scholarly journals The effect of a peptide-containing synthetic lung surfactant on gas exchange and lung mechanics in a rabbit model of surfactant depletion

2013 ◽  
pp. 139 ◽  
Author(s):  
Johann M van Zyl ◽  
Johan Smith ◽  
Hawtrey
Keyword(s):  
Gas Exchange ◽  
Lung Surfactant ◽  
Rabbit Model ◽  
Lung Mechanics ◽  
Surfactant Depletion

scholarly journals Derecruitment Test and Surfactant Therapy in Patients with Acute Lung Injury

2012 ◽  
Vol 2012 ◽  
pp. 1-6
Author(s):  
Alexey A. Smetkin ◽  
Vsevolod V. Kuzkov ◽  
Konstantin M. Gaidukov ◽  
Lars J. Bjertnaes ◽  
Mikhail Y. Kirov
Keyword(s):  
Acute Lung Injury ◽  
Gas Exchange ◽  
Lung Injury ◽  
Predictive Value ◽  
Conventional Therapy ◽  
Therapy Group ◽  
Lung Mechanics ◽  
Lung Water ◽  
Mechanically Ventilated ◽  
Water Index

Introduction. A recruitment maneuver (RM) may improve gas exchange in acute lung injury (ALI). The aim of our study was to assess the predictive value of a derecruitment test in relation to RM and to evaluate the efficacy of RM combined with surfactant instillation in patients with ALI.Materials and Methods. Thirteen adult mechanically ventilated patients with ALI were enrolled into a prospective pilot study. The patients received protective ventilation and underwent RM followed by a derecruitment test. After a repeat RM, bovine surfactant (surfactant group,n=6) or vehicle only (conventional therapy group,n=7) was instilled endobronchially. We registered respiratory and hemodynamic parameters, including extravascular lung water index (EVLWI).Results. The derecruitment test decreased the oxygenation in 62% of the patients. We found no significant correlation between the responses to the RM and to the derecruitment tests. The baseline EVLWI correlated with changes in SpO2following the derecruitment test. The surfactant did not affect gas exchange and lung mechanics but increased EVLWI at 24 and 32 hrs.Conclusions. Our study demonstrated no predictive value of the derecruitment test regarding the effects of RM. Surfactant instillation was not superior to conventional therapy and might even promote pulmonary edema in ALI.

Effect of the mode of extrapulmonary gas exchange on lung surfactant function and metabolism

1987 ◽  
Vol 104 (1) ◽  
pp. 886-888
Author(s):  
V. I. Skorik ◽  
E. V. Perezhogin ◽  
R. G. Parnova ◽  
B. M. Zelikson ◽  
T. M. Malikova ◽  
...  
Keyword(s):  
Gas Exchange ◽  
Lung Surfactant

Sustained improvement of gas exchange and lung mechanics by vaporized perfluorocarbon inhalation in piglet acute lung injury model

2013 ◽  
Vol 8 (2) ◽  
pp. 160-166 ◽  
Author(s):  
Xiaoguang Wang ◽  
Jianpeng Zhang ◽  
Xiaoling Li ◽  
Youning Liu ◽  
Haibo Yang ◽  
...  
Keyword(s):  
Acute Lung Injury ◽  
Gas Exchange ◽  
Lung Injury ◽  
Lung Mechanics ◽  
Sustained Improvement ◽  
Injury Model ◽  
Lung Injury Model

Persistent Improvement of Gas Exchange and Lung Mechanics by Aerosolized Perfluorocarbon

2001 ◽  
Vol 164 (1) ◽  
pp. 31-35 ◽  
Author(s):  
MICHAEL A. KANDLER ◽  
KATHARINA von der HARDT ◽  
ELLEN SCHOOF ◽  
JÖRG DÖTSCH ◽  
WOLFGANG RASCHER
Keyword(s):  
Gas Exchange ◽  
Lung Mechanics
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