Cd5 Suppresses Il-15-Induced Proliferation of Human Memory Cd8+ T Cells by Inhibiting mTOR Pathways

2021 ◽  
Author(s):  
Young Joon Choi ◽  
Hoyoung Lee ◽  
Jong Hoon Kim ◽  
So-Young Kim ◽  
June-Young Koh ◽  
...  
Keyword(s):  
T Cells ◽  
Cd8 T Cells ◽  
Human Memory ◽  
Memory Cd8 T Cells

scholarly journals A Distinct Subset of Self-Renewing Human Memory CD8+ T Cells Survives Cytotoxic Chemotherapy

Immunity ◽  
2009 ◽  
Vol 31 (5) ◽  
pp. 834-844 ◽  
Author(s):  
Cameron J. Turtle ◽  
Hillary M. Swanson ◽  
Nobuharu Fujii ◽  
Elihu H. Estey ◽  
Stanley R. Riddell
Keyword(s):  
T Cells ◽  
Cd8 T Cells ◽  
Human Memory ◽  
Cytotoxic Chemotherapy ◽  
Memory Cd8 T Cells ◽  
Distinct Subset

scholarly journals Human memory CD8 T cell effector potential is epigenetically preserved during in vivo homeostasis

2017 ◽  
Vol 214 (6) ◽  
pp. 1593-1606 ◽  
Author(s):  
Hossam A. Abdelsamed ◽  
Ardiana Moustaki ◽  
Yiping Fan ◽  
Pranay Dogra ◽  
Hazem E. Ghoneim ◽  
...  
Keyword(s):  
T Cells ◽  
T Cell ◽  
Cd8 T Cells ◽  
Cd8 T Cell ◽  
Human Memory ◽  
Memory Cd8 T Cells ◽  
Memory Cd8 T Cell ◽  
Cell Effector

Antigen-independent homeostasis of memory CD8 T cells is vital for sustaining long-lived T cell–mediated immunity. In this study, we report that maintenance of human memory CD8 T cell effector potential during in vitro and in vivo homeostatic proliferation is coupled to preservation of acquired DNA methylation programs. Whole-genome bisulfite sequencing of primary human naive, short-lived effector memory (TEM), and longer-lived central memory (TCM) and stem cell memory (TSCM) CD8 T cells identified effector molecules with demethylated promoters and poised for expression. Effector-loci demethylation was heritably preserved during IL-7– and IL-15–mediated in vitro cell proliferation. Conversely, cytokine-driven proliferation of TCM and TSCM memory cells resulted in phenotypic conversion into TEM cells and was coupled to increased methylation of the CCR7 and Tcf7 loci. Furthermore, haploidentical donor memory CD8 T cells undergoing in vivo proliferation in lymphodepleted recipients also maintained their effector-associated demethylated status but acquired TEM-associated programs. These data demonstrate that effector-associated epigenetic programs are preserved during cytokine-driven subset interconversion of human memory CD8 T cells.

scholarly journals Granzyme B secretion by human memory CD4 T cells is less strictly regulated compared to memory CD8 T cells

2014 ◽  
Vol 15 (1) ◽  
Author(s):  
Lin Lin ◽  
Jacob Couturier ◽  
Xiaoying Yu ◽  
Miguel A Medina ◽  
Claudia A Kozinetz ◽  
...  
Keyword(s):  
T Cells ◽  
Cd8 T Cells ◽  
Cd4 T Cells ◽  
Granzyme B ◽  
Human Memory ◽  
Memory Cd8 T Cells ◽  
Memory Cd4 T Cells

scholarly journals Transcriptome Signatures Reveal Rapid Induction of Immune-Responsive Genes in Human Memory CD8+ T Cells

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Cheng Yang ◽  
Asma Khanniche ◽  
Joanna R. DiSpirito ◽  
Ping Ji ◽  
Shujun Wang ◽  
...  
Keyword(s):  
T Cells ◽  
Cd8 T Cells ◽  
Human Memory ◽  
Memory Cd8 T Cells ◽  
Rapid Induction

scholarly journals Delineation of antigen-specific and antigen-nonspecific CD8+ memory T-cell responses after cytokine-based cancer immunotherapy

