scholarly journals Human Epididymis Protein 4: A Novel Biomarker for Lupus Nephritis and Chronic Kidney Disease in Systemic Lupus Erythematosus

2016 ◽  
Vol 30 (6) ◽  
pp. 897-904 ◽  
Author(s):  
Zaixing Yang ◽  
Zhiyu Zhang ◽  
Baodong Qin ◽  
Ping Wu ◽  
Renqian Zhong ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Lupus Nephritis ◽  
Lupus Erythematosus ◽  
Systemic Lupus ◽  
Human Epididymis Protein 4 ◽  
Human Epididymis

P35 Prevalence of chronic kidney disease in patients with juvenile systemic lupus erythematosus: a single centre study

Rheumatology ◽  
2019 ◽  
Vol 58 (Supplement_4) ◽  
Author(s):  
Yasmin Mahfouz ◽  
Anastasia-Vasiliki Madenidou ◽  
Coziana Ciurtin
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Lupus Nephritis ◽  
Lupus Erythematosus ◽  
Conflicts Of Interest ◽  
Moderate Correlation ◽  
Systemic Lupus ◽  
Single Centre ◽  
Baseline Characteristics

Abstract Background Systemic lupus erythematosus (SLE) is a systemic autoimmune/inflammatory disorder that can affect any organ system. An estimated 10- 20% of all patients with SLE develop clinical disease before the age of 16 years and are therefore classified as juvenile-onset SLE (JSLE). JSLE is characterised by more severe clinical manifestations, such as lupus nephritis, more complications and less favourable outcomes compared to adult-onset SLE. Chronic kidney disease (CKD) refers to a state of irreversible kidney damage and/or reduction of kidney function that is associated with progressive loss of function over time. Lupus nephritis does not always lead to CKD. However, when it does it is associated with increased morbidity and mortality. It is important to identify clinical and laboratory predictors of CKD development in JSLE patients, as a more aggressive treatment approach could be advocated for these patients. In this study we compared the baseline characteristics of JSLE patients with and without chronic kidney disease to ascertain if there are any significant differences between the two groups. Methods This is a single-centre retrospective study, who included patients reviewed in our young adult and adolescent clinics. All data were analysed descriptively. Mann-Whitney U or Chi-Square tests were performed to compare the characteristics between the patients with and without CKD. We used the Pearson’s (r) or Kendall’s τ (tau) correlation to examine if there is any association between the CKD and the baseline characteristics. Results We identified 44 JSLE patients, out of which 17 (39%) fulfilled the diagnostic criteria for CKD at their last clinical review. The stages of CKD varied from 2 to 5. All patients with CKD also had lupus nephritis, while 5/44 patients (11%) had lupus nephritis without CKD. There were statistical significant differences in the treatments used for patients with and without CKD. As expected, the highest dsDNAlevels were higher in patients with CKD (p = 0.03). There was also a positive moderate correlation (ρ = 0.32) between raised levels of dsDNAand the development of CKD (p = 0.008). We also found a negative moderate correlation (τ= -0.439) between the presence of RF and CKD (p = 0.04). Conclusion We found a negative moderate correlation between the presence of RF and CKD, which has also been reported in the literature before. Further research using a large JSLE cohort is suggested to explore further if RF exerts a protective effect against renal disease in SLE. dsDNA is a serological marker of lupus nephritis and it is reasonable that the highest dsDNA correlates with CKD. Conflicts of Interest The authors declare no conflicts of interest.

Characteristics of lupus and lupus nephritis at a tertiary care center in Lebanon

Lupus ◽  
2019 ◽  
Vol 28 (13) ◽  
pp. 1598-1603 ◽  
Author(s):  
S H Koubar ◽  
J Kort ◽  
S Kawtharani ◽  
M Chaaya ◽  
M Makki ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Kidney Disease ◽  
Complete Remission ◽  
Lupus Nephritis ◽  
Lupus Erythematosus ◽  
Partial Remission ◽  
Care Center ◽  
Tertiary Care ◽  
Tertiary Care Center ◽  
Systemic Lupus

