scholarly journals Clinical Significance of Monitoring Circulating Free DNA and Plasma Heat Shock Protein 90alpha in Patients with Esophageal Squamous Cell Carcinoma

2021 ◽  
Vol Volume 13 ◽  
pp. 2223-2234
Author(s):  
Qiang Zhao ◽  
Congxiu Miao ◽  
Qingpu Lu ◽  
Weipeng Wu ◽  
Yuan He ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Heat Shock ◽  
Esophageal Squamous Cell Carcinoma ◽  
Heat Shock Protein ◽  
Cell Carcinoma ◽  
Clinical Significance ◽  
Squamous Cell ◽  
Circulating Free Dna ◽  
Free Dna

scholarly journals Clinical Significance of Monitoring Circulating Free DNA and Plasma Heat Shock Protein 90alpha in Patients with Esophageal Squamous Cell Carcinoma

2020 ◽  
Author(s):  
Qiang Zhao ◽  
Congxiu Miao ◽  
Qingpu Lu ◽  
Weipeng Wu ◽  
Yuan He ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Heat Shock ◽  
Esophageal Squamous Cell Carcinoma ◽  
Heat Shock Protein ◽  
Cell Carcinoma ◽  
Time Points ◽  
Circulating Free Dna ◽  
Post Surgery ◽  
Free Dna ◽  
Baseline Concentrations

Abstract Background: Esophageal squamous cell carcinoma (ESCC) is the predominant histological type of esophageal cancer in China and has an extremely poor prognosis. Circulating free DNA (cfDNA) and plasma heat shock protein 90alpha (Hsp90a) are two novel noninvasive biomarkers for diagnosis and prognostic prediction of several types of cancer. However, to the best of our knowledge, the roles of the two biomarkers in ESCC are still unknown.Methods: We recruited 93 primary ESCC patients and detected plasma concentrations of the two markers at different time points, including 1–3 days pre-chemotherapy, 1–7 days pre-surgery and 7–14 days post-surgery. Baseline concentrations of the two markers were associated with main characteristics of ESCC patients which were collected at first diagnosis. Correlation between the two markers and traditional serum biomarkers at baseline was also examined. Furthermore, dynamic changes of the cfDNA and Hsp90α concentrations among different time points and the potential clinical significance were assessed.Results: There was no significant association between baseline concentrations of the two markers and clinical features. Especially, cfDNA demonstrated stronger correlation with other circulating biomarkers than Hsp90α at baseline level. Importantly, both cfDNA and Hsp90α concentrations were significantly increased after surgery. Kaplan-Meier survival analysis showed that a change in concentration of cfDNA (ΔcfDNA) but not Hsp90α (ΔHSP90ɑ) between pre-surgery and post-surgery had significant effect on the overall survival of surgical patients with ESCC. Thus, ΔcfDNA evaluation could be a promising prognostic marker for surgical ESCC patients.Conclusions: Our findings may improve the understanding of the function of cfDNA and Hsp90α in ESCC.

scholarly journals Correlation between Clinicopathology and Expression of Heat Shock Protein 72 and Glycoprotein 96 in Human Esophageal Squamous Cell Carcinoma

2010 ◽  
Vol 2010 ◽  
pp. 1-8 ◽  
Author(s):  
Xiaoping Wang ◽  
Qiaoxia Wang ◽  
Huanping Lin
Keyword(s):  
Squamous Cell Carcinoma ◽  
Heat Shock ◽  
Esophageal Squamous Cell Carcinoma ◽  
Heat Shock Protein ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Squamous Cell Carcinomas ◽  
Heat Shock Protein 72 ◽  
Primary Tumors ◽  
Esophageal Squamous Cell Carcinomas

Heat shock protein 72 (HSP72) and glycoprotein 96 (gp96) are highly expressed in cancer tissues. Recent studies indicate the possible roles of HSP72 and gp96 in the development and progression of gastrointestinal carcinomas but detailed information is still ambiguous. We investigated the correlation between clinicopathology and expression of HSP72 and gp96 in human esophageal squamous cell carcinoma. The expression of HSP72 and gp96 was studied in 120 human esophageal squamous cell carcinomas with or without metastasis as well as in mucous membrane adjacent to cancers by way of immunohistochemistry. HSP72 immunoreactivities were detected in 112 of 120 primary tumors (93.3%) and in 30 of 120 mucous membranes adjacent to cancers (25.0%). Gp96 detected in esophageal squamous cell carcinoma and inmucous membrane adjacent to cancer was 85.0% and 20.0%, respectively. Both HSP72 and gp96 stained in cytoplasm. HSP72 and gp96 expression in esophageal squamous cell carcinomas withmetastasis was significantly higher than those with nonmetastasis (P<.05). The results indicate that there exists a significant correlation between the expression of HSP72 and gp96 and the progression of esophageal squamous cell carcinomas. HSP72 and gp96 expression were significantly associated with the presence of tumor infiltration, lymph node, and remote metastasis.

Expression of heat shock protein 70 in grossly resected esophageal squamous cell carcinoma

2002 ◽  
Vol 74 (1) ◽  
pp. 222-226 ◽  
Author(s):  
Tsuyoshi Noguchi ◽  
Shinsuke Takeno ◽  
Tomotaka Shibata ◽  
Yuzo Uchida ◽  
Shigeo Yokoyama ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Heat Shock ◽  
Esophageal Squamous Cell Carcinoma ◽  
Heat Shock Protein ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Heat Shock Protein 70

scholarly journals Expression of Heat Shock Protein-27 (Hsp27) and P38MAPK in Esophageal Squamous Cell Carcinoma

2017 ◽  
Vol 23 ◽  
pp. 5246-5253 ◽  
Author(s):  
Yan Zhang ◽  
Zhiyin Feng ◽  
Weina Wang ◽  
Juanjuan Dong ◽  
Xiaojin Gong ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Heat Shock ◽  
Esophageal Squamous Cell Carcinoma ◽  
Heat Shock Protein ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Heat Shock Protein 27

Proteomics-based identification of autoantibody against heat shock protein 70 as a diagnostic marker in esophageal squamous cell carcinoma

2008 ◽  
Vol 263 (2) ◽  
pp. 280-290 ◽  
Author(s):  
Yoshihisa Fujita ◽  
Toyofumi Nakanishi ◽  
Yoshiharu Miyamoto ◽  
Masako Hiramatsu ◽  
Hideaki Mabuchi ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Heat Shock ◽  
Esophageal Squamous Cell Carcinoma ◽  
Heat Shock Protein ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Heat Shock Protein 70 ◽  
Diagnostic Marker
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