scholarly journals X-ray radiation-induced and targeted photodynamic therapy with folic acid-conjugated biodegradable nanoconstructs

2018 ◽  
Vol Volume 13 ◽  
pp. 3553-3570 ◽  
Author(s):  
Sandhya Clement ◽  
Wenjie Chen ◽  
Wei Deng ◽  
Ewa M Goldys
Keyword(s):  
Photodynamic Therapy ◽  
Folic Acid ◽  
X Ray ◽  
Radiation Induced ◽  
Targeted Photodynamic Therapy

TiO2 hollow nanospheres functionalized with folic acid and ZnPc for targeted photodynamic therapy in glioblastoma cancer

2019 ◽  
Vol 9 (4) ◽  
pp. 1242-1248
Author(s):  
Minerva Uribe-Robles ◽  
Emma Ortiz-Islas ◽  
Ekaterina Rodriguez-Perez ◽  
Taehoon Lim ◽  
Alfredo A. Martinez-Morales
Keyword(s):  
Photodynamic Therapy ◽  
Folic Acid ◽  
Hollow Nanospheres ◽  
Image Position ◽  
Targeted Photodynamic Therapy

Abstract

Folic Acid–Conjugated Pyropheophorbide a as the Photosensitizer Tested for In Vivo Targeted Photodynamic Therapy

2017 ◽  
Vol 106 (6) ◽  
pp. 1482-1489 ◽  
Author(s):  
Jin Wang ◽  
Qian Liu ◽  
Yuting Zhang ◽  
Huan Shi ◽  
Hui Liu ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Folic Acid ◽  
Pyropheophorbide A ◽  
Targeted Photodynamic Therapy

scholarly journals Receptor-mediated Uptake of Folic Acid-functionalized Dextran Nanoparticles for Applications in Photodynamic Therapy

Polymers ◽  
2019 ◽  
Vol 11 (5) ◽  
pp. 896 ◽  
Author(s):  
Kathrin Butzbach ◽  
Matthias Konhäuser ◽  
Matthias Fach ◽  
Denise Bamberger ◽  
Benjamin Breitenbach ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Photodynamic Therapy ◽  
Folic Acid ◽  
Tumor Cells ◽  
Kb Cells ◽  
Promising Target ◽  
Nanoparticle System ◽  
Specific Uptake ◽  
Folic Acid Receptor ◽  
Targeted Photodynamic Therapy

In photodynamic therapy (PDT), photosensitizers and light are used to cause photochemically induced cell death. The selectivity and the effectiveness of the phototoxicity in cancer can be increased by a specific uptake of the photosensitizer into tumor cells. A promising target for this goal is the folic acid receptor α (FRα), which is overexpressed on the surface of many tumor cells and mediates an endocytotic uptake. Here, we describe a polysaccharide-based nanoparticle system suitable for targeted uptake and its photochemical and photobiological characterization. The photosensitizer 5, 10, 15, 20-tetraphenyl-21H, 23H-porphyrine (TPP) was encapsulated in spermine- and acetal-modified dextran (SpAcDex) nanoparticles and conjugated with folic acid (FA) on the surface [SpAcDex(TPP)-FA]. The particles are successfully taken up by human HeLa-KB cells, and a light-induced cytotoxicity is observable. An excess of free folate as the competitor for the FRα-mediated uptake inhibits the phototoxicity. In conclusion, folate-modified SpAcDex particles are a promising drug delivery system for a tumor cell targeted photodynamic therapy.

The Interest of Folic Acid in Targeted Photodynamic Therapy

2015 ◽  
Vol 22 (27) ◽  
pp. 3185-3207 ◽  
Author(s):  
Aurelie Stallivieri ◽  
Francis Baros ◽  
Gulim Jetpisbayeva ◽  
Bauyrzhan Myrzakhmetov ◽  
Celine Frochot
Keyword(s):  
Photodynamic Therapy ◽  
Folic Acid ◽  
Targeted Photodynamic Therapy

scholarly journals Folic Acid Fortification Prevents Morphological and Behavioral Consequences of X-Ray Exposure During Neurulation

2021 ◽  
Vol 14 ◽  
Author(s):  
Kai Craenen ◽  
Mieke Verslegers ◽  
Zsuzsanna Callaerts-Vegh ◽  
Livine Craeghs ◽  
Jasmine Buset ◽  
...  
Keyword(s):  
Folic Acid ◽  
Birth Defects ◽  
Time Window ◽  
Cervical Vertebrae ◽  
High Dose ◽  
Food Fortification ◽  
Fiber Layer ◽  
X Ray ◽  
Radiation Induced ◽  
The Impact

Previous studies suggested a causal link between pre-natal exposure to ionizing radiation and birth defects such as microphthalmos and exencephaly. In mice, these defects arise primarily after high-dose X-irradiation during early neurulation. However, the impact of sublethal (low) X-ray doses during this early developmental time window on adult behavior and morphology of central nervous system structures is not known. In addition, the efficacy of folic acid (FA) in preventing radiation-induced birth defects and persistent radiation-induced anomalies has remained unexplored. To assess the efficacy of FA in preventing radiation-induced defects, pregnant C57BL6/J mice were X-irradiated at embryonic day (E)7.5 and were fed FA-fortified food. FA partially prevented radiation-induced (1.0 Gy) anophthalmos, exencephaly and gastroschisis at E18, and reduced the number of pre-natal deaths, fetal weight loss and defects in the cervical vertebrae resulting from irradiation. Furthermore, FA food fortification counteracted radiation-induced impairments in vision and olfaction, which were evidenced after exposure to doses ≥0.1 Gy. These findings coincided with the observation of a reduction in thickness of the retinal ganglion cell and nerve fiber layer, and a decreased axial length of the eye following exposure to 0.5 Gy. Finally, MRI studies revealed a volumetric decrease of the hippocampus, striatum, thalamus, midbrain and pons following 0.5 Gy irradiation, which could be partially ameliorated after FA food fortification. Altogether, our study is the first to offer detailed insights into the long-term consequences of X-ray exposure during neurulation, and supports the use of FA as a radioprotectant and antiteratogen to counter the detrimental effects of X-ray exposure during this crucial period of gestation.

OFF/ON galvanic replacement reaction for preparing divergent AuAg nano-hollows as a SERS-visualized drug delivery system in targeted photodynamic therapy

RSC Advances ◽  
2016 ◽  
Vol 6 (69) ◽  
pp. 64494-64498 ◽  
Author(s):  
Chih-Chia Huang ◽  
Pei-Hua Lin ◽  
Chien-Wei Lee
Keyword(s):  
Drug Delivery ◽  
Photodynamic Therapy ◽  
Folic Acid ◽  
Proton Exchange ◽  
Detection Sensitivity ◽  
Galvanic Replacement ◽  
Galvanic Replacement Reaction ◽  
Replacement Reaction ◽  
Photodynamic Therapy Of Cancer ◽  
Targeted Photodynamic Therapy

3-D AuAg nano-hollows were fabricated by an anti-galvanic replacement reaction (off), followed by a proton exchange reaction (on). They exhibited superior Raman detection sensitivity for potentially imaging-guided and folic acid-targeted photodynamic therapy of cancer cells.

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