scholarly journals Serum Human Epididymis Protein 4 is a Potential Biomarker for Early Chronic Kidney Disease in an Obese Population [Retraction]

2021 ◽  
Vol Volume 14 ◽  
pp. 4179-4180
Author(s):  
Shubo Tan ◽  
Yongmao Zeng ◽  
Shiliang Kuang ◽  
Jianjun Li
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Human Epididymis Protein 4 ◽  
Human Epididymis ◽  
Potential Biomarker ◽  
Obese Population

Elevated human epididymis protein 4 concentrations in chronic kidney disease

2012 ◽  
Vol 49 (4) ◽  
pp. 377-380 ◽  
Author(s):  
B. Nagy ◽  
Z. T. Krasznai ◽  
H. Balla ◽  
M. Csoban ◽  
P. Antal-Szalmas ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Human Epididymis Protein 4 ◽  
Human Epididymis

Cystatin C provides a better estimate of the effect of glomerular filtration rate on serum human epididymis protein 4 concentrations

2016 ◽  
Vol 54 (10) ◽  
Author(s):  
Simona Ferraro ◽  
Sara Pasqualetti ◽  
Assunta Carnevale ◽  
Mauro Panteghini
Keyword(s):  
Chronic Kidney Disease ◽  
Glomerular Filtration Rate ◽  
Glomerular Filtration ◽  
Cystatin C ◽  
Filtration Rate ◽  
Serum Concentrations ◽  
Glomerular Function ◽  
Human Epididymis Protein 4 ◽  
Disease Epidemiology ◽  
Human Epididymis

AbstractBackground:We evaluated the effect of kidney glomerular function on serum concentrations of human epididymis protein 4 (HE4) using creatinine (Cr), cystatin C (CysC) and related chronic kidney disease epidemiology collaboration (CKD-EPI) equations.Methods:We enrolled 101 women aged ≤56 years with a glomerular filtration rate (GFR) (estimated by CKD-EPI eGFRResults:A statistically significant increase in HE4 median concentrations was detected in subjects with an eGFRConclusions:Our study shows that a better estimate of the effect of GFR on serum HE4 is obtained by measuring CysC in serum or using CKD-EPI eGFR

P0868ZONULIN AS A THERAPEUTIC POTENTIAL BIOMARKER OF ANEMIA IN PATIENTS WITH MULTIPLE MYELOMA AND CHRONIC KIDNEY DISEASE

2020 ◽  
Vol 35 (Supplement_3) ◽  
Author(s):  
Karolina Woziwodzka ◽  
Jolanta Malyszko ◽  
Małgorzata Banaszkiewicz ◽  
Ewa Koc- Żorawska ◽  
Paulina Dumnicka ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Multiple Myeloma ◽  
Kidney Disease ◽  
Iron Status ◽  
P Value ◽  
Blood Collection ◽  
Serum Concentrations ◽  
Monoclonal Protein ◽  
Blood Hemoglobin ◽  
Potential Biomarker

