scholarly journals Annihilation of Leishmania by daylight responsive ZnO nanoparticles: a temporal relationship of reactive oxygen species-induced lipid and protein oxidation

2016 ◽  
pp. 2451 ◽  
Author(s):  
Akhtar Nadhman ◽  
Malik Ihsanullah Khan ◽  
Samina Nazir ◽  
Momin Khan ◽  
Gul Shahnaz ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Zno Nanoparticles ◽  
Protein Oxidation ◽  
Temporal Relationship ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Lipid And Protein Oxidation ◽  
Relationship Of

Sono-synthesis approach improves anticancer activity of ZnO nanoparticles: reactive oxygen species depletion for killing human osteosarcoma cells

Nanomedicine ◽  
2021 ◽  
Vol 16 (8) ◽  
pp. 657-671
Author(s):  
Mansoureh Parsa ◽  
Mohammad H Entezari ◽  
Azadeh Meshkini
Keyword(s):  
Reactive Oxygen Species ◽  
Anticancer Activity ◽  
Zno Nanoparticles ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Zno Nps ◽  
Human Osteosarcoma ◽  
Human Osteosarcoma Cells ◽  
Tumor Selectivity ◽  
Biological Tests

Aim: To investigate the effect of ultrasound during the synthesis of ZnO nanoparticles (NPs) on their anticancer activity. Materials & methods: ZnO NPs were synthesized in the presence and absence of ultrasonic irradiation. Biological tests were performed on human osteosarcoma cancer cells (Saos-2). Results: The sono-synthesized sample indicated higher cytotoxicity than the conventional one. (IC50 = 16.48 ± 0.41 μg/ml for sonochemical ZnO; 26.96 ± 0.33 μg/ml for conventional ZnO). Both sonochemical and conventional samples acted like antioxidants and reduced intracellular reactive oxygen species level. This reduction was more significant in cells treated with the sono-synthesized sample. The sono-synthesized ZnO NPs showed more tumor selectivity than the conventional sample. Conclusion: Sono-synthesis of ZnO NPs by a bath sonicator could improve their anticancer activity.

scholarly journals ZnO nanoparticles induced reactive oxygen species promotes multimodal cyto- and epigenetic toxicity

2017 ◽  
pp. kfw252 ◽  
Author(s):  
Samrat Roy Choudhury ◽  
Josue Ordaz ◽  
Chiao-Ling Lo ◽  
Nur P. Damayanti ◽  
Feng Zhou ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Zno Nanoparticles ◽  
Reactive Oxygen ◽  
Oxygen Species

Role of the dissolved zinc ion and reactive oxygen species in cytotoxicity of ZnO nanoparticles

2010 ◽  
Vol 199 (3) ◽  
pp. 389-397 ◽  
Author(s):  
Wenhua Song ◽  
Jinyang Zhang ◽  
Jing Guo ◽  
Jinhua Zhang ◽  
Feng Ding ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Zno Nanoparticles ◽  
Reactive Oxygen ◽  
Zinc Ion ◽  
Oxygen Species

scholarly journals SARS-CoV-2 and Other Respiratory Viruses: What Does Oxidative Stress Have to Do with It?

2020 ◽  
Vol 2020 ◽  
pp. 1-13
Author(s):  
Iara Grigoletto Fernandes ◽  
Cyro Alves de Brito ◽  
Vitor Manoel Silva dos Reis ◽  
Maria Notomi Sato ◽  
Nátalli Zanete Pereira
Keyword(s):  
Oxidative Stress ◽  
Reactive Oxygen Species ◽  
Severe Acute Respiratory Syndrome ◽  
Viral Infections ◽  
Reactive Oxygen ◽  
Antioxidant Compounds ◽  
Oxygen Species ◽  
Antiviral Therapies ◽  
Species Production ◽  
Relationship Of

The phenomenon of oxidative stress, characterized as an imbalance in the production of reactive oxygen species and antioxidant responses, is a well-known inflammatory mechanism and constitutes an important cellular process. The relationship of viral infections, reactive species production, oxidative stress, and the antiviral response is relevant. Therefore, the aim of this review is to report studies showing how reactive oxygen species may positively or negatively affect the pathophysiology of viral infection. We focus on known respiratory viral infections, especially severe acute respiratory syndrome coronaviruses (SARS-CoVs), in an attempt to provide important information on the challenges posed by the current COVID-19 pandemic. Because antiviral therapies for severe acute respiratory syndrome coronaviruses (e.g., SARS-CoV-2) are rare, knowledge about relevant antioxidant compounds and oxidative pathways may be important for understanding viral pathogenesis and identifying possible therapeutic targets.

Effects of Surface Chemistry on Cytotoxicity, Genotoxicity, and the Generation of Reactive Oxygen Species Induced by ZnO Nanoparticles

Langmuir ◽  
2010 ◽  
Vol 26 (19) ◽  
pp. 15399-15408 ◽  
Author(s):  
Hong Yin ◽  
Philip S. Casey ◽  
Maxine J. McCall ◽  
Michael Fenech
Keyword(s):  
Reactive Oxygen Species ◽  
Surface Chemistry ◽  
Zno Nanoparticles ◽  
Reactive Oxygen ◽  
Oxygen Species

Low Concentrations of Zinc Oxide Nanoparticles Cause Severe Cytotoxicity Through Increased Intracellular Reactive Oxygen Species

2021 ◽  
Vol 17 (12) ◽  
pp. 2420-2432
Author(s):  
Shichen Xie ◽  
Jingyao Zhu ◽  
Dicheng Yang ◽  
Yan Xu ◽  
Jun Zhu ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Zinc Oxide ◽  
Zno Nanoparticles ◽  
Reactive Oxygen ◽  
Alveolar Epithelial Cells ◽  
Oxygen Species ◽  
Dipalmitoyl Phosphatidylcholine ◽  
Alveolar Epithelial ◽  
Low Concentrations

With wide application of Zinc oxide (ZnO) nanoparticles, their biological toxicity has received more and more attention in recent years. In this research, two ZnO dispersions with different particle sizes, small size Zinc oxide (S-ZnO) and big size Zinc oxide (B-ZnO), were prepared using polycarboxylic acid as dispersant. We found that the S-ZnO nanoparticles showed stronger toxicity on Human Pulmonary Alveolar Epithelial Cells (HPAEpiC) under same concentration. Only 9 ppm S-ZnO could decrease HPAEpiC viability to about 50%, which means that, a small amount of well-dispersed ZnO nanoparticles in industrial production process may cause serious damage to the human body through oral inhalation. Focusing on mechanism for cytotoxicity, ZnO nanoparticles promoted generation and accumulation of Reactive Oxygen Species (ROS) in mitochondria via inhibiting Superoxide Dismutase (SOD) enzyme activity and reducing Glutathione (GSH) content. ROS in turn opened the mitochondrial Ca2+ pathway and lowered the Mitochondrial Membrane Potentials (MMP), leading to cell death. To simulate the lung environment in vitro, mixed dipalmitoyl phosphatidylcholine (DPPC) and ZnO nanoparticles (1:1) were incubated for 72 hours and then cytotoxicity was evaluated on HPAEpiC. Results showed that the cell viability was significantly increased, which proved that the DPPC effectively inhibited the toxicity of ZnO nanoparticles.

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