scholarly journals Emerging treatment options for short bowel syndrome: potential role of teduglutide

2011 ◽  
pp. 189 ◽  
Author(s):  
Tee ◽  
Tee ◽  
Gabe ◽  
Katharina Wallis
Keyword(s):  
Short Bowel Syndrome ◽  
Potential Role ◽  
Treatment Options ◽  
Short Bowel

Short bowel syndrome: the role of GLP-2 on improving outcome

2009 ◽  
Vol 12 (5) ◽  
pp. 526-532 ◽  
Author(s):  
Katharina Wallis ◽  
Julian RF Walters ◽  
Simon Gabe
Keyword(s):  
Short Bowel Syndrome ◽  
Short Bowel

scholarly journals Short Bowel Syndrome: Review of Treatment Options

2017 ◽  
Author(s):  
Nina Oktavia Marfu'ah ◽  
Herry Purbayu ◽  
Iswan Abbas Nusi ◽  
Poernomo Boedi Setiawan ◽  
Titong Sugihartono ◽  
...  
Keyword(s):  
Short Bowel Syndrome ◽  
Treatment Options ◽  
Short Bowel

scholarly journals Distraction-Induced Intestinal Growth: The Role of Mechanotransduction Mechanisms in a Mouse Model of Short Bowel Syndrome

2013 ◽  
pp. 131106060201007 ◽  
Author(s):  
Ryo Sueyoshi ◽  
Kathleen M. Woods Ignatoski ◽  
Manabu Okawada ◽  
Daniel H. Teitelbaum
Keyword(s):  
Mouse Model ◽  
Short Bowel Syndrome ◽  
Intestinal Growth ◽  
Short Bowel

scholarly journals Surgical management of intestinal failure

2003 ◽  
Vol 62 (3) ◽  
pp. 711-718 ◽  
Author(s):  
G. L. Carlson
Keyword(s):  
Surgical Treatment ◽  
Short Bowel Syndrome ◽  
Surgical Management ◽  
Nutritional Support ◽  
Intestinal Failure ◽  
Short Bowel ◽  
Abdominal Infection ◽  
Intra Abdominal Infection ◽  
Acute Intestinal Failure

Surgery plays a key role in the management of both acute and, less frequently, chronic intestinal failure. Acute intestinal failure frequently requires surgical treatment when it arises as a consequence of intestinal fistulation or obstruction. In specialised clinical practice approximately 50% of acute intestinal failure is associated with intestinal fistulas and in approximately 50% of patients, this condition arises as part of the natural history or complicating treatment for Crohn's disease. A considerable proportion of such patients have abdominal infection and present complex nutritional and metabolic problems. The most important aspect of the surgical management of patients with acute intestinal failure associated with intra-abdominal infection is management of sepsis, since recovery is unlikely in the presence of active infection. Moreover, effective nutritional support and restoration of body composition is not possible if sepsis remains unresolved. Surgical strategies to deal with intra-abdominal infection may involve percutaneous drainage, laparotomy and resection of fistulating segments of intestine and, when infection is persistent and contamination extensive, laparostomy (a technique in which the abdomen is left open and allowed to heal by secondary intention). Surgical treatment should not only be timely and effective, but also aimed at preventing secondary damage to the small intestine, in order to minimise the risk of short bowel syndrome. In some cases a proximal defunctioning stoma may be required, with prolonged nutritional support, using either home total parenteral nutrition or feeding via the defunctioned distal gut (fistuloclysis), pending restoration of intestinal continuity. The role of surgical treatment for patients with short bowel syndrome is less clear. While surgery is frequently required for the management of complications of short bowel syndrome (including gallstones and possibly peptic ulcer disease), the role of intestinal lengthening and tapering procedures (to increase functional intestinal length), and artificial valves, reversed segments and colonic interposition (to reduce intestinal transit) remains controversial. For some patients with short bowel syndrome and, in particular, those with combined intestinal and hepatic failure, intestinal transplantation may become the treatment of choice as long-term results continue to improve.

Psilocybin-assisted therapy for depression: How do we advance the field?

2019 ◽  
Vol 54 (3) ◽  
pp. 225-231 ◽  
Author(s):  
Sally E Meikle ◽  
Paul Liknaitzky ◽  
Susan L Rossell ◽  
Margaret Ross ◽  
Nigel Strauss ◽  
...  
Keyword(s):  
Side Effects ◽  
Adverse Effects ◽  
Potential Role ◽  
Treatment Options ◽  
Clinical Environment ◽  
Psychedelic Drugs ◽  
Key Issues ◽  
New Treatment ◽  
Potential Use

In the quest for new treatment options for depression, attention is being paid to the potential role of psychedelic drugs. Psilocybin is of particular interest given its mechanism of action, its benefits in early trials and its relatively low side effects burden. This viewpoint outlines a number of key issues that remain to be elucidated about its potential use in the clinical environment, including clarification of the profile of people most likely to benefit and those who might experience adverse effects, longer-term outcomes and the role of psychotherapeutic input alongside the drug itself. There are also opportunities to understand better, the neurobiology underpinning its effects.

Role of bacteria in the pathogenesis of short bowel syndrome-associated D-lactic acidemia

1997 ◽  
Vol 22 (5) ◽  
pp. 285-293 ◽  
Author(s):  
G.P..A Bongaerts ◽  
J.J.M. Tolboom ◽  
A.H.J. Naber ◽  
W.J.K. Sperl ◽  
R.S.V.M. Severijnen ◽  
...  
Keyword(s):  
Short Bowel Syndrome ◽  
Short Bowel ◽  
Lactic Acidemia
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