TiO2 hollow nanospheres functionalized with folic acid and ZnPc for targeted photodynamic therapy in glioblastoma cancer

2019 ◽  
Vol 9 (4) ◽  
pp. 1242-1248
Author(s):  
Minerva Uribe-Robles ◽  
Emma Ortiz-Islas ◽  
Ekaterina Rodriguez-Perez ◽  
Taehoon Lim ◽  
Alfredo A. Martinez-Morales
Keyword(s):  
Photodynamic Therapy ◽  
Folic Acid ◽  
Hollow Nanospheres ◽  
Image Position ◽  
Targeted Photodynamic Therapy

Abstract

Folic Acid–Conjugated Pyropheophorbide a as the Photosensitizer Tested for In Vivo Targeted Photodynamic Therapy

2017 ◽  
Vol 106 (6) ◽  
pp. 1482-1489 ◽  
Author(s):  
Jin Wang ◽  
Qian Liu ◽  
Yuting Zhang ◽  
Huan Shi ◽  
Hui Liu ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Folic Acid ◽  
Pyropheophorbide A ◽  
Targeted Photodynamic Therapy

scholarly journals Receptor-mediated Uptake of Folic Acid-functionalized Dextran Nanoparticles for Applications in Photodynamic Therapy

Polymers ◽  
2019 ◽  
Vol 11 (5) ◽  
pp. 896 ◽  
Author(s):  
Kathrin Butzbach ◽  
Matthias Konhäuser ◽  
Matthias Fach ◽  
Denise Bamberger ◽  
Benjamin Breitenbach ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Photodynamic Therapy ◽  
Folic Acid ◽  
Tumor Cells ◽  
Kb Cells ◽  
Promising Target ◽  
Nanoparticle System ◽  
Specific Uptake ◽  
Folic Acid Receptor ◽  
Targeted Photodynamic Therapy

In photodynamic therapy (PDT), photosensitizers and light are used to cause photochemically induced cell death. The selectivity and the effectiveness of the phototoxicity in cancer can be increased by a specific uptake of the photosensitizer into tumor cells. A promising target for this goal is the folic acid receptor α (FRα), which is overexpressed on the surface of many tumor cells and mediates an endocytotic uptake. Here, we describe a polysaccharide-based nanoparticle system suitable for targeted uptake and its photochemical and photobiological characterization. The photosensitizer 5, 10, 15, 20-tetraphenyl-21H, 23H-porphyrine (TPP) was encapsulated in spermine- and acetal-modified dextran (SpAcDex) nanoparticles and conjugated with folic acid (FA) on the surface [SpAcDex(TPP)-FA]. The particles are successfully taken up by human HeLa-KB cells, and a light-induced cytotoxicity is observable. An excess of free folate as the competitor for the FRα-mediated uptake inhibits the phototoxicity. In conclusion, folate-modified SpAcDex particles are a promising drug delivery system for a tumor cell targeted photodynamic therapy.

The Interest of Folic Acid in Targeted Photodynamic Therapy

2015 ◽  
Vol 22 (27) ◽  
pp. 3185-3207 ◽  
Author(s):  
Aurelie Stallivieri ◽  
Francis Baros ◽  
Gulim Jetpisbayeva ◽  
Bauyrzhan Myrzakhmetov ◽  
Celine Frochot
Keyword(s):  
Photodynamic Therapy ◽  
Folic Acid ◽  
Targeted Photodynamic Therapy

OFF/ON galvanic replacement reaction for preparing divergent AuAg nano-hollows as a SERS-visualized drug delivery system in targeted photodynamic therapy

RSC Advances ◽  
2016 ◽  
Vol 6 (69) ◽  
pp. 64494-64498 ◽  
Author(s):  
Chih-Chia Huang ◽  
Pei-Hua Lin ◽  
Chien-Wei Lee
Keyword(s):  
Drug Delivery ◽  
Photodynamic Therapy ◽  
Folic Acid ◽  
Proton Exchange ◽  
Detection Sensitivity ◽  
Galvanic Replacement ◽  
Galvanic Replacement Reaction ◽  
Replacement Reaction ◽  
Photodynamic Therapy Of Cancer ◽  
Targeted Photodynamic Therapy

3-D AuAg nano-hollows were fabricated by an anti-galvanic replacement reaction (off), followed by a proton exchange reaction (on). They exhibited superior Raman detection sensitivity for potentially imaging-guided and folic acid-targeted photodynamic therapy of cancer cells.

Folic acid-modified phthalocyanine-nanozyme loaded liposomes for targeted photodynamic therapy

2021 ◽  
Vol 36 ◽  
pp. 102527
Author(s):  
Nnamdi Nwahara ◽  
Garth Abrahams ◽  
Earl Prinsloo ◽  
Tebello Nyokong
Keyword(s):  
Photodynamic Therapy ◽  
Folic Acid ◽  
Targeted Photodynamic Therapy
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