scholarly journals Demographic shift disproportionately increases cancer burden in an aging nation: current and expected incidence and mortality in Hungary up to 2030

2018 ◽  
Vol Volume 10 ◽  
pp. 1093-1108 ◽  
Author(s):  
Otilia Menyhárt ◽  
János Fekete ◽  
Balázs Győrffy
Keyword(s):  
Demographic Shift ◽  
Cancer Burden ◽  
Incidence And Mortality

scholarly journals Discrepancies between Canadian cancer research funding and site-specific cancer burden: a spotlight on ten disease sites

2018 ◽  
Vol 25 (5) ◽  
Author(s):  
A. C. Coronado ◽  
C. Finley ◽  
K. Badovinac ◽  
J. Han ◽  
J. Niu ◽  
...  
Keyword(s):  
Cancer Research ◽  
Research Funding ◽  
Information Management System ◽  
Site Specific ◽  
Cancer Burden ◽  
Specific Research ◽  
Research Survey ◽  
Research Investment ◽  
Incidence And Mortality ◽  
Specific Cancer

BackgroundCancer research is essential in evaluating the safety and effectiveness of emerging cancer treatments, which in turn can lead to ground-breaking advancements in cancer care. Given limited research funding, allocating resources in alignment with societal burden is essential. However, evidence shows that such alignment does not typically occur. The objective of the present study was to provide an updated overview of site-specific cancer research investment in Canada and to explore potential discrepancies between the site-specific burden and the level of research investment.MethodsThe 10 cancer sites with the highest mortality in 2015—which included brain, female breast, colorectal, leukemia, lung, non-Hodgkin lymphoma, ovary, pancreas, prostate, and uterus—were selected for the analysis. Information about site-specific research investment and cancer burden (raw incidence and mortality) was obtained from the Canadian Cancer Research Survey and Statistics Canada’s cansim (the Canadian Socio-Economic Information Management System) respectively. The ratio of site-specific research investment to site-specific burden was used as an indicator of overfunding (ratio > 1) or underfunding (ratio < 1).ResultsThe 3 cancer sites with the highest research investments were leukemia, prostate, and breast, which together represented 51.3% of 2015 cancer research funding. Conversely, the 3 cancer sites with the lowest investments were uterus, pancreas, and ovary, which together represented 7.8% of 2015 research funding. Relative to site-specific cancer burden, the lung, uterus, and colorectal sites were consistently the most underfunded.ConclusionsObserved discrepancies between cancer burden and research investment indicate that some cancer sites (such as lung, colorectal, and uterus) seem to be underfunded when site-specific incidence and mortality are taken into consideration.

scholarly journals The European cancer burden in 2020: Incidence and mortality estimates for 40 countries and 25 major cancers

2021 ◽  
Vol 157 ◽  
pp. 308-347
Author(s):  
Tadeusz Dyba ◽  
Giorgia Randi ◽  
Freddie Bray ◽  
Carmen Martos ◽  
Francesco Giusti ◽  
...  
Keyword(s):  
Cancer Burden ◽  
Incidence And Mortality ◽  
Mortality Estimates ◽  
European Cancer

scholarly journals Analysis of the National Cancer Institute’s Investment in Site-Specific Cancer Research Funding Involving Collaborators in Latin America and Its Correspondence to Regional Cancer Burden

2020 ◽  
Vol 6 (Supplement_1) ◽  
pp. 21-21
Author(s):  
Jasmin Serena Vargas ◽  
Rachel Abudu ◽  
Kalina Duncan
Keyword(s):  
Cancer Research ◽  
Latin America ◽  
Cancer Incidence ◽  
National Cancer Institute ◽  
Research Funding ◽  
Tumor Site ◽  
Site Specific ◽  
Cancer Burden ◽  
Incidence And Mortality ◽  
Uterine Cancers

PURPOSE Economic and social-behavioral changes over the last two decades in Latin America and the Caribbean (LAC) are associated with increases in the regional cancer burden. We aim to describe the National Cancer Institute–funded extramural research portfolio with collaborators in the LAC between fiscal years 2014 and 2018 and compare project numbers by site with subregional cancer burden. METHODS This analysis included National Cancer Institute–funded extramural projects with LAC collaborators from fiscal years 2014 to 2018 from the National Institutes of Health IMPAC II database. Projects were stratified by Pan American Health Organization’s Latin American subregions, tumor sites, and regional site-specific rates of cancer incidence and mortality using Globocan 2018 estimates. To better understand subregional variations in cancer incidence and mortality, this analysis focused on the top 5 sites of incidence and mortality in LAC after breast and prostate cancer. RESULTS Between fiscal years 2014 and 2018, 108 projects with LAC collaborators were funded. Project collaborators came from 22 countries in the region, and projects covered 20 tumor sites. The Southern Cone had the most projects funded, followed by the Central American Isthmus and Mexico, Andes, Latin Caribbean, and non-Latin Caribbean—this was roughly proportional to subregional populations. Variation exists at the subregional level for the top 5 cancers when comparing incidence and mortality with subregional project counts. Disparities between projects and incidence by tumor site were the largest for colorectal, lung, and uterine cancers. Disparities between projects and mortality by tumor site were the largest for lung and uterine cancers. Disparities between projects and both components of cancer burden by subregion were the largest for the Latin Caribbean and non-Latin Caribbean. The number of funded projects for Kaposi sarcoma and non-Hodgkin lymphoma largely outpaced both incidence and mortality in every subregion. CONCLUSION This analysis suggests that projects’ alignment with cancer burden is variable by subregion, provides an understanding of cancer research funding by site, and highlights areas of interest for additional investigation, training, and collaboration in LAC.

