The Role of Antimotility and Antisecretory Agents in the Management of Short Bowel Syndrome

2016 ◽  
pp. 217-226 ◽  
Author(s):  
Mandy Corrigan ◽  
Donald Kirby
Keyword(s):  
Short Bowel Syndrome ◽  
Short Bowel

Short bowel syndrome: the role of GLP-2 on improving outcome

2009 ◽  
Vol 12 (5) ◽  
pp. 526-532 ◽  
Author(s):  
Katharina Wallis ◽  
Julian RF Walters ◽  
Simon Gabe
Keyword(s):  
Short Bowel Syndrome ◽  
Short Bowel

scholarly journals Distraction-Induced Intestinal Growth: The Role of Mechanotransduction Mechanisms in a Mouse Model of Short Bowel Syndrome

2013 ◽  
pp. 131106060201007 ◽  
Author(s):  
Ryo Sueyoshi ◽  
Kathleen M. Woods Ignatoski ◽  
Manabu Okawada ◽  
Daniel H. Teitelbaum
Keyword(s):  
Mouse Model ◽  
Short Bowel Syndrome ◽  
Intestinal Growth ◽  
Short Bowel

scholarly journals Surgical management of intestinal failure

2003 ◽  
Vol 62 (3) ◽  
pp. 711-718 ◽  
Author(s):  
G. L. Carlson
Keyword(s):  
Surgical Treatment ◽  
Short Bowel Syndrome ◽  
Surgical Management ◽  
Nutritional Support ◽  
Intestinal Failure ◽  
Short Bowel ◽  
Abdominal Infection ◽  
Intra Abdominal Infection ◽  
Acute Intestinal Failure

Surgery plays a key role in the management of both acute and, less frequently, chronic intestinal failure. Acute intestinal failure frequently requires surgical treatment when it arises as a consequence of intestinal fistulation or obstruction. In specialised clinical practice approximately 50% of acute intestinal failure is associated with intestinal fistulas and in approximately 50% of patients, this condition arises as part of the natural history or complicating treatment for Crohn's disease. A considerable proportion of such patients have abdominal infection and present complex nutritional and metabolic problems. The most important aspect of the surgical management of patients with acute intestinal failure associated with intra-abdominal infection is management of sepsis, since recovery is unlikely in the presence of active infection. Moreover, effective nutritional support and restoration of body composition is not possible if sepsis remains unresolved. Surgical strategies to deal with intra-abdominal infection may involve percutaneous drainage, laparotomy and resection of fistulating segments of intestine and, when infection is persistent and contamination extensive, laparostomy (a technique in which the abdomen is left open and allowed to heal by secondary intention). Surgical treatment should not only be timely and effective, but also aimed at preventing secondary damage to the small intestine, in order to minimise the risk of short bowel syndrome. In some cases a proximal defunctioning stoma may be required, with prolonged nutritional support, using either home total parenteral nutrition or feeding via the defunctioned distal gut (fistuloclysis), pending restoration of intestinal continuity. The role of surgical treatment for patients with short bowel syndrome is less clear. While surgery is frequently required for the management of complications of short bowel syndrome (including gallstones and possibly peptic ulcer disease), the role of intestinal lengthening and tapering procedures (to increase functional intestinal length), and artificial valves, reversed segments and colonic interposition (to reduce intestinal transit) remains controversial. For some patients with short bowel syndrome and, in particular, those with combined intestinal and hepatic failure, intestinal transplantation may become the treatment of choice as long-term results continue to improve.

Role of bacteria in the pathogenesis of short bowel syndrome-associated D-lactic acidemia

1997 ◽  
Vol 22 (5) ◽  
pp. 285-293 ◽  
Author(s):  
G.P..A Bongaerts ◽  
J.J.M. Tolboom ◽  
A.H.J. Naber ◽  
W.J.K. Sperl ◽  
R.S.V.M. Severijnen ◽  
...  
Keyword(s):  
Short Bowel Syndrome ◽  
Short Bowel ◽  
Lactic Acidemia

Role of the Colon in Short Bowel Syndrome and Intestinal Transplantation

2009 ◽  
Vol 48 (Suppl 2) ◽  
pp. S66-S71 ◽  
Author(s):  
Olivier Goulet ◽  
Virginie Colomb-Jung ◽  
Francisca Joly
Keyword(s):  
Short Bowel Syndrome ◽  
Intestinal Transplantation ◽  
Short Bowel

scholarly journals To Wean or Not to Wean: The Role of Autologous Reconstructive Surgery in the Natural History of Pediatric Short Bowel Syndrome on Behalf of Italian Society for Gastroenterology, Hepatology and Nutrition (SIGENP)

Nutrients ◽  
2020 ◽  
Vol 12 (7) ◽  
pp. 2136
Author(s):  
Teresa Capriati ◽  
Antonella Mosca ◽  
Tommaso Alterio ◽  
Maria Immacolata Spagnuolo ◽  
Paolo Gandullia ◽  
...  
Keyword(s):  
Short Bowel Syndrome ◽  
Reconstructive Surgery ◽  
Intestinal Adaptation ◽  
Primary Diagnosis ◽  
Primary Objective ◽  
Poor Growth ◽  
Short Bowel ◽  
History Of ◽  
Selection Of

Pediatric Short Bowel Syndrome (SBS) can require prolonged parenteral nutrition (PN). Over the years, SBS management has been implemented by autologous gastrointestinal reconstructive surgery (AGIR). The primary objective of the present review was to assess the effect of AGIR on weaning off PN. We also evaluated how AGIR impacts survival, the need for transplantation (Tx) and the development of liver disease (LD). We conducted a systematic literature search to identify studies published from January 1999 to the present and 947 patients were identified. PN alone was weakly associated with higher probability of weaning from PN (OR = 1.1, p = 0.03) and of surviving (OR = 1.05, p = 0.01). Adjusting for age, the probability of weaning off PN but of not surviving remained significantly associated with PN alone (OR = 1.08, p = 0.03). Finally, adjusting for age and primary diagnosis (gastroschisis), any association was lost. The prevalence of TX and LD did not differ by groups. In conclusion, in view of the low benefit in terms of intestinal adaptation and of the not negligible rate of complications (20%), a careful selection of candidates for AGIR should be required. Bowel dilation associated with failure of advancing EN and poor growth, should be criteria to refer for AGIR.

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