scholarly journals Clinicopathological characteristics and recurrence risk of papillary thyroid microcarcinoma in the elderly

2019 ◽  
Vol Volume 11 ◽  
pp. 2371-2377 ◽  
Author(s):  
Xiaofei Wang ◽  
Jianyong Lei ◽  
Tao Wei ◽  
Jingqiang Zhu ◽  
Zhihui Li
Keyword(s):  
The Elderly ◽  
Recurrence Risk ◽  
Clinicopathological Characteristics ◽  
Papillary Thyroid Microcarcinoma ◽  
Papillary Thyroid ◽  
Thyroid Microcarcinoma

scholarly journals Clinical-pathological Characteristics and Prognostic Factors for Papillary Thyroid Microcarcinoma in the Elderly

2018 ◽  
Vol 9 (2) ◽  
pp. 256-262 ◽  
Author(s):  
Jing Tang ◽  
Hans B. Liu ◽  
Lujiao Yu ◽  
Xin Meng ◽  
Sean X. Leng ◽  
...  
Keyword(s):  
Prognostic Factors ◽  
The Elderly ◽  
Papillary Thyroid Microcarcinoma ◽  
Papillary Thyroid ◽  
Pathological Characteristics ◽  
Thyroid Microcarcinoma

Observation versus thyroidectomy for papillary thyroid microcarcinoma in the elderly

2016 ◽  
Vol 131 (2) ◽  
pp. 173-176 ◽  
Author(s):  
U C Megwalu
Keyword(s):  
Elderly Patients ◽  
Propensity Score Analysis ◽  
The Elderly ◽  
Hazard Ratio ◽  
Surgical Patients ◽  
Papillary Thyroid Microcarcinoma ◽  
Study Cohort ◽  
Papillary Thyroid ◽  
Thyroid Microcarcinoma ◽  
Score Analysis

AbstractObjective:To compare the effectiveness of non-surgical versus surgical therapy in elderly patients with papillary thyroid microcarcinoma.Methods:The study cohort included 2323 elderly patients (aged 65 years and over) diagnosed with papillary thyroid microcarcinoma between 1988 and 2009, identified in the Surveillance, Epidemiology, and End Results 18 database of the National Cancer Institute.Results:The five-year overall survival rate was 23 per cent for non-surgical patients compared with 91 per cent for surgical patients (p < 0.0001). Unadjusted analysis revealed significantly improved survival in surgical patients compared with non-surgical patients (hazard ratio = 0.06; p < 0.0001). Propensity score analysis also revealed significantly improved survival in surgical patients compared with non-surgical patients (hazard ratio = 0.11; p < 0.0001).Conclusion:Thyroidectomy appears to provide a survival benefit for elderly patients with papillary thyroid microcarcinoma. High-quality prospective studies are needed to better evaluate the comparative effectiveness of immediate thyroidectomy versus observation for elderly patients with papillary thyroid microcarcinoma.

scholarly journals Clinicopathological Characteristics of Incidental Papillary Thyroid Microcarcinoma in an Endemic Goiter Area

2020 ◽  
Vol 10 (16) ◽  
pp. 5532
Author(s):  
Radu Danila ◽  
Roxana Maria Livadariu ◽  
Daniel Vasile Timofte ◽  
Irina Trifescu ◽  
Tudor Bibire ◽  
...  
Keyword(s):  
Endocrine System ◽  
Hashimoto Thyroiditis ◽  
Clinicopathological Characteristics ◽  
University Hospital ◽  
Papillary Thyroid Microcarcinoma ◽  
Papillary Thyroid ◽  
Thyroid Microcarcinoma ◽  
Basedow’S Disease ◽  
Aggressive Surgical Approach ◽  
Underlying Diseases

Papillary thyroid microcarcinoma (PTMC) is a common malignant disease of the endocrine system, which has rapidly increased in incidence and prevalence in recent decades. The aim of our paper was to identify correlations between pathological and clinical features of cases of PTMC. A total of 612 patients of both genders, who were operated on for benign thyroid diseases in the 3rd Surgical Unit of St. Spiridon University Hospital of Iasi, were monitored for a period of 2 years. According to pathological reports, PTMC was diagnosed in 144 cases. Of those cases, 81.2% were female and 18.8% were male, with an overall mean age of 54.77 ± 11.9 years. The mean diameter of tumors was 3.04 ± 2.2 mm (75.7% were under 5 mm), and 35.4% were multifocal tumors. Of all tumors studied, 76.4% were the follicular variant, 13.2% were conventional, and 10.4% of cases included tall cell, hobnail, or columnar variants. The underlying diseases were multinodular goiters (73.6%), adenomas (25%), Hashimoto thyroiditis (17.4%), Basedow’s disease, and other types of hyperthyroidism (4.9%), primarily hyperparathyroidism (7.6%), with a small percentage presenting a combination thereof. Extracapsular invasion was present in 14.6% while 5.6% presented perineural invasion and 0.7% of cases had vascular invasion. Lymphatic emboli were found in 9% of cases and lymph node metastasis in 5.6% of cases. PTMC is not as innocent as believed, and further studies, performed on larger batches, would be necessary in order to identify high oncological risk cases and to determine when a more aggressive surgical approach is indicated.