scholarly journals Influence of Age on 2040 Cancer Burden in the Older Population of the Gulf Cooperation Council (GCC) Countries: Public Health Implications

2021 ◽  
Vol 28 ◽  
pp. 107327482110271
Author(s):  
Sohaila Cheema ◽  
Patrick Maisonneuve ◽  
Albert B. Lowenfels ◽  
Amit Abraham ◽  
Sathyanarayanan Doraiswamy ◽  
...  
Keyword(s):  
Public Health ◽  
Eastern Mediterranean Region ◽  
Gulf Cooperation Council ◽  
World Health ◽  
International Agency ◽  
Older Population ◽  
Cancer Burden ◽  
Health Implications ◽  
Gcc Countries ◽  
Incidence And Mortality

Introduction and Study Aims: The underlying population of global regions varies widely and is a major determinant of regional cancer differences. The aims were to: (1) estimate the cancer burden in Gulf Cooperation Council (GCC) countries in 2040 for the ≥70 population and (2) assess the public health implications for this cancer increase. Methods: We used Global Cancer Observatory (GLOBOCAN) estimates of cancer incidence and mortality for people aged 70 years or more in GCC countries from 2018 to 2040 from the International Agency for Research on Cancer. For population growth, we used data for the same period from the Population Division of the United Nations Department of Economic and Social Affairs. From these, we calculated the predicted increase in the number of cancer cases and cancer deaths from 2018 to 2040 and the proportion of cases/deaths represented by those aged 70+ for the 2 time periods. Findings: In the GCC countries, the predicted number of newly diagnosed cancers and cancer deaths in the older population will increase by 465% and 462% respectively due to demographic changes—greater than other countries in the World Health Organization Eastern Mediterranean Region, or in countries of similar economic development. The largest predicted increases will be for Qatar and the United Arab Emirates. Based on the predicted population age, cancer burden among older people in the GCC countries will increase by approximately 460%. Conclusion: By the year 2040, the relationship between cancer and age will cause a 4- to 5-fold increase in the cancer burden in the GCC. These predictable changes will require additional planning and resources to provide appropriate healthcare.

Predictive global trends in the incidence and mortality of pancreatic cancer based on geographic location, socio-economic status, and demographic shift

2016 ◽  
Vol 114 (6) ◽  
pp. 736-742 ◽  
Author(s):  
Chandrakanth Are ◽  
Sanjib Chowdhury ◽  
Humera Ahmad ◽  
Advaitaa Ravipati ◽  
Tianqiang Song ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Economic Status ◽  
Geographic Location ◽  
Demographic Shift ◽  
Global Trends ◽  
Socio Economic Status ◽  
Incidence And Mortality

scholarly journals Breast Cancer burden in Tunisia: situation in 2017 and projections by 2030

2019 ◽  
Vol 29 (Supplement_4) ◽  
Author(s):  
A Cherif ◽  
S Dhaouadi ◽  
M Osman ◽  
M Hsairi
Keyword(s):  
Breast Cancer ◽  
Screening Program ◽  
Demographic Data ◽  
Breast Cancer Incidence ◽  
Premature Mortality ◽  
Epidemiological Data ◽  
Cancer Burden ◽  
Effective Interventions ◽  
Life Years ◽  
Incidence And Mortality

