Sustained improvement of gas exchange and lung mechanics by vaporized perfluorocarbon inhalation in piglet acute lung injury model

2013 ◽  
Vol 8 (2) ◽  
pp. 160-166 ◽  
Author(s):  
Xiaoguang Wang ◽  
Jianpeng Zhang ◽  
Xiaoling Li ◽  
Youning Liu ◽  
Haibo Yang ◽  
...  
Keyword(s):  
Acute Lung Injury ◽  
Gas Exchange ◽  
Lung Injury ◽  
Lung Mechanics ◽  
Sustained Improvement ◽  
Injury Model ◽  
Lung Injury Model

scholarly journals Effect of pentoxifylline on lung inflammation and gas exchange in a sepsis-induced acute lung injury model

2006 ◽  
Vol 39 (11) ◽  
pp. 1455-1463 ◽  
Author(s):  
I.S. Oliveira-Junior ◽  
M.K.C. Brunialti ◽  
I.H.J. Koh ◽  
V.B.C. Junqueira ◽  
R. Salomão
Keyword(s):  
Acute Lung Injury ◽  
Gas Exchange ◽  
Lung Injury ◽  
Lung Inflammation ◽  
Injury Model ◽  
Lung Injury Model

PULMONARY FIBROBLAST FUNCTION IN AN ACUTE LUNG INJURY MODEL

1994 ◽  
Vol 37 (1) ◽  
pp. 156
Author(s):  
Andrew Mikulaschek ◽  
Stantey Z Trooskin ◽  
Allen Nonn ◽  
Jason Winfield
Keyword(s):  
Acute Lung Injury ◽  
Lung Injury ◽  
Injury Model ◽  
Lung Injury Model ◽  
Pulmonary Fibroblast

Derivation of recruitment function from the pressure–volume curve in an acute lung injury model

2015 ◽  
Vol 205 ◽  
pp. 16-20 ◽  
Author(s):  
Yoshihiro Uzawa ◽  
Mikiya Otsuji ◽  
Koichi Nakazawa ◽  
Wei Fan ◽  
Yoshitsugu Yamada
Keyword(s):  
Acute Lung Injury ◽  
Lung Injury ◽  
Volume Curve ◽  
Pressure Volume Curve ◽  
Injury Model ◽  
Lung Injury Model

AIRWAY PRESSURE RELEASE VENTILATION (APRV) IN A PEDIATRIC ACUTE LUNG INJURY MODEL

1990 ◽  
Vol 18 (Supplement) ◽  
pp. S231 ◽  
Author(s):  
Lynn D. Martin ◽  
Anthony L. Bilenki ◽  
James F. Rafferty ◽  
Randall C. Wetzel
Keyword(s):  
Acute Lung Injury ◽  
Lung Injury ◽  
Airway Pressure ◽  
Airway Pressure Release Ventilation ◽  
Pressure Release ◽  
Injury Model ◽  
Lung Injury Model ◽  
Pressure Release Ventilation

scholarly journals Derecruitment Test and Surfactant Therapy in Patients with Acute Lung Injury

2012 ◽  
Vol 2012 ◽  
pp. 1-6
Author(s):  
Alexey A. Smetkin ◽  
Vsevolod V. Kuzkov ◽  
Konstantin M. Gaidukov ◽  
Lars J. Bjertnaes ◽  
Mikhail Y. Kirov
Keyword(s):  
Acute Lung Injury ◽  
Gas Exchange ◽  
Lung Injury ◽  
Predictive Value ◽  
Conventional Therapy ◽  
Therapy Group ◽  
Lung Mechanics ◽  
Lung Water ◽  
Mechanically Ventilated ◽  
Water Index

Introduction. A recruitment maneuver (RM) may improve gas exchange in acute lung injury (ALI). The aim of our study was to assess the predictive value of a derecruitment test in relation to RM and to evaluate the efficacy of RM combined with surfactant instillation in patients with ALI.Materials and Methods. Thirteen adult mechanically ventilated patients with ALI were enrolled into a prospective pilot study. The patients received protective ventilation and underwent RM followed by a derecruitment test. After a repeat RM, bovine surfactant (surfactant group,n=6) or vehicle only (conventional therapy group,n=7) was instilled endobronchially. We registered respiratory and hemodynamic parameters, including extravascular lung water index (EVLWI).Results. The derecruitment test decreased the oxygenation in 62% of the patients. We found no significant correlation between the responses to the RM and to the derecruitment tests. The baseline EVLWI correlated with changes in SpO2following the derecruitment test. The surfactant did not affect gas exchange and lung mechanics but increased EVLWI at 24 and 32 hrs.Conclusions. Our study demonstrated no predictive value of the derecruitment test regarding the effects of RM. Surfactant instillation was not superior to conventional therapy and might even promote pulmonary edema in ALI.

scholarly journals Effects of nebulized antithrombin and heparin on inflammatory and coagulation alterations in an acute lung injury model in rats

2019 ◽  
Vol 18 (3) ◽  
pp. 571-583 ◽  
Author(s):  
Marta Camprubí‐Rimblas ◽  
Neus Tantinyà ◽  
Raquel Guillamat‐Prats ◽  
Josep Bringué ◽  
Ferranda Puig ◽  
...  
Keyword(s):  
Acute Lung Injury ◽  
Lung Injury ◽  
Injury Model ◽  
Lung Injury Model

scholarly journals Levonadifloxacin, a Novel Benzoquinolizine Fluoroquinolone, Modulates Lipopolysaccharide-Induced Inflammatory Responses in Human Whole-Blood Assay and Murine Acute Lung Injury Model

2020 ◽  
Vol 64 (5) ◽  
Author(s):  
Anasuya Patel ◽  
Ganesh V. Sangle ◽  
Jinal Trivedi ◽  
Sushant A. Shengule ◽  
Deepak Thorve ◽  
...  
Keyword(s):  
Acute Lung Injury ◽  
Lung Injury ◽  
Whole Blood ◽  
Inflammatory Responses ◽  
Immunomodulatory Activity ◽  
Human Whole Blood ◽  
Injury Model ◽  
Cytokine Levels ◽  
Lung Injury Model ◽  
Clinical Benefits

ABSTRACT Fluoroquinolones are reported to possess immunomodulatory activity; hence, a novel benzoquinolizine fluoroquinolone, levonadifloxacin, was evaluated in lipopolysaccharide-stimulated human whole-blood (HWB) and mouse acute lung injury (ALI) models. Levonadifloxacin significantly mitigated the inflammatory responses in an HWB assay through inhibition of proinflammatory cytokines and in the ALI model by lowering lung total white blood cell count, myeloperoxidase, and cytokine levels. The immunomodulatory effect of levonadifloxacin, along with promising antibacterial activity, is expected to provide clinical benefits in the treatment of infections.

Sign in / Sign up

Export Citation Format

Share Document