scholarly journals Clinicopathological Characteristics of Incidental Papillary Thyroid Microcarcinoma in an Endemic Goiter Area

2020 ◽  
Vol 10 (16) ◽  
pp. 5532
Author(s):  
Radu Danila ◽  
Roxana Maria Livadariu ◽  
Daniel Vasile Timofte ◽  
Irina Trifescu ◽  
Tudor Bibire ◽  
...  
Keyword(s):  
Endocrine System ◽  
Hashimoto Thyroiditis ◽  
Clinicopathological Characteristics ◽  
University Hospital ◽  
Papillary Thyroid Microcarcinoma ◽  
Papillary Thyroid ◽  
Thyroid Microcarcinoma ◽  
Basedow’S Disease ◽  
Aggressive Surgical Approach ◽  
Underlying Diseases

Papillary thyroid microcarcinoma (PTMC) is a common malignant disease of the endocrine system, which has rapidly increased in incidence and prevalence in recent decades. The aim of our paper was to identify correlations between pathological and clinical features of cases of PTMC. A total of 612 patients of both genders, who were operated on for benign thyroid diseases in the 3rd Surgical Unit of St. Spiridon University Hospital of Iasi, were monitored for a period of 2 years. According to pathological reports, PTMC was diagnosed in 144 cases. Of those cases, 81.2% were female and 18.8% were male, with an overall mean age of 54.77 ± 11.9 years. The mean diameter of tumors was 3.04 ± 2.2 mm (75.7% were under 5 mm), and 35.4% were multifocal tumors. Of all tumors studied, 76.4% were the follicular variant, 13.2% were conventional, and 10.4% of cases included tall cell, hobnail, or columnar variants. The underlying diseases were multinodular goiters (73.6%), adenomas (25%), Hashimoto thyroiditis (17.4%), Basedow’s disease, and other types of hyperthyroidism (4.9%), primarily hyperparathyroidism (7.6%), with a small percentage presenting a combination thereof. Extracapsular invasion was present in 14.6% while 5.6% presented perineural invasion and 0.7% of cases had vascular invasion. Lymphatic emboli were found in 9% of cases and lymph node metastasis in 5.6% of cases. PTMC is not as innocent as believed, and further studies, performed on larger batches, would be necessary in order to identify high oncological risk cases and to determine when a more aggressive surgical approach is indicated.

scholarly journals MON-449 Thyroid Microcarcinoma Histopathology Relevance

2020 ◽  
Vol 4 (Supplement_1) ◽  
Author(s):  
Letícia A M Sandoval ◽  
Bruna Dellatorre Diniz ◽  
Juliano Coelho ◽  
Gabriel de Jesus ◽  
Monalisa F Azevedo ◽  
...  
Keyword(s):  
Clinical Diagnosis ◽  
Needle Aspiration ◽  
University Hospital ◽  
Papillary Thyroid Microcarcinoma ◽  
Histological Evaluation ◽  
Papillary Thyroid ◽  
False Negatives ◽  
Surgical Specimen ◽  
Thyroid Microcarcinoma ◽  
New Diagnosis

Abstract INTRODUCTION: Thyroid carcinoma is the most common endocrine neoplasia. The predominant histological variant is the papillary subtype. Tumors with 1 centimeter diameter or less are defined as papillary thyroid microcarcinoma (PTMC). The clinical diagnosis of PTMC is challenging. The evaluation of the gland includes mostly image methods and fine-needle aspiration (FNA). Nevertheless, the sensibility of these techniques, when compared to total thyroid histology, is less than desired. AIM OF THE STUDY: Recognize the real prevalence of papillary thyroid microcarcinoma (PTMC) based on histological evaluation of the total gland among a group of adults in Brasilia, Brazil, and compare the data with the clinical suspicion of PTMC established by FNA and ultrasonography (USG). PATIENTS AND METHODS: Retrospective cohort study based on medical records of 76 patients who underwent surgical thyroidectomy treatment for several types of thyroid diseases at the University Hospital of Brasilia - Brazil, from 2005 to 2015. A full inclusion of the surgical specimen was made and stained with hematoxylin and eosin. All of the preparations were evaluated by an expert pathologist. The histopathological report was compared to the previous clinical diagnosis, which was based on FNA and USG of the gland. In addition, the exams results were stratified by the Bethesda criteria. RESULTS: Seventy-six individuals with the histopathology diagnosis of PTMC were included (68 were females). A total of 65 FNA and 57 USG results were evaluated, 6 patients had only the histopathologic diagnosis of PTMC. A total of 52 patients had both USG and FNA of the thyroid. All of the patients that had USG records had at least one thyroid nodule, 52,6% of them had multiple nodules. Regarding the FNA results, only 9,2% were classified as Bethesda I; 21,5% as Bethesda II; 7,7% Bethesda III; 7,7% Bethesda IV; 10,8% Bethesda V; 43,1% Bethesda VI. At this cohort, 19 patients were false negatives. The sensibility of FNA for diagnosis of PTMC was 67,79%. CONCLUSION: Despite careful evaluation of the patients, there might have false negatives results. Total thyroid total inclusion of surgical specimen is not a routine diagnostic tool, making less invasive new diagnosis methods desirable.

scholarly journals Factors Influencing the Outcome of Patients with Incidental Papillary Thyroid Microcarcinoma