Introduction Systemic lupus erythematosus affects 4.8–78.5 people per 100,000 worldwide, 90% of whom are females. Geography and ethnicity have been shown to significantly affect the prevalence and natural history of the disease. Lupus nephritis affects around half of patients with systemic lupus erythematosus. Data about systemic lupus erythematosus and lupus nephritis in the Middle East are still scarce. In this study, we aimed to describe the characteristics of systemic lupus erythematosus and lupus nephritis at a tertiary care center in Lebanon. Methods This is a retrospective chart review of all biopsy-proven lupus nephritis patients admitted to the American University of Beirut medical center between January 2000 and December 2018. Patients above 12 years of age who had any International Society of Nephrology/Renal Pathology Society (ISN/RPS) class of lupus nephritis on their renal biopsy were included in the study. Results The study included 55 patients with lupus nephritis. Upon presentation of systemic lupus erythematosus, the most common clinical feature was arthritis, seen in 83% of patients, followed by anemia (82%) and malar rash (48%). In total 93% had positive ANA, 89% had positive anti-dsDNA and 98% of patients had proteinuria. The most common ISN/RPS class of lupus nephritis in our series was IV (49%). At the time of the biopsy 15% of patients underwent dialysis. At 6 months, 11/27 had complete remission, 6/27 had partial remission and 10/27 had no remission. At 1 year, 8/23 had complete remission, 4/23 had partial remission and 11/23 had no remission. During the study period, 15 out of 35 patients available for analysis had chronic kidney disease (CKD) and six out of 34 patients developed end-stage kidney disease requiring renal replacement therapy. In comparison to other series in the region, our series had more males affected, higher creatinine at the time of biopsy and greater degree of proteinuria. Conclusion Our study provided insight on the demographics, characteristics, and outcomes of lupus nephritis in Lebanon. Interestingly, male gender was present in a quarter of patients. This warrants further investigation and confirmation. We are hoping to expand this experience into a national prospective registry to further characterize this entity in our region.

scholarly journals Severity and clinical causes of chronic kidney disease among outpatients from selected hospitals in Nairobi County, Kenya

2021 ◽  
Vol 8 (10) ◽  
pp. 4720
Author(s):  
Annastacia N. Mbithi ◽  
Harun M. Kimani ◽  
Alloys S. S. Orago
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Chronic Kidney Disease ◽  
Diabetic Nephropathy ◽  
Kidney Disease ◽  
Clinical Features ◽  
Lupus Erythematosus ◽  
Severe Disease ◽  
Polycystic Kidney ◽  
Systemic Lupus ◽  
Hypertensive Nephrosclerosis

Background: Chronic kidney disease (CKD) is a worldwide public health issue with high prevalence (8% and 16%) among adults. The severity of CKD and associated clinical features are less characterized in Kenya. We set to determine severity and clinical features of CKD among outpatient attendees in selected hospitals in Nairobi county.Methods: In this hospital based analytical cross-sectional study design, we collected data from Kenyatta National Hospital (KNH), Aga Khan University Hospital (AKUHN) and Mater Misericordiae Hospital. We recruited 336 adult CKD outpatients aged 18 years and above attending nephrology clinics between January and July, 2020 using a simple random sampling. A self-administered questionnaire was used to collect social-demographic data while data on severity and clinical features were retrieved from patient’s files of those who had given an informed consent. Descriptive and inferential statistics were performed using statistical package of social science version 26.0.Results: Majority of CKD patients (61.9%) had severe disease. Among patients with CKD, the following clinical features were statistically significant with severe disease; diabetic nephropathy (OR 3.43, 95% CI; 1.72, 5.67), glomerulonephritis (OR 2.52, 95% CI; 2.07, 4.05), hypertensive nephrosclerosis (OR 1.95, 95% CI; 1.87, 3.11), polycystic kidney disease (OR 1.26, 95% CI; 1.12, 2.61) and systemic lupus erythematosus (OR 1.16, 95% CI; 1.06, 1.39).Conclusions: Among outpatient attendees in Nairobi county, severe CKD is likely to be found in patients with diabetic nephropathy, glomerulonephritis, hypertensive nephrosclerosis, polycystic kidney disease and systemic lupus erythematosus. Therefore, the patients with these features need proper follow up and treatment to slow down progression of CKD to severe stages. However, more studies are need to be done to ascertain that the clinical features are responsible for severe CKD.  

scholarly journals Association of soluble CD40 levels with ‐1 C > T CD40 polymorphism and chronic kidney disease in systemic lupus erythematosus

