid Hyperthermia ◽  
Magnetic Iron Oxide ◽  
Magnetic Resonance Imaging Mri ◽  
Co Precipitation

Magnetic iron oxide nanoparticles are promising material for various biological applications. In the recent decades, magnetic iron oxide nanoparticles (MNPs) have great attention in biomedical applications such as drug delivery, magnetic resonance imaging (MRI) and magnetic fluid hyperthermia (MFH). This review focuses on the colloidal stability and monodispersity properties of MNPs, which pay more attention toward biomedical applications. The simplest and the most promising method for the synthesis of MNPs is co-precipitation. The biocompatible MNPs are more interested in MRI application. This review also apportions synthesis, characterization and applications of MNP in biological and biomedical as theranostics and imaging.

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