Blood ◽  
2012 ◽  
Vol 119 (13) ◽  
pp. 3073-3083 ◽  
Author(s):  
Julia K. Tietze ◽  
Danice E. C. Wilkins ◽  
Gail D. Sckisel ◽  
Myriam N. Bouchlaka ◽  
Kory L. Alderson ◽  
...  
Keyword(s):  
T Cells ◽  
T Cell ◽  
Cd8 T Cells ◽  
Human Memory ◽  
Antigen Specificity ◽  
Antitumor Effects ◽  
Memory Cd8 T Cells ◽  
Specific Tumor

Abstract Memory T cells exhibit tremendous antigen specificity within the immune system and accumulate with age. Our studies reveal an antigen-independent expansion of memory, but not naive, CD8+ T cells after several immunotherapeutic regimens for cancer resulting in a distinctive phenotype. Signaling through T-cell receptors (TCRs) or CD3 in both mouse and human memory CD8+ T cells markedly up-regulated programmed death-1 (PD-1) and CD25 (IL-2 receptor α chain), and led to antigen-specific tumor cell killing. In contrast, exposure to cytokine alone in vitro or with immunotherapy in vivo did not up-regulate these markers but resulted in expanded memory CD8+ T cells expressing NKG2D, granzyme B, and possessing broadly lytic capabilities. Blockade of NKG2D in mice also resulted in significantly diminished antitumor effects after immunotherapy. Treatment of TCR-transgenic mice bearing nonantigen expressing tumors with immunotherapy still resulted in significant antitumor effects. Human melanoma tissue biopsies obtained from patients after topically applied immunodulatory treatment resulted in increased numbers of these CD8+ CD25− cells within the tumor site. These findings demonstrate that memory CD8+ T cells can express differential phenotypes indicative of adaptive or innate effectors based on the nature of the stimuli in a process conserved across species.

scholarly journals Synapse propensity of human memory CD8 T cells confers competitive advantage over naïve counterparts

2018 ◽  
Author(s):  
Viveka Mayya ◽  
Edward Judokusumo ◽  
Enas Abu-Shah ◽  
Willie Neiswanger ◽  
Lance C Kam ◽  
...  
Keyword(s):  
T Cells ◽  
Cd8 T Cells ◽  
Human Memory ◽  
Surface Expression ◽  
Memory Cells ◽  
Memory Cd8 T Cells ◽  
Immunological Synapses ◽  
Functional Features ◽  
Original Antigenic Sin ◽  
Antigen Presenting

AbstractMemory T cells are endowed with multiple functional features that enable them to be more protective than naïve T cells against infectious threats. It is not known if memory cells have a higher synapse propensity, i.e. increased probability to form immature immunological synapses that then provide an entry into different modes of durable interaction with antigen presenting cells. Here we show that only human memory CD8 T cells have remarkably high synapse propensity compared to naïve counterparts. Such a dichotomy between naïve and memory cells is not observed within the human CD4 or murine CD8 T cell population. Increased surface expression of LFA1 contributes to the higher synapse propensity in human memory CD8 T cells. Finally, we show that higher synapse propensity in human memory CD8 T cells allows them to compete out naïve CD8 T cells from getting recruited to the response. This observation has implications for original antigenic sin and aging of the immune system in humans.

scholarly journals Origin and differentiation of human memory CD8 T cells after vaccination

Nature ◽  
2017 ◽  
Vol 552 (7685) ◽  
pp. 362-367 ◽  
Author(s):  
Rama S. Akondy ◽  
Mark Fitch ◽  
Srilatha Edupuganti ◽  
Shu Yang ◽  
Haydn T. Kissick ◽  
...  
Keyword(s):  
T Cells ◽  
Cd8 T Cells ◽  
Human Memory ◽  
Memory Cd8 T Cells

scholarly journals Cutting Edge: Synapse Propensity of Human Memory CD8 T Cells Confers Competitive Advantage over Naive Counterparts

2019 ◽  
Vol 203 (3) ◽  
pp. 601-606 ◽  
Author(s):  
Viveka Mayya ◽  
Edward Judokusumo ◽  
Enas Abu-Shah ◽  
Willie Neiswanger ◽  
Chirag Sachar ◽  
...  
Keyword(s):  
T Cells ◽  
Competitive Advantage ◽  
Cd8 T Cells ◽  
Human Memory ◽  
Cutting Edge ◽  
Memory Cd8 T Cells
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