Lung mechanics and gas exchange in ventilated preterm infants during treatment of hyaline membrane disease with multiple doses of artificial surfactant (Exosurf)

1992 ◽  
Vol 14 (1) ◽  
pp. 10-15 ◽  
Author(s):  
Jürg Pfenninger ◽  
Christoph Aebi ◽  
Denis Bachrnann ◽  
Bendicht Peter Wagner
Keyword(s):  
Gas Exchange ◽  
Preterm Infants ◽  
Hyaline Membrane Disease ◽  
Lung Mechanics ◽  
Multiple Doses ◽  
Hyaline Membrane ◽  
Artificial Surfactant

Early and Late Surfactant Treatments in Baboon Model of Hyaline Membrane Disease

PEDIATRICS ◽  
1988 ◽  
Vol 81 (2) ◽  
pp. 277-283
Author(s):  
Haruo Maeta ◽  
Dharmapuri Vidyasagar ◽  
Tonse N. K. Raju ◽  
Rama Bhat ◽  
Hiroo Matsuda
Keyword(s):  
Comparison Group ◽  
Disease Model ◽  
Hyaline Membrane Disease ◽  
Lung Mechanics ◽  
Surfactant Therapy ◽  
Optimal Time ◽  
Treatment Groups ◽  
Baboon Model ◽  
Hyaline Membrane ◽  
Artificial Surfactant

Because the issue of optimal time for artificial surfactant therapy for hyaline membrane disease has not been established, the effects of treatment with a reconstituted bovine surfactant (surfactant TA) were compared at two time periods in a hyaline membrane disease model in a premature baboon. The baboons were delivered by cesarian section at 75% of gestation (139.5 ± 1.5 days, mean ± SD). One group was treated with surfactant TA within ten minutes after birth (ultraearly), another group was treated at two hours of age (late) and a third (comparison group) did not receive the surfactant. Both treatment groups had significantly higher compliance and ratio of arterial to alveolar Po2 ratio and lower mean airway pressure and oxygen requirement (Fio2) than the comparison group. At autopsy, the largest residual volume and hysteresis in pulmonary pressure-volume curves were noted in the ultraearly group, intermediate values were found in the late group, and least values were found in the comparison group. These data indicate that early surfactant therapy for hyaline membrane disease results in greater improvement in lung mechanics than delaying treatment, even for two hours. Delivery room treatment with surfactant of infants at risk for hyaline membrane disease is perhaps better than therapy for established hyaline membrane disease.

Effect of Low-Dose Dopamine Infusion on Prolactin and Thyrotropin Secretion in Preterm Infants with Hyaline Membrane Disease

Neonatology ◽  
1985 ◽  
Vol 47 (6) ◽  
pp. 317-322 ◽  
Author(s):  
I. Sen ◽  
T. Tulassay ◽  
J. Kiszel ◽  
F. Ruppert ◽  
E. Sulyok ◽  
...  
Keyword(s):  
Preterm Infants ◽  
Low Dose ◽  
Hyaline Membrane Disease ◽  
Dopamine Infusion ◽  
Hyaline Membrane

Hyaline Membrane Disease Treated with Bovine Surfactant

PEDIATRICS ◽  
1983 ◽  
Vol 71 (6) ◽  
pp. 913-917
Author(s):  
J. A. Smyth ◽  
I. L. Metcalfe ◽  
P. Duffty ◽  
F. Possmayer ◽  
M. H. Bryan ◽  
...  
Keyword(s):  
Preterm Infants ◽  
Bronchopulmonary Dysplasia ◽  
Oxygen Therapy ◽  
Hyaline Membrane Disease ◽  
Variable Degree ◽  
Arterial Oxygenation ◽  
Hyaline Membrane

Six preterm infants with severe hyaline membrane disease requiring ventilation were treated, at a median age of 15.5 hours, with a single intratracheal bolus of a bovine surfactant suspension. Arterial oxygenation increased dramatically, and chest radiograms showed improvement after two to four hours. However, a variable degree of deterioration occurred within 24 hours. All of the infants required oxygen therapy for several weeks, and one developed severe bronchopulmonary dysplasia.

On Replacing the Surfactant

PEDIATRICS ◽  
1980 ◽  
Vol 65 (6) ◽  
pp. 1176-1177
Author(s):  
Mary Ellen Avery
Keyword(s):  
Endotracheal Tube ◽  
Blood Gases ◽  
Hyaline Membrane Disease ◽  
Surfactant Deficiency ◽  
Hyaline Membrane ◽  
Surface Active ◽  
Artificial Surfactant ◽  
Patent Ductus

Ever since it was realized that hyaline membrane disease was the consequence of surfactant deficiency, replacing the missing surface-active alveolar lining layer has been a tantalizing prospect. The report of Fujiwara et al1 is the first demonstration in the human of consistent and dramatic success after a single instillation of an artificial surfactant by way of an endotracheal tube. The prompt restoration of a stable alveolar lining layer and the impressive improvement in blood gases are well documented. The problem of the widely patent ductus producing difficulties in the subsequent days is expected and of course could be approached by other interventions.

Continuous Tracheal Gas Insufflation in Preterm Infants with Hyaline Membrane Disease

2000 ◽  
Vol 162 (3) ◽  
pp. 826-831 ◽  
Author(s):  
GILLES DASSIEU ◽  
LAURENT BROCHARD ◽  
MOHAMED BENANI ◽  
SANDRINE AVENEL ◽  
CLAUDE DANAN
Keyword(s):  
Preterm Infants ◽  
Hyaline Membrane Disease ◽  
Tracheal Gas Insufflation ◽  
Hyaline Membrane

scholarly journals 176 LUNG MECHANICS AND GAS EXAWNCE DURING ARTIFICIAL SUPFACTANT (EXOSURE=E) ADMINISTRATION FOR HYALINE MEMBRANE DISEASE (HMD)

1991 ◽  
Vol 30 (6) ◽  
pp. 657-657
Author(s):  
Jürg Pfenninger ◽  
Denis Bachman ◽  
Emilio Bossi ◽  
Bendicht Wenger
Keyword(s):  
Hyaline Membrane Disease ◽  
Lung Mechanics ◽  
Hyaline Membrane

▾ Colfosceril palmitate (exosurf) – artificial surfactant for immature lungs

1991 ◽  
Vol 29 (12) ◽  
pp. 46.1-46
Keyword(s):  
Surface Tension ◽  
Respiratory Function ◽  
Distress Syndrome ◽  
Hyaline Membrane Disease ◽  
Lower Surface ◽  
Premature Babies ◽  
Hyaline Membrane ◽  
Lower Surface Tension ◽  
Reducing Substances ◽  
Artificial Surfactant

It has been known for about 30 years that lack of surface tension reducing substances (‘surfactant’) in the lungs of premature infants is largely responsible for the development of hyaline membrane disease or respiratory distress syndrome (RDS). About 50% of premature babies develop RDS, characteristically showing tachypnoea, chest retractions and worsening cyanosis. Many babies die of it or suffer complications. Mechanical ventilation is the main treatment, supporting respiratory function until maturing alveolar lining cells synthesise adequate surfactant. Despite its inherent risks it has proved very successful, but drugs which can lower surface tension in the lungs may improve outcome further.

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