Heat shock protein family B member 1 facilitates ezrin activation to control cell migration in esophageal squamous cell carcinoma

2019 ◽  
Vol 112 ◽  
pp. 79-87 ◽  
Author(s):  
Ying-Hua Xie ◽  
Li-Yan Li ◽  
Jian-Zhong He ◽  
Xiu-E Xu ◽  
Lian-Di Liao ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Migration ◽  
Heat Shock ◽  
Esophageal Squamous Cell Carcinoma ◽  
Heat Shock Protein ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Control Cell ◽  
Protein Family

scholarly journals Correlation between Clinicopathology and Expression of Heat Shock Protein 72 and Glycoprotein 96 in Human Esophageal Squamous Cell Carcinoma

2010 ◽  
Vol 2010 ◽  
pp. 1-8 ◽  
Author(s):  
Xiaoping Wang ◽  
Qiaoxia Wang ◽  
Huanping Lin
Keyword(s):  
Squamous Cell Carcinoma ◽  
Heat Shock ◽  
Esophageal Squamous Cell Carcinoma ◽  
Heat Shock Protein ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Squamous Cell Carcinomas ◽  
Heat Shock Protein 72 ◽  
Primary Tumors ◽  
Esophageal Squamous Cell Carcinomas

Heat shock protein 72 (HSP72) and glycoprotein 96 (gp96) are highly expressed in cancer tissues. Recent studies indicate the possible roles of HSP72 and gp96 in the development and progression of gastrointestinal carcinomas but detailed information is still ambiguous. We investigated the correlation between clinicopathology and expression of HSP72 and gp96 in human esophageal squamous cell carcinoma. The expression of HSP72 and gp96 was studied in 120 human esophageal squamous cell carcinomas with or without metastasis as well as in mucous membrane adjacent to cancers by way of immunohistochemistry. HSP72 immunoreactivities were detected in 112 of 120 primary tumors (93.3%) and in 30 of 120 mucous membranes adjacent to cancers (25.0%). Gp96 detected in esophageal squamous cell carcinoma and inmucous membrane adjacent to cancer was 85.0% and 20.0%, respectively. Both HSP72 and gp96 stained in cytoplasm. HSP72 and gp96 expression in esophageal squamous cell carcinomas withmetastasis was significantly higher than those with nonmetastasis (P<.05). The results indicate that there exists a significant correlation between the expression of HSP72 and gp96 and the progression of esophageal squamous cell carcinomas. HSP72 and gp96 expression were significantly associated with the presence of tumor infiltration, lymph node, and remote metastasis.

Expression of heat shock protein 70 in grossly resected esophageal squamous cell carcinoma

2002 ◽  
Vol 74 (1) ◽  
pp. 222-226 ◽  
Author(s):  
Tsuyoshi Noguchi ◽  
Shinsuke Takeno ◽  
Tomotaka Shibata ◽  
Yuzo Uchida ◽  
Shigeo Yokoyama ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Heat Shock ◽  
Esophageal Squamous Cell Carcinoma ◽  
Heat Shock Protein ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Heat Shock Protein 70

scholarly journals Expression of Heat Shock Protein-27 (Hsp27) and P38MAPK in Esophageal Squamous Cell Carcinoma

2017 ◽  
Vol 23 ◽  
pp. 5246-5253 ◽  
Author(s):  
Yan Zhang ◽  
Zhiyin Feng ◽  
Weina Wang ◽  
Juanjuan Dong ◽  
Xiaojin Gong ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Heat Shock ◽  
Esophageal Squamous Cell Carcinoma ◽  
Heat Shock Protein ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Heat Shock Protein 27

Proteomics-based identification of autoantibody against heat shock protein 70 as a diagnostic marker in esophageal squamous cell carcinoma

2008 ◽  
Vol 263 (2) ◽  
pp. 280-290 ◽  
Author(s):  
Yoshihisa Fujita ◽  
Toyofumi Nakanishi ◽  
Yoshiharu Miyamoto ◽  
Masako Hiramatsu ◽  
Hideaki Mabuchi ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Heat Shock ◽  
Esophageal Squamous Cell Carcinoma ◽  
Heat Shock Protein ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Heat Shock Protein 70 ◽  
Diagnostic Marker
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