Abstract Background and Aims Zonulin is a haptoglobin 2 precursor, that regulates the intestinal permeability. As a double-chain form it takes part in scavenging haemoglobin. Chronic inflammation is common complication of chronic kidney disease which affects iron metabolism. The most frequent manifestation of multiple myeloma is anaemia in up to 73% of patients. Serum concentrations of zonulin are associated with inflammation process, age, kidney failure and iron status and anaemia. The aim of the study was to analyse zonulin as a marker of anaemia in MM patients and investigate its relationship with acclaimed parameters of renal failure, inflammation, bone metabolism and stages of MM. Method The studied group of seventy-three patients with MM (67 symptomatic, 6 smoldering) included 35 women and 38 man, with mean age 69 ± 10 years. Median (IQR) of time from initial MM diagnosis was 36 (17; 69) months. Forty patients were in ISS stage 1, 15 in stage 2, and 12 in stage 3 at the time of blood collection. Remission of MM was diagnosed in 52 patients and stable or progressive disease in 21. Twenty-six patients had eGFR <60 ml/min/1.73 m2. The examined parameters included creatinine, urea, serum monoclonal protein, albumin, ferritin, blood hemoglobin and NT-proBNP. The association between zonulin, markers of MM stages and renal and bone markers were determined by the Pearson's test and multivariate stepwise regression analysis. The p-value <0.05 was considered statistically significant. Results Median (IQR) serum zonulin in the studied group was 23.9 (19.9; 27.4) ng/ml. There were no differences in zonulin concentrations between patients with smoldering versus symptomatic MM (p=0.4), with ISS 1 to 3 (p=0.7), with remission versus stable or progressive MM (p=0.9), or with eGFR <60 ml/min/1.73 m2 versus those with higher eGFR (p=0.6). Also, zonulin did not differ between subjects with and without anemia (Hb< the lower reference limit) (p=0.4). In whole studied group, significant correlations were observed between zonulin and serum albumin (R=0.30; p=0.009), creatinine (R=-0.28; p=0.018), eGFR (R=0.26; p=0.025), ferritin (R=0.34; p=0.013), NT-proBNP (R=-0.32; p=0.006). Moreover, in patients with symptomatic MM, zonulin correlated with monoclonal protein in serum (R=-0.29; p=0.046), blood hemoglobin (R=0.27; p=0.027), and age (R=-0.24; p=0.044). In multiple regression, serum concentrations of monoclonal protein (beta=-0.48 ± 0.16; p=0.006) and ferritin (beta=0.34 ± 0.14; p=0.023) as well as ISS stage 3 (beta=0.40 ± 0.18; p=0.034) were identified as independent predictors of zonulin concentrations. Conclusion Zonulin as a biomarker may promote diagnosis of etiology and management of MM-associated anaemia, which can contribute to biomarker-targeted therapeutic interventions. Early treatment may result in improved life expectancy in patients with MM and increase their quality of life.

scholarly journals Salivary Biomarkers of Oxidative Stress in Children with Chronic Kidney Disease

2018 ◽  
Vol 7 (8) ◽  
pp. 209 ◽  
Author(s):  
Mateusz Maciejczyk ◽  
Julita Szulimowska ◽  
Anna Skutnik ◽  
Katarzyna Taranta-Janusz ◽  
Anna Wasilewska ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Oxidative Damage ◽  
Diagnostic Value ◽  
Redox Status ◽  
Stress Index ◽  
Antioxidant Systems ◽  
Control Group ◽  
Potential Biomarker

There are still missing non-invasive biomarkers of chronic kidney disease (CKD) in children. Therefore, the aim of the study was to evaluate oxidative stress indicators in the non-stimulated (NWS) and stimulated saliva (SWS) of CKD children (n = 25) and healthy controls (n = 25). Salivary antioxidants (catalase (CAT), peroxidase (Px), superoxide dismutase (SOD), uric acid (UA), reduced glutathione (GSH), albumin), redox status (total antioxidant capacity (TAC), total oxidant status (TOS), oxidative stress index (OSI)), and oxidative damage products (advanced glycation end products (AGE), advanced oxidation protein products (AOPP), malondialdehyde (MDA)) were evaluated. We have demonstrated the significantly higher activity of SWS GPx and SOD, as well as elevated concentrations of UA and albumin in NWS and SWS of CKD children vs. the control group. TAC, TOS and OSI were significantly higher only in SWS, while oxidative damage products (AGE, AOPP and MDA) were significantly higher in both NWS and SWS of CKD children. ROC analysis showed a considerably high diagnostic value of AOPP in both NWS and SWS of CKD children compared to controls (AUC = 0.92; 0.98). CKD is responsible for disturbances in salivary antioxidant systems and oxidative damage to proteins and lipids. Salivary AOPP can be a potential biomarker of CKD in children.

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