scholarly journals mTOR signaling promotes a robust and continuous production of IFN-γ by human memory CD8+T cells and their proliferation

2015 ◽  
Vol 45 (3) ◽  
pp. 893-902 ◽  
Author(s):  
Ruka Setoguchi ◽  
Yui Matsui ◽  
Kousuke Mouri
Keyword(s):  
T Cells ◽  
Cd8 T Cells ◽  
Continuous Production ◽  
Human Memory ◽  
Mtor Signaling ◽  
Memory Cd8 T Cells ◽  
Ifn Γ

Cd5 Suppresses Il-15-Induced Proliferation of Human Memory Cd8+ T Cells by Inhibiting mTOR Pathways

2021 ◽  
Author(s):  
Young Joon Choi ◽  
Hoyoung Lee ◽  
Jong Hoon Kim ◽  
So-Young Kim ◽  
June-Young Koh ◽  
...  
Keyword(s):  
T Cells ◽  
Cd8 T Cells ◽  
Human Memory ◽  
Memory Cd8 T Cells

scholarly journals A Distinct Subset of Self-Renewing Human Memory CD8+ T Cells Survives Cytotoxic Chemotherapy

Immunity ◽  
2009 ◽  
Vol 31 (5) ◽  
pp. 834-844 ◽  
Author(s):  
Cameron J. Turtle ◽  
Hillary M. Swanson ◽  
Nobuharu Fujii ◽  
Elihu H. Estey ◽  
Stanley R. Riddell
Keyword(s):  
T Cells ◽  
Cd8 T Cells ◽  
Human Memory ◽  
Cytotoxic Chemotherapy ◽  
Memory Cd8 T Cells ◽  
Distinct Subset

scholarly journals Human memory CD8 T cell effector potential is epigenetically preserved during in vivo homeostasis

2017 ◽  
Vol 214 (6) ◽  
pp. 1593-1606 ◽  
Author(s):  
Hossam A. Abdelsamed ◽  
Ardiana Moustaki ◽  
Yiping Fan ◽  
Pranay Dogra ◽  
Hazem E. Ghoneim ◽  
...  
Keyword(s):  
T Cells ◽  
T Cell ◽  
Cd8 T Cells ◽  
Cd8 T Cell ◽  
Human Memory ◽  
Memory Cd8 T Cells ◽  
Memory Cd8 T Cell ◽  
Cell Effector

Antigen-independent homeostasis of memory CD8 T cells is vital for sustaining long-lived T cell–mediated immunity. In this study, we report that maintenance of human memory CD8 T cell effector potential during in vitro and in vivo homeostatic proliferation is coupled to preservation of acquired DNA methylation programs. Whole-genome bisulfite sequencing of primary human naive, short-lived effector memory (TEM), and longer-lived central memory (TCM) and stem cell memory (TSCM) CD8 T cells identified effector molecules with demethylated promoters and poised for expression. Effector-loci demethylation was heritably preserved during IL-7– and IL-15–mediated in vitro cell proliferation. Conversely, cytokine-driven proliferation of TCM and TSCM memory cells resulted in phenotypic conversion into TEM cells and was coupled to increased methylation of the CCR7 and Tcf7 loci. Furthermore, haploidentical donor memory CD8 T cells undergoing in vivo proliferation in lymphodepleted recipients also maintained their effector-associated demethylated status but acquired TEM-associated programs. These data demonstrate that effector-associated epigenetic programs are preserved during cytokine-driven subset interconversion of human memory CD8 T cells.

scholarly journals Memory CD8 + T Cells Can Outsource IFN-γ Production but Not Cytolytic Killing for Antiviral Protection

2013 ◽  
Vol 13 (5) ◽  
pp. 546-557 ◽  
Author(s):  
Sanda Remakus ◽  
Daniel Rubio ◽  
Avital Lev ◽  
Xueying Ma ◽  
Min Fang ◽  
...  
Keyword(s):  
T Cells ◽  
Cd8 T Cells ◽  
Memory Cd8 T Cells ◽  
Ifn Γ

scholarly journals Rapid Effector Function in CD8+ Memory T Cells

1997 ◽  
Vol 186 (6) ◽  
pp. 859-865 ◽  
Author(s):  
Ajit Lalvani ◽  
Roger Brookes ◽  
Sophie Hambleton ◽  
Warwick J. Britton ◽  
Adrian V.S. Hill ◽  
...  
Keyword(s):  
T Cells ◽  
Influenza Virus ◽  
Cd8 T Cells ◽  
Ex Vivo ◽  
Influenza Virus Infection ◽  
Immunological Memory ◽  
Effector Function ◽  
Memory State ◽  
Memory Cd8 T Cells ◽  
Ifn Γ