Abstract Introduction Despite advances in diagnostic and treatment of cancer, burden of this disease is increasing worldwide. Breast Cancer is one of the leading cancers and major causes of death among female worldwide. The aim of this study was to describe the breast cancer burden in Tunisia in terms of disability adjusted life years (DALY) in 2017 and to perform projections by 2030. Methods DALYs for cancer are the sum of years of potential life lost due to premature mortality (Years Life Lost (YLL) and the years lived with disability (YLD). We used epidemiological data (incidence rate, death rate, DALY, YLL and YLD) estimated by the Institute for Health Metrics and Evaluation (IHME). Demographic data were provided by the National institute of statistics. The projection of DALYs for breast cancer through 2030 was performed by a Poisson Regression analysis with Age -Period -Cohort (APC) using SPSS software while using IHME estimated data for the period 1990-2017. Results In 2017, breast cancer incidence and mortality rate among females in Tunisia were 50.17/100000 persons years and 14.04/100000 persons years respectively. Breast cancer DALY values were 25145 (438 /100000 persons years). The percentage of YLL in DALYS was 92.4%. Without effective interventions, the number of DALYs due to breast cancer would reach 40071 in 2030 with a standardized rate of 507/100000 persons years (IC 95% = [501/100000 to 514/100000]. The number of YLL predicted will attain 36457 with a standardized rate of 461/100000 persons years. Conclusions The burden of breast cancer among Tunisian women in 2017 is relatively high mainly due to the lack of screening program. There is an urgent need of a strong plan of early detection and appropriate care. Key messages Burden of breast cancer among women in 2017 is high and will rise in 2030. Renforcing screening program is urgent.

Breast cancer burden in Africa: evidence from GLOBOCAN 2018

2020 ◽  
Author(s):  
Rajesh Sharma
Keyword(s):  
Breast Cancer ◽  
Central African Republic ◽  
The Gambia ◽  
Limited Resources ◽  
African Countries ◽  
Cancer Burden ◽  
Stage Disease ◽  
Incidence And Mortality ◽  
Standardized Mortality Rate ◽  
Mortality Estimates

Abstract Background Breast cancer is the leading malignancy in African females. This study aims to examine the breast cancer burden in Africa using recently released GLOBOCAN 2018 estimates. Methods The incidence and mortality estimates of age- and country-wise burden of breast cancer in 54 African countries were obtained from GLOBOCAN 2018. Results In Africa, breast cancer caused 74 072 deaths, and 168 690 cases were estimated to have occurred in 2018. The age-standardized incidence rate stood at 37.9/100 000 in Africa, varying from 6.9/100 000 in the Gambia to 69.6/100 000 in Mauritius. The age-standardized mortality rate stood at 17.2/100 000 in 2018, ranging from 4/100 000 in the Gambia to 29.1/100 000 in Somalia in 2018. Nigeria was the leading country in terms of absolute burden with 26 310 cases and 11 564 deaths, followed by Egypt with 23 081 new cases and 9254 deaths. The mortality-to-incidence ratio for Africa stood at 0.44, varying from 0.24 in Libya to 0.68 in the Central African Republic. Conclusion To tackle breast cancer burden in Africa, the main challenges are late-stage disease presentation, lack of screening and therapeutic infrastructure, lack of awareness and limited resources.

scholarly journals The Burden and Trends of Primary Liver Cancer Caused by Specific Etiologies from 1990 to 2017 at the Global, Regional, National, Age, and Sex Level Results from the Global Burden of Disease Study 2017

Liver Cancer ◽  
2020 ◽  
Vol 9 (5) ◽  
pp. 563-582 ◽  
Author(s):  
Longfei Lin ◽  
Lei Yan ◽  
Yuling Liu ◽  
Changhai Qu ◽  
Jian Ni ◽  
...  
Keyword(s):  
Liver Cancer ◽  
Cancer Incidence ◽  
Burden Of Disease ◽  
Primary Liver Cancer ◽  
Global Burden Of Disease ◽  
Global Burden ◽  
Targeted Prevention ◽  
Cancer Burden ◽  
Incidence And Mortality ◽  
Disease Study

Background: Liver cancer is one of the leading causes of cancer-related deaths worldwide. The primary causes of liver cancer include hepatitis B virus (HBV), hepatitis C virus (HCV), alcohol consumption, nonalcoholic fatty liver disease, and other factors. Aims: The objective of this study was to evaluate the global and sex-, age-, region-, country-, and etiology-related liver cancer burden, as well as the trends in liver cancer caused by different etiologies. Methods: The causes of liver cancer from 1990 to 2017, including global, regional, and national liver cancer incidence, mortality, and etiology, were collected from the Global Burden of Disease study 2017, and the time-dependent change in the trends of liver cancer burden was evaluated by annual percentage change. Results: The global liver cancer incidence and mortality have been increasing. There were 950,000 newly-diagnosed liver cancer cases and over 800,000 deaths in 2017, which is more than twice the numbers recorded in 1990. HBV and HCV are the major causes of liver cancer. HBV is the major risk factor of liver cancer in Asia, while HCV and alcohol abuse are the major risk factors in the high sociodemographic index and high human development index regions. The mean onset age and incidence of liver cancer with different etiologies have gradually increased in the past 30 years. Conclusions: The global incidence is still rising and the causes have national, regional, or population specificities. More targeted prevention strategies must be developed for the different etiologic types in order to reduce liver cancer burden.

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