scholarly journals Current and emerging treatment options for ANCA-associated vasculitis: potential role of belimumab and other BAFF/APRIL targeting agents

2015 ◽  
pp. 333 ◽  
Author(s):  
Petar Lenert ◽  
Aleksander Lenert
Keyword(s):  
Potential Role ◽  
Treatment Options ◽  
Anca Associated Vasculitis

Platelets release proinflammatory microparticles in anti-neutrophil cytoplasmic antibody-associated vasculitis

Rheumatology ◽  
2019 ◽  
Vol 58 (8) ◽  
pp. 1432-1442 ◽  
Author(s):  
Di Miao ◽  
Tian-Tian Ma ◽  
Min Chen ◽  
Ming-Hui Zhao
Keyword(s):  
Renal Damage ◽  
Potential Role ◽  
Biological Functions ◽  
Active Stage ◽  
Array Analysis ◽  
Antibody Microarrays ◽  
Bioactive Proteins ◽  
Anca Associated Vasculitis ◽  
Proinflammatory Molecules

Abstract Objective The biological functions of the platelets contributing to ANCA-associated vasculitis (AAV) are largely unclear. The current study aimed to investigate the potential role of platelet-derived microparticles (PMPs) in AAV. Methods In the current study, microparticles in AAV patients were analysed by flow cytometry, and PMPs were probed for relative levels of 640 bioactive proteins secreted from patients’ platelets using antibody microarrays. These data were then correlated with clinical and pathological parameters. Results PMPs were significantly increased in 69 AAV patients, predominantly MPO-ANCA positive patients in active stage compared with in remission [4406.8/μl (2135.4, 5485.0) vs 549.7/μl (350, 708.5), P < 0.0001], and 43% of microparticles in active AAV were PMPs. Compared with 15 patients in remission, highly expressed proinflammatory molecules in the microparticles from platelets in 15 AAV patients in active stage revealed that potential functions of PMPs were promotion of the effect of chemotaxis, adhesion, growth and apoptosis (all the patients for array analysis were MPO-ANCA positive). The level of PMPs had a significant association with disease activity, inflammation, and renal damage. Conclusion PMPs may serve as inflammatory propagators through their wide production of proinflammatory cytokines in AAV, potentially providing a novel therapeutic target.

Psilocybin-assisted therapy for depression: How do we advance the field?

2019 ◽  
Vol 54 (3) ◽  
pp. 225-231 ◽  
Author(s):  
Sally E Meikle ◽  
Paul Liknaitzky ◽  
Susan L Rossell ◽  
Margaret Ross ◽  
Nigel Strauss ◽  
...  
Keyword(s):  
Side Effects ◽  
Adverse Effects ◽  
Potential Role ◽  
Treatment Options ◽  
Clinical Environment ◽  
Psychedelic Drugs ◽  
Key Issues ◽  
New Treatment ◽  
Potential Use

In the quest for new treatment options for depression, attention is being paid to the potential role of psychedelic drugs. Psilocybin is of particular interest given its mechanism of action, its benefits in early trials and its relatively low side effects burden. This viewpoint outlines a number of key issues that remain to be elucidated about its potential use in the clinical environment, including clarification of the profile of people most likely to benefit and those who might experience adverse effects, longer-term outcomes and the role of psychotherapeutic input alongside the drug itself. There are also opportunities to understand better, the neurobiology underpinning its effects.

Treatment options for diabetes: Potential role of stem cells

2012 ◽  
Vol 98 (3) ◽  
pp. 361-368 ◽  
Author(s):  
Jamil Stanekzai ◽  
Esma R. Isenovic ◽  
Shaker A. Mousa
Keyword(s):  
Stem Cells ◽  
Potential Role ◽  
Treatment Options

scholarly journals Prognostic value and the potential role of treatment options for cervical lymph node necrosis in nasopharyngeal carcinoma

Oral Oncology ◽  
2020 ◽  
Vol 109 ◽  
pp. 104864
Author(s):  
Kuiyuan Liu ◽  
Siting Lin ◽  
Liangru Ke ◽  
Weixiong Xia ◽  
Chun Zhang ◽  
...  
Keyword(s):  
Lymph Node ◽  
Nasopharyngeal Carcinoma ◽  
Cervical Lymph Node ◽  
Prognostic Value ◽  
Potential Role ◽  
Treatment Options

Staphylococcus epidermidis: A Potential New Player in the Physiopathology of Acne?

Dermatology ◽  
2019 ◽  
Vol 235 (4) ◽  
pp. 287-294 ◽  
Author(s):  
Jean-Paul Claudel ◽  
Nicole Auffret ◽  
Marie-Thérèse Leccia ◽  
Florence Poli ◽  
Stéphane Corvec ◽  
...  
Keyword(s):  
Human Skin ◽  
Staphylococcus Epidermidis ◽  
Skin Disease ◽  
Potential Role ◽  
Current Knowledge ◽  
Treatment Options ◽  
Skin Microbiome ◽  
Cutibacterium Acnes ◽  
Skin Commensals

Background: Cutibacterium acnes has been identified as one of the main triggers of acne. However, increasing knowledge of the human skin microbiome raises questions about the role of other skin commensals, such as Staphylococcus epidermidis, in the physiopathology of this skin disease. Summary: This review provides an overview of current knowledge of the potential role of S. epidermidis in the physiopathology of acne. Recent research indicates that acne might be the result of an unbalanced equilibrium between C. acnes and S. epidermidis,according to dedicated interactions. Current treatments act on C. acnesonly. Other treatment options may be considered, such as probiotics derived from S. epidermidis to restore the naturally balanced microbiota or through targeting the regulation of the host’s AMP mediators. Key Messages: Research seems to confirm the beneficial role of S. epidermidis in acne by limiting C. acnes over-colonisation and inflammation.

scholarly journals The Management of Infection and Colonization due to Methicillin-ResistantStaphylococcus aureus: A CIDS/CAMM Position Paper

2004 ◽  
Vol 15 (1) ◽  
pp. 39-48 ◽  
Author(s):  
Andrew E Simor ◽  
Mark Loeb ◽  
the CIDS/CAMM Guidelines Committee
Keyword(s):  
Staphylococcus Aureus ◽  
Potential Role ◽  
Antimicrobial Agents ◽  
Treatment Options ◽  
Position Paper ◽  
Health Care Facilities ◽  
Care Facilities ◽  
Life Threatening ◽  
Mrsa Infection

Methicillin-resistantStaphylococcus aureus(MRSA) is being seen with greater frequency in most hospitals and other health care facilities across Canada. The organism may cause life-threatening infections and has been associated with institutional outbreaks. Several studies have confirmed that MRSA infection is associated with increased morbidity and mortality compared with infections caused by susceptible strains, even when the presence of comorbidities is accounted for. Treatment of MRSA infection is complicated by the fact that these organisms are resistant to multiple antimicrobial agents, so treatment options are limited. The effectiveness of decolonization therapy (attempting to eradicate MRSA carriage) is also uncertain. This paper reviews the medical management of MRSA infections, discusses the potential role of decolonization and provides an overview of evidence to support recommended infection control practices.

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