Effects of Surface Chemistry on Cytotoxicity, Genotoxicity, and the Generation of Reactive Oxygen Species Induced by ZnO Nanoparticles

Langmuir ◽  
2010 ◽  
Vol 26 (19) ◽  
pp. 15399-15408 ◽  
Author(s):  
Hong Yin ◽  
Philip S. Casey ◽  
Maxine J. McCall ◽  
Michael Fenech
Keyword(s):  
Reactive Oxygen Species ◽  
Surface Chemistry ◽  
Zno Nanoparticles ◽  
Reactive Oxygen ◽  
Oxygen Species

Sono-synthesis approach improves anticancer activity of ZnO nanoparticles: reactive oxygen species depletion for killing human osteosarcoma cells

Nanomedicine ◽  
2021 ◽  
Vol 16 (8) ◽  
pp. 657-671
Author(s):  
Mansoureh Parsa ◽  
Mohammad H Entezari ◽  
Azadeh Meshkini
Keyword(s):  
Reactive Oxygen Species ◽  
Anticancer Activity ◽  
Zno Nanoparticles ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Zno Nps ◽  
Human Osteosarcoma ◽  
Human Osteosarcoma Cells ◽  
Tumor Selectivity ◽  
Biological Tests

Aim: To investigate the effect of ultrasound during the synthesis of ZnO nanoparticles (NPs) on their anticancer activity. Materials & methods: ZnO NPs were synthesized in the presence and absence of ultrasonic irradiation. Biological tests were performed on human osteosarcoma cancer cells (Saos-2). Results: The sono-synthesized sample indicated higher cytotoxicity than the conventional one. (IC50 = 16.48 ± 0.41 μg/ml for sonochemical ZnO; 26.96 ± 0.33 μg/ml for conventional ZnO). Both sonochemical and conventional samples acted like antioxidants and reduced intracellular reactive oxygen species level. This reduction was more significant in cells treated with the sono-synthesized sample. The sono-synthesized ZnO NPs showed more tumor selectivity than the conventional sample. Conclusion: Sono-synthesis of ZnO NPs by a bath sonicator could improve their anticancer activity.

scholarly journals Beyond Strain: Controlling the Surface Chemistry of CsPbI3 Nanocrystal Films for Improved Stability against Ambient Reactive Oxygen Species

2020 ◽  
Vol 32 (18) ◽  
pp. 7850-7860
Author(s):  
Taylor Moot ◽  
Desislava R. Dikova ◽  
Abhijit Hazarika ◽  
Tracy H. Schloemer ◽  
Severin N. Habisreutinger ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Surface Chemistry ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Improved Stability ◽  
Nanocrystal Films

scholarly journals ZnO nanoparticles induced reactive oxygen species promotes multimodal cyto- and epigenetic toxicity

2017 ◽  
pp. kfw252 ◽  
Author(s):  
Samrat Roy Choudhury ◽  
Josue Ordaz ◽  
Chiao-Ling Lo ◽  
Nur P. Damayanti ◽  
Feng Zhou ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Zno Nanoparticles ◽  
Reactive Oxygen ◽  
Oxygen Species

Role of the dissolved zinc ion and reactive oxygen species in cytotoxicity of ZnO nanoparticles

2010 ◽  
Vol 199 (3) ◽  
pp. 389-397 ◽  
Author(s):  
Wenhua Song ◽  
Jinyang Zhang ◽  
Jing Guo ◽  
Jinhua Zhang ◽  
Feng Ding ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Zno Nanoparticles ◽  
Reactive Oxygen ◽  
Zinc Ion ◽  
Oxygen Species

Low Concentrations of Zinc Oxide Nanoparticles Cause Severe Cytotoxicity Through Increased Intracellular Reactive Oxygen Species

2021 ◽  
Vol 17 (12) ◽  
pp. 2420-2432
Author(s):  
Shichen Xie ◽  
Jingyao Zhu ◽  
Dicheng Yang ◽  
Yan Xu ◽  
Jun Zhu ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Zinc Oxide ◽  
Zno Nanoparticles ◽  
Reactive Oxygen ◽  
Alveolar Epithelial Cells ◽  
Oxygen Species ◽  
Dipalmitoyl Phosphatidylcholine ◽  
Alveolar Epithelial ◽  
Low Concentrations

With wide application of Zinc oxide (ZnO) nanoparticles, their biological toxicity has received more and more attention in recent years. In this research, two ZnO dispersions with different particle sizes, small size Zinc oxide (S-ZnO) and big size Zinc oxide (B-ZnO), were prepared using polycarboxylic acid as dispersant. We found that the S-ZnO nanoparticles showed stronger toxicity on Human Pulmonary Alveolar Epithelial Cells (HPAEpiC) under same concentration. Only 9 ppm S-ZnO could decrease HPAEpiC viability to about 50%, which means that, a small amount of well-dispersed ZnO nanoparticles in industrial production process may cause serious damage to the human body through oral inhalation. Focusing on mechanism for cytotoxicity, ZnO nanoparticles promoted generation and accumulation of Reactive Oxygen Species (ROS) in mitochondria via inhibiting Superoxide Dismutase (SOD) enzyme activity and reducing Glutathione (GSH) content. ROS in turn opened the mitochondrial Ca2+ pathway and lowered the Mitochondrial Membrane Potentials (MMP), leading to cell death. To simulate the lung environment in vitro, mixed dipalmitoyl phosphatidylcholine (DPPC) and ZnO nanoparticles (1:1) were incubated for 72 hours and then cytotoxicity was evaluated on HPAEpiC. Results showed that the cell viability was significantly increased, which proved that the DPPC effectively inhibited the toxicity of ZnO nanoparticles.

The role of l-cysteine and introduced surface defects in reactive oxygen species generation by ZnO nanoparticles

2018 ◽  
Vol 47 (25) ◽  
pp. 8320-8329 ◽  
Author(s):  
Dominika Wawrzyńczyk ◽  
Bartłomiej Cichy ◽  
Wiesław Stęk ◽  
Marcin Nyk
Keyword(s):  
Reactive Oxygen Species ◽  
Surface Functionalization ◽  
Zno Nanoparticles ◽  
Surface Defects ◽  
Reactive Oxygen Species Generation ◽  
Reactive Oxygen ◽  
Oxygen Species

The synthesis and surface functionalization of ZnO nanoparticles were performed, with attention being paid to the possible bio-related applications in light-triggered reactive oxygen species generation.

Influence of surface chemistry on the formation of a protein corona on nanodiamonds

2019 ◽  
Vol 7 (21) ◽  
pp. 3383-3389 ◽  
Author(s):  
Alfonso E. Garcia-Bennett ◽  
Arun Everest-Dass ◽  
Irene Moroni ◽  
Ishan Das Rastogi ◽  
Lindsay M. Parker ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Molecular Weight ◽  
Surface Chemistry ◽  
Cell Viability ◽  
Reactive Oxygen ◽  
Protein Corona ◽  
Low Molecular Weight ◽  
Oxygen Species ◽  
Low Molecular Weight Proteins

The protein corona of nanodiamonds is dominated by low molecular weight proteins and is largely independent of surface chemistry. The pre-incubation of nanodiamonds in serum and the formation of a protein corona decrease the production of reactive oxygen species, increasing the cell viability of macrophages.

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