OFF/ON galvanic replacement reaction for preparing divergent AuAg nano-hollows as a SERS-visualized drug delivery system in targeted photodynamic therapy

RSC Advances ◽  
2016 ◽  
Vol 6 (69) ◽  
pp. 64494-64498 ◽  
Author(s):  
Chih-Chia Huang ◽  
Pei-Hua Lin ◽  
Chien-Wei Lee
Keyword(s):  
Drug Delivery ◽  
Photodynamic Therapy ◽  
Folic Acid ◽  
Proton Exchange ◽  
Detection Sensitivity ◽  
Galvanic Replacement ◽  
Galvanic Replacement Reaction ◽  
Replacement Reaction ◽  
Photodynamic Therapy Of Cancer ◽  
Targeted Photodynamic Therapy

3-D AuAg nano-hollows were fabricated by an anti-galvanic replacement reaction (off), followed by a proton exchange reaction (on). They exhibited superior Raman detection sensitivity for potentially imaging-guided and folic acid-targeted photodynamic therapy of cancer cells.

scholarly journals Receptor-mediated Uptake of Folic Acid-functionalized Dextran Nanoparticles for Applications in Photodynamic Therapy

Polymers ◽  
2019 ◽  
Vol 11 (5) ◽  
pp. 896 ◽  
Author(s):  
Kathrin Butzbach ◽  
Matthias Konhäuser ◽  
Matthias Fach ◽  
Denise Bamberger ◽  
Benjamin Breitenbach ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Photodynamic Therapy ◽  
Folic Acid ◽  
Tumor Cells ◽  
Kb Cells ◽  
Promising Target ◽  
Nanoparticle System ◽  
Specific Uptake ◽  
Folic Acid Receptor ◽  
Targeted Photodynamic Therapy

In photodynamic therapy (PDT), photosensitizers and light are used to cause photochemically induced cell death. The selectivity and the effectiveness of the phototoxicity in cancer can be increased by a specific uptake of the photosensitizer into tumor cells. A promising target for this goal is the folic acid receptor α (FRα), which is overexpressed on the surface of many tumor cells and mediates an endocytotic uptake. Here, we describe a polysaccharide-based nanoparticle system suitable for targeted uptake and its photochemical and photobiological characterization. The photosensitizer 5, 10, 15, 20-tetraphenyl-21H, 23H-porphyrine (TPP) was encapsulated in spermine- and acetal-modified dextran (SpAcDex) nanoparticles and conjugated with folic acid (FA) on the surface [SpAcDex(TPP)-FA]. The particles are successfully taken up by human HeLa-KB cells, and a light-induced cytotoxicity is observable. An excess of free folate as the competitor for the FRα-mediated uptake inhibits the phototoxicity. In conclusion, folate-modified SpAcDex particles are a promising drug delivery system for a tumor cell targeted photodynamic therapy.

Bimetallic Cu–Pd alloy multipods and their highly electrocatalytic performance for formic acid oxidation and oxygen reduction

2017 ◽  
Vol 5 (9) ◽  
pp. 4421-4429 ◽  
Author(s):  
Dong Chen ◽  
Pengcheng Sun ◽  
Hui Liu ◽  
Jun Yang
Keyword(s):  
Formic Acid ◽  
Oxygen Reduction ◽  
Formic Acid Oxidation ◽  
Acid Oxidation ◽  
Galvanic Replacement ◽  
Galvanic Replacement Reaction ◽  
Replacement Reaction ◽  
Electrocatalytic Performance ◽  
Pd Alloy

Nanoscale Cu–Pd alloy multipods were synthesized via the galvanic replacement reaction for catalyzing formic acid oxidation and oxygen reduction.

Bismuth-induced synthesis of Au–X (X = Pt, Pd) nanoalloys for electrocatalytic reactions

2021 ◽  
Author(s):  
Nan Wang ◽  
Wei Zhao ◽  
Miaolei Zhang ◽  
Pengfei Cao ◽  
Shengjun Sun ◽  
...  
Keyword(s):  
Galvanic Replacement ◽  
Galvanic Replacement Reaction ◽  
Replacement Reaction ◽  
Reaction Method ◽  
Electrocatalytic Reaction ◽  
Electrocatalytic Reactions

The synthesis of Au–X (X = Pt, Pd) nanoalloys based on Bi as an intermediate using the galvanic replacement reaction method for electrocatalytic reaction.

Palladium Deposition on Nickel Wire Electrodes by a Galvanic Replacement Reaction

2019 ◽  
Vol 2 (3) ◽  
pp. 2337-2343 ◽  
Author(s):  
Yusuke Kobayashi ◽  
Hiromu Yoshida ◽  
Sunyhik Ahn ◽  
Gang Chang ◽  
Munetaka Oyama
Keyword(s):  
Galvanic Replacement ◽  
Nickel Wire ◽  
Galvanic Replacement Reaction ◽  
Replacement Reaction
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