Papillary thyroid microcarcinoma: clinicopathological characteristics and implications for treatment in 276 patients

2011 ◽  
Vol 42 (6) ◽  
pp. 657-664 ◽  
Author(s):  
Ioannis Vasileiadis ◽  
Efthimios Karakostas ◽  
Georgios Charitoudis ◽  
Anna Stavrianaki ◽  
Stylianos Kapetanakis ◽  
...  
Keyword(s):  
Clinicopathological Characteristics ◽  
Papillary Thyroid Microcarcinoma ◽  
Papillary Thyroid ◽  
Thyroid Microcarcinoma

The BRAF Mutation Is Predictive of Aggressive Clinicopathological Characteristics in Papillary Thyroid Microcarcinoma

2010 ◽  
Vol 17 (12) ◽  
pp. 3294-3300 ◽  
Author(s):  
Kuai-Lu Lin ◽  
Ou-Chen Wang ◽  
Xiao-Hua Zhang ◽  
Xuan-Xuan Dai ◽  
Xiao-Qu Hu ◽  
...  
Keyword(s):  
Braf Mutation ◽  
Clinicopathological Characteristics ◽  
Papillary Thyroid Microcarcinoma ◽  
Papillary Thyroid ◽  
Thyroid Microcarcinoma

scholarly journals BRAFV600E mutation in papillary thyroid microcarcinoma: a meta-analysis

2015 ◽  
Vol 22 (2) ◽  
pp. 159-168 ◽  
Author(s):  
Fei Li ◽  
Guangqi Chen ◽  
Chunjun Sheng ◽  
Aaron M Gusdon ◽  
Yueye Huang ◽  
...  
Keyword(s):  
Meta Analysis ◽  
Clinicopathological Characteristics ◽  
Clinicopathological Features ◽  
Papillary Thyroid Microcarcinoma ◽  
Cochrane Library ◽  
Papillary Thyroid ◽  
Brafv600e Mutation ◽  
Thyroid Microcarcinoma ◽  
Significant Difference ◽  
The Cochrane Library

The prognostic value of the BRAFV600E mutation, resulting in poor clinical outcomes of papillary thyroid carcinoma, has been generally confirmed. However, the association of BRAFV600E with aggressive clinical behaviors of papillary thyroid microcarcinoma (PTMC) has not been firmly established in individual studies. We performed this meta-analysis to examine the relationship between BRAFV600E mutation and the clinicopathological features of PTMC. We conducted a systematic search in PubMed, EMBASE, and the Cochrane library for relevant studies. We selected all the studies that reported clinicopathological features of PTMC patients with information available on BRAFV600E mutation status. Nineteen studies involving a total of 3437 patients met these selection criteria and were included in the analyses. The average prevalence of the BRAFV600E mutation was 47.48%, with no significant difference with respect to patient sex (male versus female) and age (younger than 45 years versus 45 years or older). Compared with the WT BRAF gene, the BRAFV600E mutation was associated with tumor multifocality (odds ratio (OR) 1.38; 95% CI, 1.04–1.82), extrathyroidal extension (OR 3.09; 95% CI, 2.24–4.26), lymph node metastases (OR 2.43; 95% CI, 1.28–4.60), and advanced stage (OR 2.39; 95% CI, 1.38–4.15) of PTMC. Thus, our findings from this large meta-analysis definitively demonstrate that BRAFV600E-mutation-positive PTMC are more likely to manifest with aggressive clinicopathological characteristics. In appropriate clinical settings, testing for the BRAFV600E mutation is likely to be useful in assisting the risk stratification and management of PTMC.

Clinical Characteristics of Papillary Thyroid Microcarcinoma

2010 ◽  
Vol 53 (3) ◽  
pp. 166 ◽  
Author(s):  
Jae Won Kim ◽  
Dong Youl Lee ◽  
Young Up Cho ◽  
Chang Hyo Kim ◽  
Yoon Suk Oh ◽  
...  
Keyword(s):  
Clinical Characteristics ◽  
Papillary Thyroid Microcarcinoma ◽  
Papillary Thyroid ◽  
Thyroid Microcarcinoma
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