Hybrid polymer micelles capable of cRGD targeting and pH-triggered surface charge conversion for tumor selective accumulation and promoted uptake

2014 ◽  
Vol 50 (65) ◽  
pp. 9188-9191 ◽  
Author(s):  
Xiuli Hu ◽  
Xingang Guan ◽  
Jing Li ◽  
Qing Pei ◽  
Ming Liu ◽  
...  
Keyword(s):  
Tumor Microenvironment ◽  
Surface Charge ◽  
Active Targeting ◽  
Hybrid Polymer ◽  
Polymer Micelles ◽  
Dual Functional ◽  
Stimuli Response ◽  
Selective Accumulation ◽  
Tumor Selective

Dual functional micelles combining active targeting (cRGD) and tumor microenvironment stimuli response used for Dox delivery.

scholarly journals Highly efficient and tumor-selective nanoparticles for dual-targeted immunogene therapy against cancer

2020 ◽  
Vol 6 (3) ◽  
pp. eaax5032 ◽  
Author(s):  
Kuan-Wei Huang ◽  
Fu-Fei Hsu ◽  
Jiantai Timothy Qiu ◽  
Guann-Jen Chern ◽  
Yi-An Lee ◽  
...  
Keyword(s):  
Tumor Microenvironment ◽  
Cancer Immunotherapy ◽  
Plasmid Dna ◽  
Systemic Toxicity ◽  
Great Promise ◽  
Anticancer Efficacy ◽  
Highly Efficient ◽  
Immunogene Therapy ◽  
Immunosuppressive Tumor Microenvironment ◽  
Tumor Selective

While immunotherapy holds great promise for combating cancer, the limited efficacy due to an immunosuppressive tumor microenvironment and systemic toxicity hinder the broader application of cancer immunotherapy. Here, we report a combinatorial immunotherapy approach that uses a highly efficient and tumor-selective gene carrier to improve anticancer efficacy and circumvent the systemic toxicity. In this study, we engineered tumor-targeted lipid-dendrimer-calcium-phosphate (TT-LDCP) nanoparticles (NPs) with thymine-functionalized dendrimers that exhibit not only enhanced gene delivery capacity but also immune adjuvant properties by activating the stimulator of interferon genes (STING)–cGAS pathway. TT-LDCP NPs delivered siRNA against immune checkpoint ligand PD-L1 and immunostimulatory IL-2–encoding plasmid DNA to hepatocellular carcinoma (HCC), increased tumoral infiltration and activation of CD8+ T cells, augmented the efficacy of cancer vaccine immunotherapy, and suppressed HCC progression. Our work presents nanotechnology-enabled dual delivery of siRNA and plasmid DNA that selectively targets and reprograms the immunosuppressive tumor microenvironment to improve cancer immunotherapy.

scholarly journals Biological reduction of nitroimidazole-functionalized gold nanorods for photoacoustic imaging of tumor hypoxia

RSC Advances ◽  
2019 ◽  
Vol 9 (29) ◽  
pp. 16863-16868 ◽  
Author(s):  
Yui Umehara ◽  
Toki Kageyama ◽  
Aoi Son ◽  
Yu Kimura ◽  
Teruyuki Kondo ◽  
...  
Keyword(s):  
Gold Nanorods ◽  
Photoacoustic Imaging ◽  
Tumor Hypoxia ◽  
Biological Reduction ◽  
Selective Accumulation ◽  
Tumor Selective

Tumor-selective accumulation of gold nanorods (GNR) has been demonstrated for visualization of tumor hypoxia by photoacoustic imaging.

scholarly journals Biodegradable hybrid polymer micelles for combination drug therapy in ovarian cancer

2013 ◽  
Vol 171 (3) ◽  
pp. 339-348 ◽  
Author(s):  
Swapnil S. Desale ◽  
Samuel M. Cohen ◽  
Yi Zhao ◽  
Alexander V. Kabanov ◽  
Tatiana K. Bronich
Keyword(s):  
Ovarian Cancer ◽  
Drug Therapy ◽  
Combination Drug Therapy ◽  
Hybrid Polymer ◽  
Polymer Micelles ◽  
Combination Drug

scholarly journals pH-triggered surface charge-switchable polymer micelles for the co-delivery of paclitaxel/disulfiram and overcoming multidrug resistance in cancer

2017 ◽  
Vol Volume 12 ◽  
pp. 8631-8647 ◽  
Author(s):  
Qiang Huo ◽  
Jianhua Zhu ◽  
Yimin Niu ◽  
Huihui Shi ◽  
Yaxiang Gong ◽  
...  
Keyword(s):  
Multidrug Resistance ◽  
Surface Charge ◽  
Polymer Micelles

scholarly journals A Robust Approach to Enhance Tumor-selective Accumulation of Nanoparticles

Oncotarget ◽  
2011 ◽  
Vol 2 (1-2) ◽  
pp. 59-68 ◽  
Author(s):  
Yuan Qiao ◽  
Xin Huang ◽  
Sridhar Nimmagadda ◽  
Renyuan Bai ◽  
Verena Staedtke ◽  
...  
Keyword(s):  
Robust Approach ◽  
Selective Accumulation ◽  
Tumor Selective

Intratumoral delivery of M-CSF by calcium crosslinked polymer micelles enhances cancer immunotherapy

2019 ◽  
Vol 7 (7) ◽  
pp. 2769-2776 ◽  
Author(s):  
Kuirong Mao ◽  
Xiuxiu Cong ◽  
Liangzhu Feng ◽  
Hongmei Chen ◽  
Jialiang Wang ◽  
...  
Keyword(s):  
Tumor Microenvironment ◽  
Cancer Immunotherapy ◽  
Polymer Micelles ◽  
Antitumor Effects ◽  
Crosslinked Polymer ◽  
Intratumoral Delivery ◽  
Cascade Amplification

This study provides new avenues for cascade amplification of the antitumor effects by regulating the tumor microenvironment.

Abstract 1851: Responses of a novel tumor selective anti-CD137 agonist antibody activated by elevated extracellular ATP in tumor microenvironment

2021 ◽  
Author(s):  
Mika Kamata-Sakurai ◽  
Yoshinori Narita ◽  
Ryo Uchikawa ◽  
Kenji Taniguchi ◽  
Sayuri Horikawa ◽  
...  
Keyword(s):  
Tumor Microenvironment ◽  
Extracellular Atp ◽  
Agonist Antibody ◽  
Tumor Selective

Hybrid polymer/ionic liquid electrospun membranes with tunable surface charge for virus capture in aqueous environments

2021 ◽  
Vol 43 ◽  
pp. 102278
Author(s):  
Andrea Merenda ◽  
Ana Claudia Canalli Bortolassi ◽  
Julio Rodriguez-Andres ◽  
Riyadh Al-Attabi ◽  
Jürg A. Schütz ◽  
...  
Keyword(s):  
Ionic Liquid ◽  
Surface Charge ◽  
Hybrid Polymer ◽  
Aqueous Environments ◽  
Electrospun Membranes
Sign in / Sign up

Export Citation Format

Share Document