scholarly journals pH-triggered surface charge-switchable polymer micelles for the co-delivery of paclitaxel/disulfiram and overcoming multidrug resistance in cancer

2017 ◽  
Vol Volume 12 ◽  
pp. 8631-8647 ◽  
Author(s):  
Qiang Huo ◽  
Jianhua Zhu ◽  
Yimin Niu ◽  
Huihui Shi ◽  
Yaxiang Gong ◽  
...  
Keyword(s):  
Multidrug Resistance ◽  
Surface Charge ◽  
Polymer Micelles

Hybrid polymer micelles capable of cRGD targeting and pH-triggered surface charge conversion for tumor selective accumulation and promoted uptake

2014 ◽  
Vol 50 (65) ◽  
pp. 9188-9191 ◽  
Author(s):  
Xiuli Hu ◽  
Xingang Guan ◽  
Jing Li ◽  
Qing Pei ◽  
Ming Liu ◽  
...  
Keyword(s):  
Tumor Microenvironment ◽  
Surface Charge ◽  
Active Targeting ◽  
Hybrid Polymer ◽  
Polymer Micelles ◽  
Dual Functional ◽  
Stimuli Response ◽  
Selective Accumulation ◽  
Tumor Selective

Dual functional micelles combining active targeting (cRGD) and tumor microenvironment stimuli response used for Dox delivery.

Triggered ferroptotic polymer micelles for reversing multidrug resistance to chemotherapy

Biomaterials ◽  
2019 ◽  
Vol 223 ◽  
pp. 119486 ◽  
Author(s):  
Min Gao ◽  
Jian Deng ◽  
Fang Liu ◽  
Aiping Fan ◽  
Yujuan Wang ◽  
...  
Keyword(s):  
Multidrug Resistance ◽  
Polymer Micelles ◽  
Resistance To Chemotherapy

scholarly journals Micelle-Forming Block Copolymers Tailored for Inhibition of P-gp-Mediated Multidrug Resistance: Structure to Activity Relationship

Pharmaceutics ◽  
2019 ◽  
Vol 11 (11) ◽  
pp. 579 ◽  
Author(s):  
Braunová ◽  
Kaňa ◽  
Kudláčová ◽  
Kostka ◽  
Bouček ◽  
...  
Keyword(s):  
Multidrug Resistance ◽  
Block Copolymers ◽  
Drug Carriers ◽  
Biological Properties ◽  
Polypropylene Glycol ◽  
Polymer Micelles ◽  
Glycoprotein P ◽  
Block Polymer

Multidrug resistance (MDR) is often caused by the overexpression of efflux pumps, such as ABC transporters, in particular, P-glycoprotein (P-gp). Here, we investigate the di- and tri- block amphiphilic polymer systems based on polypropylene glycol (PPO) and copolymers of (N-(2-hydroxypropyl)methacrylamide) (PHPMA) as potential macromolecular inhibitors of P-gp, and concurrently, carriers of drugs, passively targeting solid tumors by the enhanced permeability and retention (EPR) effect. Interestingly, there were significant differences between the effects of di- and tri- block polymer-based micelles, with the former being significantly more thermodynamically stable and showing much higher P-gp inhibition ability. The presence of Boc-protected hydrazide groups or the Boc-deprotection method did not affect the physico-chemical or biological properties of the block copolymers. Moreover, diblock polymer micelles could be loaded with free PPO containing 5–40 wt % of free PPO, which showed increased P-gp inhibition in comparison to the unloaded micelles. Loaded polymer micelles containing more than 20 wt % free PPO showed a significant increase in toxicity; thus, loaded diblock polymer micelles containing 5–15 wt % free PPO are potential candidates for in vitro and in vivo application as potent MDR inhibitors and drug carriers.

Bacterial biofilm destruction by size/surface charge-adaptive micelles

Nanoscale ◽  
2019 ◽  
Vol 11 (3) ◽  
pp. 1410-1422 ◽  
Author(s):  
Maohua Chen ◽  
Jiaojun Wei ◽  
Songzhi Xie ◽  
Xinyan Tao ◽  
Zhanlin Zhang ◽  
...  
Keyword(s):  
Multidrug Resistance ◽  
Surface Charge ◽  
Pathogenic Bacteria ◽  
Bacterial Biofilm ◽  
Biofilm Destruction

Biofilms formed by pathogenic bacteria are one of the most important reasons for multidrug resistance.

Imaging molecules adsorbed onto electrodes under potential control by scanning probe microscopy

1991 ◽  
Vol 49 ◽  
pp. 376-377 ◽  
Author(s):  
N.J. Tao ◽  
J.A. DeRose ◽  
P.I. Oden ◽  
S.M. Lindsay
Keyword(s):  
Surface Charge ◽  
Environmental Effects ◽  
Scanning Probe Microscopy ◽  
Statistical Significance ◽  
Electrochemical Methods ◽  
Surface Structures ◽  
Scanning Probe ◽  
Potential Control ◽  
Afm Imaging ◽  
Special Circumstances

Clemmer and Beebe have pointed out that surface structures on graphite substrates can be misinterpreted as biopolymer images in STM experiments. We have been using electrochemical methods to react DNA fragments onto gold electrodes for STM and AFM imaging. The adsorbates produced in this way are only homogeneous in special circumstances. Searching an inhomogeneous substrate for ‘desired’ images limits the value of the data. Here, we report on a reversible method for imaging adsorbates. The molecules can be lifted onto and off the substrate during imaging. This leaves no doubt about the validity or statistical significance of the images. Furthermore, environmental effects (such as changes in electrolyte or surface charge) can be investigated easily.

Study of the mechanism responsible for multidrug resistance in breast cancer MCF-7 cell mediated by 14-3-3σ

2010 ◽  
Vol 34 (8) ◽  
pp. S47-S47
Author(s):  
Guopei Zheng ◽  
Sisi Yi ◽  
Yafei Li ◽  
Fangren Kong ◽  
Yanhui Yu ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Multidrug Resistance ◽  
Mcf 7

Expression and localization of the multidrug resistance proteins MRP2 and MRP3 in human gallbladder epithelia

2001 ◽  
Vol 120 (5) ◽  
pp. A93-A93
Author(s):  
D ROST ◽  
J KONIG ◽  
G WEISS ◽  
E KLAR ◽  
W STREMMEL ◽  
...  
Keyword(s):  
Multidrug Resistance ◽  
Multidrug Resistance Proteins ◽  
Human Gallbladder ◽  
Resistance Proteins
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