2019 ◽  
Vol 7 (12) ◽  
Author(s):  
Raziel Tapia‐Llanos ◽  
José F. Muñoz‐Valle ◽  
Ilce V. Román‐Fernández ◽  
Miguel Marín‐Rosales ◽  
Diana C. Salazar‐Camarena ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Lupus Erythematosus ◽  
Systemic Lupus

scholarly journals THU0270  THE BURDEN OF CHRONIC KIDNEY DISEASE IN SYSTEMIC LUPUS ERYTHEMATOSUS: A NATIONWIDE EPIDEMIOLOGIC STUDY

2019 ◽  
Author(s):  
Arthur Mageau ◽  
Jean-Francois Timsit ◽  
Anne Perozziello ◽  
Benedicte Giroux Leprieur ◽  
Stephane Ruckly ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Lupus Erythematosus ◽  
Epidemiologic Study ◽  
Systemic Lupus

scholarly journals Hydroxychloroquine is neutral in risk of chronic kidney disease in patients with systemic lupus erythematosus

2020 ◽  
pp. annrheumdis-2020-217728
Author(s):  
Chia-Ying Wu ◽  
Magdalene Tan ◽  
Jing-Yang Huang ◽  
Jeng-Yuan Chiou ◽  
James Cheng-Chung Wei
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Lupus Erythematosus ◽  
Systemic Lupus

scholarly journals Cistatina C: Um Marcador de Função Renal Promissor em Doentes com Lúpus Eritematoso Sistémico?

2015 ◽  
Vol 28 (3) ◽  
pp. 333 ◽  
Author(s):  
Lígia Peixoto ◽  
Patrício Aguiar ◽  
Raquel De Bragança ◽  
Joana Rosa Martins ◽  
Alba Janeiro Acabado ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Chronic Kidney Disease ◽  
Glomerular Filtration Rate ◽  
Kidney Disease ◽  
Glomerular Filtration ◽  
Cystatin C ◽  
Lupus Erythematosus ◽  
Filtration Rate ◽  
Systemic Lupus ◽  
Disease Epidemiology

<strong>Purpose:</strong> Cystatin C has a higher correlation with glomerular filtration rate and a more significant clinical prognosis than creatinine. We sought to determine whether it is a marker of renal function different from creatinine (cystatin C potentially superior to creatinine), in patients with systemic lupus erythematosus.<br /><strong>Material and Methods:</strong> 37 patients with systemic lupus erythematosus were evaluated. Serum cystatin C was determined by nephelometry and creatinine by modified Jaffe method. We compared five formulas: Chronic Kidney Disease – Epidemiology Collaboration cystiatin; Chronic Kidney Disease – Epidemiology Collaboration creatinine-cystatin; Cockcroft-Gault; Modification of Diet in Renal Disease and Chronic Kidney Disease – Epidemiology Collaboration creatinine, using the latter as a reference. We analyzed the influence of clinical and laboratory factors in cystatin C variation, using multivariate linear regression.<br /><strong>Results:</strong> Cystatin C was singly elevated in ten participants, versus none isolated creatinine elevation, and this difference was significant (p = 0.002). There was a difference between the estimated glomerular filtration rate by Chronic Kidney Disease – Epidemiology Collaboration cystatin and by Chronic Kidney Disease – Epidemiology Collaboration creatinine (-6.0541 mL/min/1.73 m2, p = 0.07), more pronounced for lower glomerular filtration rate. Consequently, Chronic Kidney Disease – Epidemiology Collaboration cystatin reclassified 4 patients as having chronic kidney disease de novo and 1 patient as not having chronic kidney disease (p = 0.375).<br />Cystatin C was only significantly influenced by age (p &lt; 0.001).<br /><strong>Discussion:</strong> Several reports showed cystatin C as a better marker to define chronic kidney disease, allowing more accurate classification and risk stratification, compared with creatinine. In this study, Cystatin C revealed as a promisor marker of renal function in patient with lupus, mainly in patients with lower glomerular filtration rates. The correlation between age and cystatin C seems to be a confounding<br />factor, as glomerular filtration rate physiologically declines with ageing.<br /><strong>Conclusion:</strong> Cystatin C was potentially superior to creatinine and in this study and cystatin C seems to detect changes in glomerular filtration rate earlier than creatinine and may be a better screening method for chronic kidney disease in systemic lupus erythematosus.

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