The nature of the CD8+ T cells that underlie antiviral protective immunological memory in vivo is unclear. We have characterized peptide-specific CD8+ T lymphocytes directly ex vivo from peripheral blood in humans with past exposure to influenza virus, using single cell interferon γ (IFN-γ) release as a measure of effector function. In individuals in the memory state with respect to influenza virus infection, unrestimulated antigen-specific CD8+ T cells displayed IFN-γ release within 6 h of antigen contact, identifying a population of memory CD8+ T cells that exhibit effector function without needing to divide and differentiate over several days. We have quantified circulating CD8+ effector T cells specific for six different MHC class I–restricted influenza virus epitopes. Enumeration of these CD8+ T cells gives frequencies of peptide-specific T cells that correlate with, but are in general severalfold higher than, CTL precursor frequencies derived from limiting dilution analysis, indicating that this novel population of memory CD8+ T cells has hitherto been undetected by standard means. The phenotype of these cells, which persist at a low frequency long after recovery from an acute viral infection, suggests that they play a role in protective immunological memory.

scholarly journals Granzyme B secretion by human memory CD4 T cells is less strictly regulated compared to memory CD8 T cells

2014 ◽  
Vol 15 (1) ◽  
Author(s):  
Lin Lin ◽  
Jacob Couturier ◽  
Xiaoying Yu ◽  
Miguel A Medina ◽  
Claudia A Kozinetz ◽  
...  
Keyword(s):  
T Cells ◽  
Cd8 T Cells ◽  
Cd4 T Cells ◽  
Granzyme B ◽  
Human Memory ◽  
Memory Cd8 T Cells ◽  
Memory Cd4 T Cells

scholarly journals Transcriptome Signatures Reveal Rapid Induction of Immune-Responsive Genes in Human Memory CD8+ T Cells

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Cheng Yang ◽  
Asma Khanniche ◽  
Joanna R. DiSpirito ◽  
Ping Ji ◽  
Shujun Wang ◽  
...  
Keyword(s):  
T Cells ◽  
Cd8 T Cells ◽  
Human Memory ◽  
Memory Cd8 T Cells ◽  
Rapid Induction

scholarly journals Memory CD8+ T Cells Provide Innate Immune Protection against Listeria monocytogenes in the Absence of Cognate Antigen

2003 ◽  
Vol 198 (10) ◽  
pp. 1583-1593 ◽  
Author(s):  
Rance E. Berg ◽  
Emily Crossley ◽  
Sean Murray ◽  
James Forman
Keyword(s):  
Immune Response ◽  
T Cells ◽  
Listeria Monocytogenes ◽  
Innate Immune Response ◽  
Cd8 T Cells ◽  
Primary Source ◽  
Innate Immune ◽  
Memory Cd8 T Cells ◽  
Cognate Antigen ◽  
Ifn Γ

Interferon (IFN)-γ plays an important role in the innate immune response against intracellular bacterial pathogens. It is commonly thought that natural killer cells are the primary source of this cytokine that is involved in activating antibacterial effects in infected cells and polarizing CD4+ T cells toward the Th1 subset. However, here we show that both effector and memory CD8+ T cells have the potential to secrete IFN-γ in response to interleukin (IL)-12 and IL-18 in the absence of cognate antigen. We demonstrate that memory CD8+ T cells specific for the ovalbumin protein secrete IFN-γ rapidly after infection with wild-type Listeria monocytogenes (LM). Furthermore, small numbers of ovalbumin-specific, memory CD8+ T cells can reduce spleen and liver bacterial counts in IFN-γ–deficient mice 3 d after LM infection. Up-regulation of the receptors for IL-12 and IL-18 provides a mechanism for the ability of memory CD8+ T cells to respond in this antigen nonspecific manner. Thus, CD8+ T cells play an important role in the innate immune response against intracellular pathogens by rapidly secreting IFN-γ in response to IL-12 and IL-18.

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