2012 ◽  
Vol 2012 ◽  
pp. 1-5 ◽  
Author(s):  
Beatriz Mantinan ◽  
Antonia Rego-Iraeta ◽  
Alejandra Larrañaga ◽  
Enrique Fluiters ◽  
Paula Sánchez-Sobrino ◽  
...  
Keyword(s):  
Recurrence Rate ◽  
Tumour Size ◽  
Univariate Analysis ◽  
Significant Risk ◽  
Distant Metastases ◽  
Significant Risk Factor ◽  
University Hospital ◽  
Papillary Thyroid Microcarcinoma ◽  
Papillary Thyroid ◽  
Thyroid Microcarcinoma

Objective. To analyze some factors that could influence the outcome of patients with PTMC.Material and Methods. This is a longitudinal observational study. All patients diagnosed and treated for papillary thyroid microcarcinoma at the University Hospital of Vigo, between January 1994 and December 2003, were included in the present study. Demographic characteristics, tumour characteristics, TNM stage, rate of recurrence, and treatment with131I were the study variables.Results. Ninety-one patients (75 females) with an average age of years, range 19–81, were studied. Initial tumour staging was T1 in 90 patients and T4a in 1 case. Initial lymph node involvement was present in 4 cases (4.4%). We only found one case with distant metastases at diagnosis. Postsurgical evaluation of thyroid specimens revealed that 28 (30.7%) tumours were multifocal. The average size of the tumour was  cm, range 0.1–1. Univariate analysis reveals a statistically significant association between tumour multifocality and postsurgical131I therapy with the recurrence rate. In the multivariate analysis only multifocality (, HR 5.7) was a significant risk factor for the recurrence rate.Conclusions. Our results indicate that tumour multifocality is an independent predictor of relapse but neither the tumour size nor postsurgical131I therapy.

Papillary thyroid microcarcinoma: clinicopathological characteristics and implications for treatment in 276 patients

2011 ◽  
Vol 42 (6) ◽  
pp. 657-664 ◽  
Author(s):  
Ioannis Vasileiadis ◽  
Efthimios Karakostas ◽  
Georgios Charitoudis ◽  
Anna Stavrianaki ◽  
Stylianos Kapetanakis ◽  
...  
Keyword(s):  
Clinicopathological Characteristics ◽  
Papillary Thyroid Microcarcinoma ◽  
Papillary Thyroid ◽  
Thyroid Microcarcinoma

The BRAF Mutation Is Predictive of Aggressive Clinicopathological Characteristics in Papillary Thyroid Microcarcinoma

2010 ◽  
Vol 17 (12) ◽  
pp. 3294-3300 ◽  
Author(s):  
Kuai-Lu Lin ◽  
Ou-Chen Wang ◽  
Xiao-Hua Zhang ◽  
Xuan-Xuan Dai ◽  
Xiao-Qu Hu ◽  
...  
Keyword(s):  
Braf Mutation ◽  
Clinicopathological Characteristics ◽  
Papillary Thyroid Microcarcinoma ◽  
Papillary Thyroid ◽  
Thyroid Microcarcinoma

scholarly journals BRAFV600E mutation in papillary thyroid microcarcinoma: a meta-analysis

2015 ◽  
Vol 22 (2) ◽  
pp. 159-168 ◽  
Author(s):  
Fei Li ◽  
Guangqi Chen ◽  
Chunjun Sheng ◽  
Aaron M Gusdon ◽  
Yueye Huang ◽  
...  
Keyword(s):  
Meta Analysis ◽  
Clinicopathological Characteristics ◽  
Clinicopathological Features ◽  
Papillary Thyroid Microcarcinoma ◽  
Cochrane Library ◽  
Papillary Thyroid ◽  
Brafv600e Mutation ◽  
Thyroid Microcarcinoma ◽  
Significant Difference ◽  
The Cochrane Library

The prognostic value of the BRAFV600E mutation, resulting in poor clinical outcomes of papillary thyroid carcinoma, has been generally confirmed. However, the association of BRAFV600E with aggressive clinical behaviors of papillary thyroid microcarcinoma (PTMC) has not been firmly established in individual studies. We performed this meta-analysis to examine the relationship between BRAFV600E mutation and the clinicopathological features of PTMC. We conducted a systematic search in PubMed, EMBASE, and the Cochrane library for relevant studies. We selected all the studies that reported clinicopathological features of PTMC patients with information available on BRAFV600E mutation status. Nineteen studies involving a total of 3437 patients met these selection criteria and were included in the analyses. The average prevalence of the BRAFV600E mutation was 47.48%, with no significant difference with respect to patient sex (male versus female) and age (younger than 45 years versus 45 years or older). Compared with the WT BRAF gene, the BRAFV600E mutation was associated with tumor multifocality (odds ratio (OR) 1.38; 95% CI, 1.04–1.82), extrathyroidal extension (OR 3.09; 95% CI, 2.24–4.26), lymph node metastases (OR 2.43; 95% CI, 1.28–4.60), and advanced stage (OR 2.39; 95% CI, 1.38–4.15) of PTMC. Thus, our findings from this large meta-analysis definitively demonstrate that BRAFV600E-mutation-positive PTMC are more likely to manifest with aggressive clinicopathological characteristics. In appropriate clinical settings, testing for the BRAFV600E mutation is likely to be useful in assisting the risk stratification and management of PTMC.

Clinical Characteristics of Papillary Thyroid Microcarcinoma

2010 ◽  
Vol 53 (3) ◽  
pp. 166 ◽  
Author(s):  
Jae Won Kim ◽  
Dong Youl Lee ◽  
Young Up Cho ◽  
Chang Hyo Kim ◽  
Yoon Suk Oh ◽  
...  
Keyword(s):  
Clinical Characteristics ◽  
Papillary Thyroid Microcarcinoma ◽  
Papillary Thyroid ◽  
Thyroid Microcarcinoma
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